The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Human Neural Stem Cell Transplantation Promotes Functional Recovery in Rats With Experimental Intracerebral Hemorrhage
Abstract
Background and Purpose— Cell transplantation has been used to reduce behavioral deficit in cerebral ischemia. However, there is no report about cell transplantation in experimental intracerebral hemorrhage (ICH). We hypothesize that intravenously transplanted human neural stem cells (NSCs) can migrate and differentiate into neurons or glial cells, thereby improving functional outcome in ICH. Methods— Experimental ICH was induced by intrastriatal administration of bacterial collagenase in adult rats. One day after surgery, the rats were randomly divided into 2 groups to receive intravenously either immortalized Lac z –positive human NSCs (5×10 6 cells in 500 μL, n=12) or the same amount of saline (n=13). The animals were evaluated for 8 weeks with modified limb placing and rotarod tests. Transplanted NSCs were detected by X-gal histochemistry or β-gal immunohistochemistry with double labeling of GFAP, NeuN, neurofilament, or CNPase. Results— Intravenously transplanted NSCs migrated selectively to the perihematomal areas and differentiated into neurons (≈10% of β-gal + cells) and astrocytes (≈75%). The NSC-transplanted group showed better functional performance on rotarod test after 2 weeks and on modified limb placing test after 5 weeks compared with the control group ( P <0.05), and these effects persisted for up to 8 weeks. There was no difference in the final hemispheric area between the 2 groups. Conclusions— Intravenously transplanted NSCs can enter the rat brain with ICH, survive, migrate, and improve functional recovery. Transplantation of human NSCs can be used to restore neurological deficits in experimental ICH.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Chen, J., Li, Y., Wang, L., Zhang, Z., Lu, D., Lu, M., & Chopp, M. (2001) · Stroke · doi:10.1161/01.str.32.4.1005 · Cited by 1,764
Spontaneous intracerebral hemorrhage
Qureshi, A. I., Tuhrim, S., Broderick, J. P., Batjer, H. H., Hondo, H., & Hanley, D. F. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105103441907 · Cited by 1,719
Chen, J., Sanberg, P. R., Li, Y., Wang, L., Lu, M., Willing, A. E., Sanchez-Ramos, J., & Chopp, M. (2001) · Stroke · doi:10.1161/hs1101.098367 · Cited by 1,345
Cell replacement therapies for central nervous system disorders
Björklund, A., & Lindvall, O. (2000) · Nature Neuroscience · doi:10.1038/75705 · Cited by 934
Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery
Li, Y., Chen, J., Chen, X. G., Wang, L., Gautam, S. C., Xu, Y. X., Katakowski, M., Zhang, L. J., Lu, M., Janakiraman, N., et al. (2002) · Neurology · doi:10.1212/wnl.59.4.514 · Cited by 869
Zhao, L.-R., Duan, W.-M., Reyes, M., Keene, C. D., Verfaillie, C. M., & Low, W. C. (2002) · Experimental Neurology · doi:10.1006/exnr.2001.7853 · Cited by 823
Flax, J. D., Aurora, S., Yang, C., Simonin, C., Wills, A. M., Billinghurst, L. L., Jendoubi, M., Sidman, R. L., Wolfe, J. H., Kim, S. U., et al. (1998) · Nature Biotechnology · doi:10.1038/3473 · Cited by 770
Self-citationTransplantation of cultured human neuronal cells for patients with stroke
Kondziolka, D., Wechsler, L., Goldstein, S., Meltzer, C., Thulborn, K. R., Gebel, J., Jannetta, P., DeCesare, S., Elder, E. M., McGrogan, M., et al. (2000) · Neurology · doi:10.1212/wnl.55.4.565 · Cited by 629
Ogawa, Y., Sawamoto, K., Miyata, T., Miyao, S., Watanabe, M., Nakamura, M., Bregman, B. S., Koike, M., Uchiyama, Y., Toyama, Y., et al. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10341 · Cited by 544
Chen, J., Li, Y., Wang, L., Lu, M., Zhang, X., & Chopp, M. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(01)00557-3 · Cited by 527
Cited by
The therapeutic potential of neural stem cells
Martino, G., & Pluchino, S. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1908 · Cited by 744
Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation
Zhou, Y., Wang, Y., Wang, J., Anne Stetler, R., & Yang, Q.-W. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.003 · Cited by 628
Kelly, S., Bliss, T. M., Shah, A. K., Sun, G. H., Ma, M., Foo, W. C., Masel, J., Yenari, M. A., Weissman, I. L., Uchida, N., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404474101 · Cited by 614
Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke
Lee, S.-T., Chu, K., Jung, K.-H., Kim, S.-J., Kim, D.-H., Kang, K.-M., Hong, N. H., Kim, J.-H., Ban, J.-J., Park, H.-K., et al. (2008) · Brain · doi:10.1093/brain/awm306 · Cited by 424
Self-citationCell transplantation therapy for stroke
Bliss, T., Guzman, R., Daadi, M., & Steinberg, G. K. (2007) · Stroke · doi:10.1161/01.str.0000247888.25985.62 · Cited by 374
Metadata
- Authors
- Jeong, S.-W., Chu, K., Jung, K.-H., Kim, S. U., Kim, M., & Roh, J.-K.
- Venue
- Stroke
- Published
- 2003-09
- Volume
- 34
- Issue
- 9
- Pages
- 2258-2263
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2101873759
- Cited by
- 366
- References
- 26
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Human Neural Stem Cell Transplantation Promotes Functional Recovery in Rats With Experimental Intracerebral Hemorrhage. https://app.cochat.ai/papers/10.1161/01.str.0000083698.20199.1f
- The paper
- Jeong, S.-W., Chu, K., Jung, K.-H., Kim, S. U., Kim, M., & Roh, J.-K. (2003). Human Neural Stem Cell Transplantation Promotes Functional Recovery in Rats With Experimental Intracerebral Hemorrhage. Stroke. https://doi.org/10.1161/01.str.0000083698.20199.1f
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
