Medullary arteries in aging and dementia.
Open accessAbstract
We examined sclerotic changes of the medullary arteries in 110 nonneuropsychiatric patients ranging in age from the second to the ninth decades, in 20 patients with subcortical arteriosclerotic encephalopathy (Binswanger's disease), and in 20 patients with dementia of the Alzheimer type. The principal sclerotic change was fibrohyaline thickening of the wall, which began to appear during the late fourth decade, increased in incidence gradually with age, and was most severe in patients with subcortical arteriosclerotic encephalopathy. Morphometry showed that the sclerotic changes of the medullary arteries were most prominent in the frontal lobe, followed by the parietal, occipital, and temporal lobes, in both the nonneuropsychiatric and demented groups. The sclerotic rate in the frontal lobe of patients with dementia of the Alzheimer type was slightly higher than that in the nonneuropsychiatric patients (p less than 0.05) but far less than that in the patients with subcortical arteriosclerotic encephalopathy (p less than 0.001). The sclerotic rate correlated well with the degree of ischemic white matter changes as well as with blood pressure.
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Other common vascular brain pathologies in older people include white matter degeneration and primary vessel disease such as arteriolosclerosis/lipohyalinosis, atherosclerosis, and cerebral amyloid angiopathy.
“There are other common vascular pathologies in the brains of older people, including white matter degeneration70,71 and primary vessel disease (ie, arteriolosclerosis/lipohyalinosis, atherosclerosis, and cerebral amyloid angiopathy [CAA]).70,72,73”
From Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2011) · cites this paper as [73]
The Discussion (page not available) says sclerotic medullary arteries are commonly seen in older people and that some are associated with diffuse ischemic white matter change. The Results (page not available) describe fibrohyaline thickening but state that atherosclerosis and amyloid angiopathy were not observed in the medullary arteries. This paper therefore supports part of the broad claim, not the full list of vessel diseases as common findings in its studied arteries. (LLM, conf=0.88)
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- Authors
- Furuta, A., Ishii, N., Nishihara, Y., & Horie, A.
- Affiliations
- University of Occupational and Environmental Health Japan (JP)
- ORCID
- Ishii, N
- Venue
- Stroke
- Published
- 1991-04
- Volume
- 22
- Issue
- 4
- Pages
- 442-446
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2081879060
- Cited by
- 185
- References
- 22
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 10 · 2018: 3 · 2017: 8 · 2016: 9 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- medullary arteries, cerebral arteriosclerosis, aging, dementia, Alzheimer's disease, subcortical arteriosclerotic encephalopathy, Binswanger disease, cerebral blood flow, blood pressure, frontal lobe, cerebral hemodynamics
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Arteriosclerosis, Blood Pressure, Cerebral Arteries, Female, Humans, Male, Medulla Oblongata, Middle Aged, Reference Values
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