The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion.
Open accessAbstract
Polymorphonuclear leukocytes have been implicated in the development of the "no-reflow" phenomenon after focal cerebral ischemia and reperfusion. To further understand the role of granulocytes in microvascular occlusions, the responses of the granulocyte-endothelial cell adhesion molecules P-selectin and intercellular adhesion molecule-1 during middle cerebral artery ischemia and reperfusion were examined in a primate model. Twelve adolescent male baboons were used for 2-hour middle cerebral artery occlusion (n = 3) or for 3-hour occlusion with 1-hour (n = 3), 4-hour (n = 3), and 24-hour (n = 3) reperfusion, and three separate unoperated primates served as controls. A quantitative immunohistochemical study of the microvascular distribution of P-selectin and intercellular adhesion molecule-1 was performed using 10-microns frozen sections from basal ganglia analyzed with computerized light microscopy video imaging. Significant (P < .05) persistent upregulation of P-selectin (beginning during ischemia) and transient upregulation of intercellular adhesion molecule-1 (at 1 and 4 hours of reperfusion) were observed on endothelium of selected post-capillary microvessels of the ischemic lenticulostriate artery territory. Platelet accumulation also occurred in this territory and was responsible for a significant proportion of the nonendothelial P-selectin signal at 24 hours after reperfusion. Focal cerebral ischemia/reperfusion stimulates endothelial P-selectin and intercellular adhesion molecule-1 expression in brain microvessels in the ischemic zone, which may contribute to enhanced leukocyte adherence and persistent activation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Warwick, R., Williams, P. L., Dyson, M., & Bannister, L. (1985) · The British Journal of Radiology · doi:10.1259/0007-1285-58-694-1029 · Cited by 4,532
Dustin, M. L., Rothlein, R., Bhan, A. K., Dinarello, C. A., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.1.245 · Cited by 2,450
Johnson, D. A., Gautsch, J. W., Sportsman, J. R., & Elder, J. H. (1984) · Gene Analysis Techniques · doi:10.1016/0735-0651(84)90049-9 · Cited by 1,672
A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.
Rothlein, R., Dustin, M. L., Marlin, S. D., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.4.1270 · Cited by 1,400
McEver, R. P., Beckstead, J. H., Moore, K. L., Marshall-Carlson, L., & Bainton, D. F. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114175 · Cited by 973
Rapid neutrophil adhesion to activated endothelium mediated by GMP-140
Geng, J.-G., Bevilacquat, M. P., Moore, K. L., Mclntyre, T. M., Prescott, S. M., Kim, J. M., Bliss, G. A., Zimmerman, G. A., & McEver, R. P. (1990) · Nature · doi:10.1038/343757a0 · Cited by 956
von Andrian, U. H., Chambers, J. D., McEvoy, L. M., Bargatze, R. F., Arfors, K. E., & Butcher, E. C. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7538 · Cited by 953
ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).
Diamond, M. S., Staunton, D. E., de Fougerolles, A. R., Stacker, S. A., Garcia-Aguilar, J., Hibbs, M. L., & Springer, T. A. (1990) · The Journal of cell biology · doi:10.1083/jcb.111.6.3129 · Cited by 880
Larsen, E., Celi, A., Gilbert, G. E., Furie, B. C., Erban, J. K., Bonfanti, R., Wagner, D. D., & Furie, B. (1989) · Cell · doi:10.1016/0092-8674(89)90292-4 · Cited by 864
Palabrica, T., Lobb, R., Furie, B. C., Aronovitz, M., Benjamin, C., Hsu, Y.-M., Sajer, S. A., & Furie, B. (1992) · Nature · doi:10.1038/359848a0 · Cited by 808
Cited by
Inflammation in stroke and focal cerebral ischemia
Huang, J., Upadhyay, U. M., & Tamargo, R. J. (2006) · Surgical Neurology · doi:10.1016/j.surneu.2005.12.028 · Cited by 649
Cerebral Ischemia-Hypoxia Induces Intravascular Coagulation and Autophagy
Adhami, F., Liao, G., Morozov, Y. M., Schloemer, A., Schmithorst, V. J., Lorenz, J. N., Dunn, R. S., Vorhees, C. V., Wills-Karp, M., Degen, J. L., et al. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.051066 · Cited by 326
Guido, S., Sebastian, J., & Schroeter, M. (2003) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4615-0123-7_3 · Cited by 276
Endothelial ICAM-1 Expression Associated With Inflammatory Cell Response in Human Ischemic Stroke
Lindsberg, P. J., Carpe´n, O., Paetau, A., Karjalainen-Lindsberg, M.-L., & Kaste, M. (1996) · Circulation · doi:10.1161/01.cir.94.5.939 · Cited by 275
Effects of the Chemokine CCL2 on Blood–Brain Barrier Permeability during Ischemia–Reperfusion Injury
Dimitrijevic, O. B., Stamatovic, S. M., Keep, R. F., & Andjelkovic, A. V. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600229 · Cited by 252
Metadata
- Authors
- Okada, Y., Copeland, B. R., Mori, E., Tung, M. M., Thomas, W. S., & del Zoppo, G. J.
- Venue
- Stroke
- Published
- 1994-01
- Volume
- 25
- Issue
- 1
- Pages
- 202-211
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2104371820
- Cited by
- 435
- References
- 42
- FWCI
- 25.92
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion. https://app.cochat.ai/papers/10.1161/01.str.25.1.202
- The paper
- Okada, Y., Copeland, B. R., Mori, E., Tung, M. M., Thomas, W. S., & del Zoppo, G. J. (1994). P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion. Stroke. https://doi.org/10.1161/01.str.25.1.202
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
