Cited by 107Iron Metabolism and DisordersAcute Ischemic Stroke ManagementNeurological diseases and metabolism

Serum Ferritin Is a Risk Factor for Stroke in Postmenopausal Women

Open access
van der, Daphne L., Grobbee, Diederick E., Roest, Mark, Marx, Joannes J.M., Voorbij, Hieronymus A., van der Schouw, Yvonne T.·2005·Stroke

Abstract

Background and Purpose— Iron is an essential element for the human body. It has, however, been suggested that excessive iron stores may increase the risk of vascular disease. So far, epidemiologic studies on stroke are sparse. Methods— We studied the association between iron status and stroke risk in a population-based cohort of 11 471 Dutch postmenopausal women between 49 and 70 years of age. Women were included between 1993 and 1997 and followed up until January 1, 2000, for cerebrovascular events. We conducted a case-cohort study by using all stroke cases (n=63) and a random sample of the baseline cohort (n=1134). Serum ferritin, serum iron, and transferrin saturation were measured as markers of iron status. A weighted Cox proportional-hazards model was used to estimate crude and multivariate-adjusted hazard ratios for tertiles of different iron parameters in relation to stroke. Results— In a multivariate model, the highest tertile of serum ferritin concentration was associated with an increased risk of stroke (hazard ratio [HR], 1.45; 95% confidence interval [CI], 0.87 to 2.42) compared with the lowest tertile. For ischemic stroke, the increase was more pronounced (HR, 2.23; 95% CI, 1.05 to 4.73) and reached statistical significance. Conclusions— Neither serum iron nor transferrin saturation was associated with an increased stroke risk. However, higher serum ferritin concentrations in postmenopausal women are associated with an increased risk of ischemic stroke.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1161/01.str.0000173172.82880.72

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
van der, D. L., Grobbee, D. E., Roest, M., Marx, J. J. M., Voorbij, H. A., & van der Schouw, Y. T.
Affiliations
  • From the Julius Center for Health Sciences and Primary Care (D.L.v.d.A, D.E.G, Y.T.v.d.S), the Research Laboratory of the Department of Clinical Chemistry (M.R, H.A.V), and the Eijkman Winkler Institute for Microbiology, Infectious Diseases and Inflammation (J.J.M.M), University Medical Center Utrecht, The Netherlands.
  • University Medical Center Utrecht (NL)
Venue
Stroke
Published
2005-08
Volume
36
Issue
8
Pages
1637-1641
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
OpenAlex
W2133807501
Cited by
107
References
25
Citations by year
2025: 7 · 2024: 7 · 2023: 5 · 2022: 12 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 3
FWCI
3.12
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Stroke (publishedVersion)
  • PubMed (publishedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
Funders
European Commission
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords
serum ferritin, stroke risk, ischemic stroke, postmenopausal women, iron status, serum iron, transferrin saturation, iron overload, cerebrovascular disease
MeSH terms
Aged, Brain Ischemia, Female, Ferritins, Humans, Hypertension, Iron, Middle Aged, Risk, Risk Factors, Smoking, Transferrin, Cohort Studies, Body Mass Index, Multivariate Analysis, Proportional Hazards Models, Postmenopause, Oxidative Stress, Stroke

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review