The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Transplantation of cultured human neuronal cells for patients with stroke
Abstract
Transplantation of cultured neuronal cells is safe in animal models and improves motor and cognitive deficits in rats with stroke. The authors studied the safety and feasibility of human neuronal cellular transplantation in patients with basal ganglia stroke and fixed motor deficits, including 12 patients (aged 44 to 75 years) with an infarct 6 months to 6 years previously (stable for at least 2 months). Serial evaluations (12 to 18 months) showed no adverse cell-related serologic or imaging-defined effects. The total European Stroke Scale score improved in six patients (3 to 10 points), with a mean improvement 2.9 points in all patients (p = 0. 046). Six of 11 PET scans at 6 months showed improved fluorodeoxyglucose uptake at the implant site. Neuronal transplantation is feasible in patients with motor infarction.
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Cites
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033
Cited by
Stem cell therapy for human neurodegenerative disorders–how to make it work
Lindvall, O., Kokaia, Z., & Martinez-Serrano, A. (2004) · Nature Medicine · doi:10.1038/nm1064 · Cited by 915
Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic
Zhang, Z. G., & Chopp, M. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70061-4 · Cited by 596
Neurotransplantation for patients with subcortical motor stroke: a Phase 2 randomized trial
Kondziolka, D., Steinberg, G. K., Wechsler, L., Meltzer, C. C., Elder, E., Gebel, J., DeCesare, S., Jovin, T., Zafonte, R., Lebowitz, J., et al. (2005) · Journal of Neurosurgery · doi:10.3171/jns.2005.103.1.0038 · Cited by 451
Self-citationCell transplantation therapy for stroke
Bliss, T., Guzman, R., Daadi, M., & Steinberg, G. K. (2007) · Stroke · doi:10.1161/01.str.0000247888.25985.62 · Cited by 374
Neural stem/precursor cells for the treatment of ischemic stroke
Bacigaluppi, M., Pluchino, S., Martino, G., Kilic, E., & Hermann, D. M. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.06.012 · Cited by 111
Metadata
- Authors
- Kondziolka, D., Wechsler, L., Goldstein, S., Meltzer, C., Thulborn, K. R., Gebel, J., Jannetta, P., DeCesare, S., Elder, E. M., McGrogan, M., Reitman, M. A., & Bynum, L.
- Venue
- Neurology
- Published
- 2000-08-22
- Volume
- 55
- Issue
- 4
- Pages
- 565-569
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2167705610
- Cited by
- 629
- References
- 1
- FWCI
- 35.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Transplantation of cultured human neuronal cells for patients with stroke. https://app.cochat.ai/papers/10.1212/wnl.55.4.565
- The paper
- Kondziolka, D., Wechsler, L., Goldstein, S., Meltzer, C., Thulborn, K. R., Gebel, J., Jannetta, P., DeCesare, S., Elder, E. M., McGrogan, M., Reitman, M. A., & Bynum, L. (2000). Transplantation of cultured human neuronal cells for patients with stroke. Neurology. https://doi.org/10.1212/wnl.55.4.565
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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