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Regional Cerebral Blood Flow Estimated by 133 Xenon Inhalation

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OBRIST, WALTER D., THOMPSON, HOWARD K., WANG, HSIOH SHAN, WILKINSON, WILLIAM E.·1975·Stroke

Abstract

A method is described for estimating the clearance rate and fractional blood flow of the fast (gray matter) compartment of the brain from the first ten minutes of 133 Xe clearance curves, following a one-minute inhalation. Computer-simulated data were used to test the adequacy of the two-compartmental model employed, and to evaluate the stability of the parameters in the presence of random noise. A comparison was made between this approach and the previously reported three-compartmental analysis. Regional cerebral blood flow data were obtained on 48 young control subjects and 20 elderly demented patients. Hemispheral regional, and test-retest variations were determined, as well as differences between the groups.

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Metadata

Authors
OBRIST, W. D., THOMPSON, H. K., WANG, H. S., & WILKINSON, W. E.
Venue
Stroke
Published
1975-05
Volume
6
Issue
3
Pages
245-256
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
OpenAlex
W2027217568
Cited by
859
References
0
FWCI
22.13
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Regional Cerebral Blood Flow Estimated by 133 Xenon Inhalation. https://app.cochat.ai/papers/10.1161/01.str.6.3.245
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OBRIST, W. D., THOMPSON, H. K., WANG, H. S., & WILKINSON, W. E. (1975). Regional Cerebral Blood Flow Estimated by 133 Xenon Inhalation. Stroke. https://doi.org/10.1161/01.str.6.3.245

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.