The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors.
Abstract
We studied 52 asymptomatic subjects using magnetic resonance imaging, and we compared age-matched groups (51-70 years old) with and without white matter lesions with respect to carotid ultrasonography, cerebral blood flow (xenon-133 injection), and cerebrovascular risk factors. In the group with white matter signal abnormalities, we noted a higher frequency of extracranial carotid artery disease, a lower mean gray matter blood flow (F1), and a significant reduction (p less than 0.05) in blood flow of the slow-flowing (F2) compartment. Hypertension, diabetes mellitus, and cardiac diseases (p less than 0.002) were found more often in this group. Our results indicate that a higher incidence of changes known to be associated with an increased risk for stroke exists in the presence of white matter lesions in normal elderly individuals.
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Cites
MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging
Fazekas, F., Chawluk, J., Alavi, A., Hurtig, H., & Zimmerman, R. (1987) · American Journal of Roentgenology · doi:10.2214/ajr.149.2.351 · Cited by 5,334
Self-citationRegional Cerebral Blood Flow Estimated by 133 Xenon Inhalation
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Awad, I. A., Spetzler, R. F., Hodak, J. A., Awad, C. A., & Carey, R. (1986) · Stroke · doi:10.1161/01.str.17.6.1084 · Cited by 587
Periventricular hyperintensity as seen by magnetic resonance: prevalence and significance
Zimmerman, R., Fleming, C., Lee, B., Saint-Louis, L., & Deck, M. (1986) · American Journal of Roentgenology · doi:10.2214/ajr.146.3.443 · Cited by 286
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MR imaging of the aging brain: patchy white-matter lesions and dementia.
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Patchy, periventricular white matter lesions in the elderly : common observation during NMR imaging
Bradley, W. J. (1984) · Medical Entomology and Zoology · Cited by 186
Lechner, H., Schmidt, R., Bertha, G., Justich, E., Offenbacher, H., & Schneider, G. (1988) · Stroke · doi:10.1161/01.str.19.2.263 · Cited by 176
Self-citationSze, G. K., Armond, S. J. D., Brant-Zawadzki, M. N., Davis, R., Norman, D. M., & Newton, T. H. (1986) · American Journal of Roentgenology · doi:10.2214/ajr.147.2.331 · Cited by 157
Progressive cerebral ischemia antedates cerebrovascular symptoms by two years
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Cited by
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652
'Vascular Depression' Hypothesis
Alexopoulos, G. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830220033006 · Cited by 1,843
Pathogenesis of Leukoaraiosis: A Review
Pantoni, L., & Garcia, J. H. (1997) · Stroke · doi:10.1161/01.str.28.3.652 · Cited by 1,225
Pantoni, L., & Garcia, J. H. (1995) · Stroke · doi:10.1161/01.str.26.7.1293 · Cited by 538
White matter hyperintensities in late life depression: a systematic review
Herrmann, L. L., Le Masurier, M., & Ebmeier, K. P. (2007) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.124651 · Cited by 456
Metadata
- Authors
- Fazekas, F., Niederkorn, K., Schmidt, R., Offenbacher, H., Horner, S., Bertha, G., & Lechner, H.
- Venue
- Stroke
- Published
- 1988-10
- Volume
- 19
- Issue
- 10
- Pages
- 1285-1288
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2073094519
- Cited by
- 455
- References
- 11
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors. https://app.cochat.ai/papers/10.1161/01.str.19.10.1285
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- Fazekas, F., Niederkorn, K., Schmidt, R., Offenbacher, H., Horner, S., Bertha, G., & Lechner, H. (1988). White matter signal abnormalities in normal individuals: correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors. Stroke. https://doi.org/10.1161/01.str.19.10.1285
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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