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Cited by 157Lipoproteins and Cardiovascular HealthAcute Ischemic Stroke ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.

Cholesterol and the Risk of Ischemic Stroke

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Bowman, Thomas S., Sesso, Howard D., Ma, Jing, Kurth, Tobias, Kase, Carlos S., Stampfer, Meir J., Gaziano, J. Michael·2003·Stroke
DOI 10.1161/01.str.0000102171.91292.dc
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Abstract

Background and Purpose— Large epidemiological studies have not established cholesterol levels as a risk factor for ischemic stroke, but recent clinical trials have demonstrated a reduction in the ischemic stroke rate for patients taking HMG-CoA reductase inhibitors (“statins”). The goal of this study was to evaluate whether total cholesterol (TC), high-density lipoprotein (HDL), triglycerides, and the TC:HDL ratio are risk factors for ischemic stroke in apparently healthy men enrolled in the Physicians’ Health Study. Methods— We used a nested case-control study design and matched 296 ischemic stroke cases with an equal number of controls on age, tobacco use, and follow-up time. At baseline, TC, HDL, and triglyceride levels were measured. We calculated odds ratios (ORs) and their 95% confidence intervals (CIs) using conditional logistic regression, adjusting for major risk factors for ischemic stroke. Results— Compared with the reference lowest quartile, the highest quartile for TC had an adjusted OR of 1.56 (95% CI, 0.84 to 2.92), the highest quartile of HDL had an adjusted OR of 0.75 (95% CI, 0.43 to 1.30), and the highest quartile of triglycerides had an adjusted OR of 1.07 (95% CI, 0.63 to 1.82). Although the highest quartile of the TC:HDL ratio had an adjusted OR of 1.62 (95% CI, 0.93 to 2.82), the risk of ischemic stroke was not a linear relationship. Conclusions— After adjustment, TC, HDL, and triglycerides were not significantly associated with ischemic stroke risk, and for the TC:HDL ratio, a suggestion of increased risk of ischemic stroke was limited to those with the highest levels.

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Research works printed but not linked: 8

  1. 10.1161/str.32.1.280 · DOI
  2. NCEP. Summary of third report of NCEP Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults III. JAMA. 2001: 2486–2497.
  3. 10.1161/str.27.2.238 · DOI
  4. 10.1161/str.30.12.2535 · DOI
  5. 10.1161/str.31.8.1893 · DOI
  6. 10.1161/str.31.8.1882 · DOI
  7. 10.1161/circ.103.3.348 · DOI
  8. 10.1161/circ.103.23.2828 · DOI

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Metadata

Authors
Bowman, T. S., Sesso, H. D., Ma, J., Kurth, T., Kase, C. S., Stampfer, M. J., & Gaziano, J. M.
Affiliations
Boston University (US)
ORCID
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-12
Volume
34
Issue
12
Pages
2930-2934
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/01.str.0000102171.91292.dc
OpenAlex
W2080056609
Cited by
157
References
45
Citations by year
2026: 2 · 2025: 2 · 2024: 4 · 2023: 8 · 2022: 10 · 2021: 7 · 2020: 5 · 2019: 9 · 2018: 10 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 7
FWCI
7.67
Type
journal article
Language
en
Open access
Locations
  • Stroke (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
  • National Institutes of Health (CA 34944, HL-26490)
  • National Heart, Lung, and Blood Institute (HL-34595, HL 26490, R01HL034595)
  • National Cancer Institute (R01CA040360, CA 34944, R01CA097193, CA 40360)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
ischemic stroke, total cholesterol, high-density lipoprotein, triglycerides, TC/HDL-C ratio, stroke risk factors, statins, Physicians' Health Study, healthy men
MeSH terms
Brain Ischemia, Cholesterol, Humans, Lipoproteins, HDL, Male, Middle Aged, Prospective Studies, Risk, Risk Factors, Triglycerides, United States, Comorbidity, Logistic Models, Odds Ratio, Case-Control Studies, Randomized Controlled Trials as Topic, Stroke

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