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Cited by 107Iron Metabolism and DisordersAcute Ischemic Stroke ManagementNeurological diseases and metabolism

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Serum Ferritin Is a Risk Factor for Stroke in Postmenopausal Women

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van der, Daphne L., Grobbee, Diederick E., Roest, Mark, Marx, Joannes J.M., Voorbij, Hieronymus A., van der Schouw, Yvonne T.·2005·Stroke
DOI 10.1161/01.str.0000173172.82880.72
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Abstract

Background and Purpose— Iron is an essential element for the human body. It has, however, been suggested that excessive iron stores may increase the risk of vascular disease. So far, epidemiologic studies on stroke are sparse. Methods— We studied the association between iron status and stroke risk in a population-based cohort of 11 471 Dutch postmenopausal women between 49 and 70 years of age. Women were included between 1993 and 1997 and followed up until January 1, 2000, for cerebrovascular events. We conducted a case-cohort study by using all stroke cases (n=63) and a random sample of the baseline cohort (n=1134). Serum ferritin, serum iron, and transferrin saturation were measured as markers of iron status. A weighted Cox proportional-hazards model was used to estimate crude and multivariate-adjusted hazard ratios for tertiles of different iron parameters in relation to stroke. Results— In a multivariate model, the highest tertile of serum ferritin concentration was associated with an increased risk of stroke (hazard ratio [HR], 1.45; 95% confidence interval [CI], 0.87 to 2.42) compared with the lowest tertile. For ischemic stroke, the increase was more pronounced (HR, 2.23; 95% CI, 1.05 to 4.73) and reached statistical significance. Conclusions— Neither serum iron nor transferrin saturation was associated with an increased stroke risk. However, higher serum ferritin concentrations in postmenopausal women are associated with an increased risk of ischemic stroke.

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  1. 10.1161/circ.99.24.3118 · DOI
  2. 10.1161/str.25.8.8042204 · DOI
  3. 10.1161/circ.100.12.1268 · DOI
  4. 10.1161/circ.96.10.3300 · DOI
  5. 10.1161/res.87.10.840 · DOI
  6. 10.1161/str.29.1.258 · DOI

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Metadata

Authors
van der, D. L., Grobbee, D. E., Roest, M., Marx, J. J. M., Voorbij, H. A., & van der Schouw, Y. T.
Affiliations
  • From the Julius Center for Health Sciences and Primary Care (D.L.v.d.A, D.E.G, Y.T.v.d.S), the Research Laboratory of the Department of Clinical Chemistry (M.R, H.A.V), and the Eijkman Winkler Institute for Microbiology, Infectious Diseases and Inflammation (J.J.M.M), University Medical Center Utrecht, The Netherlands.
  • University Medical Center Utrecht (NL)
ORCID
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2005-08
Volume
36
Issue
8
Pages
1637-1641
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/01.str.0000173172.82880.72
OpenAlex
W2133807501
Cited by
107
References
25
Citations by year
2025: 7 · 2024: 7 · 2023: 5 · 2022: 12 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 3
FWCI
3.12
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Stroke (publishedVersion)
  • PubMed (publishedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
Funders
European Commission
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords
serum ferritin, stroke risk, ischemic stroke, postmenopausal women, iron status, serum iron, transferrin saturation, iron overload, cerebrovascular disease
MeSH terms
Aged, Brain Ischemia, Female, Ferritins, Humans, Hypertension, Iron, Middle Aged, Risk, Risk Factors, Smoking, Transferrin, Cohort Studies, Body Mass Index, Multivariate Analysis, Proportional Hazards Models, Postmenopause, Oxidative Stress, Stroke

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