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Serum Ferritin Is a Risk Factor for Stroke in Postmenopausal Women
Open accessAbstract
Background and Purpose— Iron is an essential element for the human body. It has, however, been suggested that excessive iron stores may increase the risk of vascular disease. So far, epidemiologic studies on stroke are sparse. Methods— We studied the association between iron status and stroke risk in a population-based cohort of 11 471 Dutch postmenopausal women between 49 and 70 years of age. Women were included between 1993 and 1997 and followed up until January 1, 2000, for cerebrovascular events. We conducted a case-cohort study by using all stroke cases (n=63) and a random sample of the baseline cohort (n=1134). Serum ferritin, serum iron, and transferrin saturation were measured as markers of iron status. A weighted Cox proportional-hazards model was used to estimate crude and multivariate-adjusted hazard ratios for tertiles of different iron parameters in relation to stroke. Results— In a multivariate model, the highest tertile of serum ferritin concentration was associated with an increased risk of stroke (hazard ratio [HR], 1.45; 95% confidence interval [CI], 0.87 to 2.42) compared with the lowest tertile. For ischemic stroke, the increase was more pronounced (HR, 2.23; 95% CI, 1.05 to 4.73) and reached statistical significance. Conclusions— Neither serum iron nor transferrin saturation was associated with an increased stroke risk. However, higher serum ferritin concentrations in postmenopausal women are associated with an increased risk of ischemic stroke.
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“another prediction is that iron excess should also aggravate the sequelae of stroke, and that appropriate chelation or free radical trapping agents should mitigate these effects. These predictions are indeed borne out [138,905-914].”
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Metadata
- Authors
- van der, D. L., Grobbee, D. E., Roest, M., Marx, J. J. M., Voorbij, H. A., & van der Schouw, Y. T.
- Affiliations
- From the Julius Center for Health Sciences and Primary Care (D.L.v.d.A, D.E.G, Y.T.v.d.S), the Research Laboratory of the Department of Clinical Chemistry (M.R, H.A.V), and the Eijkman Winkler Institute for Microbiology, Infectious Diseases and Inflammation (J.J.M.M), University Medical Center Utrecht, The Netherlands.
- University Medical Center Utrecht (NL)
- Venue
- Stroke
- Published
- 2005-08
- Volume
- 36
- Issue
- 8
- Pages
- 1637-1641
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2133807501
- Cited by
- 107
- References
- 25
- Citations by year
- 2025: 7 · 2024: 7 · 2023: 5 · 2022: 12 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Licence
- other-oa
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Funders
- European Commission
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- serum ferritin, stroke risk, ischemic stroke, postmenopausal women, iron status, serum iron, transferrin saturation, iron overload, cerebrovascular disease
- MeSH terms
- Aged, Brain Ischemia, Female, Ferritins, Humans, Hypertension, Iron, Middle Aged, Risk, Risk Factors, Smoking, Transferrin, Cohort Studies, Body Mass Index, Multivariate Analysis, Proportional Hazards Models, Postmenopause, Oxidative Stress, Stroke
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