The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Presence and Severity of Cerebral White Matter Lesions and Hypertension, Its Treatment, and Its Control: The ARIC Study
Abstract
Background and Purpose White matter lesions (WML) may result from cerebral hypoperfusion or ischemia. We investigated the association of WML with blood pressure, hypertension, and its treatment and control. Methods A random sample of 1920 participants aged 55 to 72 years in the Atherosclerosis Risk in Communities Study (ARIC) was examined. Spin-density 1.5-T MRI scan images were coded from 0 for normal to 9 for most severe WML. Hypertension was defined as systolic or diastolic pressure ≥140/90 mm Hg or use of antihypertensive medication. Results The percentages of persons with WML grades 0 through 2 and 3 through 9, respectively, were as follows: normotensive, 92.4% and 7.6%, versus all hypertensive subjects, 83% and 17% ( P <.001); and treated controlled hypertensive, 86% and 14%, versus treated uncontrolled hypertensive subjects, 76% and 24% ( P =.003). Multivariable adjusted odds ratios (95% confidence intervals) for WML grade ≥3 relative to normotensive subjects was 2.34 (1.71 to 3.20) for all hypertensives, 1.99 (1.19 to 3.08) for untreated hypertensives, 1.94 (1.32 to 2.85) for treated controlled hypertensives, and 3.40 (2.30 to 5.03) for treated uncontrolled hypertensives. After additional adjustment for hypertension duration, treatment, and control status, the odds ratios (95% confidence intervals) for a 1 SD increase of systolic and diastolic blood pressure were 1.43 (1.11 to 1.85) and 1.16 (0.94 to 1.43), respectively. Conclusions Hypertension is associated with increased odds of WML, and treated uncontrolled hypertensive subjects have greater odds of WML than those with treated controlled hypertension. The data suggest that the level of blood pressure, especially systolic blood pressure, is related to WML, additional to the effects of categorically defined hypertension and its treatment and control status.
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Citations
Cites
(1989) · PubMed · Cited by 3,139
THE ATHEROSCLEROSIS RISK IN COMMUNIT (ARIC) STUDY: DESIGN AND OBJECTIVES
THE ARIC INVESTIGATORS (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115184 · Cited by 2,924
Breteler, M. M. B., van Swieten, J. C., Bots, M. L., Grobbee, D. E., Claus, J. J., van den Hout, J. H. W., van Harskamp, F., Tanghe, H. L. J., de Jong, P. T. V. M., van Gijn, J., et al. (1994) · Neurology · doi:10.1212/wnl.44.7.1246 · Cited by 1,006
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Manolio, T. A., Kronmal, R. A., Burke, G. L., Poirier, V, O'Leary, D. H., Gardin, J. M., Fried, L. P., Steinberg, E. P., & Bryan, R. N. (1994) · Stroke · doi:10.1161/01.str.25.2.318 · Cited by 458
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Liao, D., Cooper, L., Cai, J., Toole, J., Bryan, N., Burke, G., Shahar, E., Nieto, J., Mosley, T., & Heiss, G. (2014) · Neuroepidemiology · doi:10.1159/000368814 · Cited by 429
Self-citationBoone, K. B. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530290141024 · Cited by 400
Cerebral white matter lesions and atherosclerosis in the Rotterdam Study
Bots, M. L., Breteler, M. M. B., Hofman, A., Grobbee, D. E., van Swieten, J. C., van Gijn, J., van Swieten, J. C., & de Jong, P. T. V. M. (1993) · The Lancet · doi:10.1016/0140-6736(93)91144-b · Cited by 361
Hypertension in the elderly is associated with white matter lesions and cognitive decline
van Swieten, J. C., Geyskes, G. G., Derix, M. M. A., Peeck, B. M., Ramos, L. M. P., van Latum, J. C., & van Gijn, J. (1991) · Annals of Neurology · doi:10.1002/ana.410300612 · Cited by 285
Cited by
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000065 · Cited by 7,391
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.006 · Cited by 6,616
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., et al. (2013) · Journal of Hypertension · doi:10.1097/01.hjh.0000431740.32696.cc · Cited by 5,655
Authors/Task Force Members:, Mancia, G., De Backer, G., Dominiczak, A., Cifkova, R., Fagard, R., Germano, G., Grassi, G., Heagerty, A. M., Kjeldsen, S. E., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehm236 · Cited by 2,384
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
Umemura, S., Arima, H., Arima, S., Asayama, K., Dohi, Y., Hirooka, Y., Horio, T., Hoshide, S., Ikeda, S., Ishimitsu, T., et al. (2019) · Hypertension Research · doi:10.1038/s41440-019-0284-9 · Cited by 1,880
Metadata
- Authors
- Liao, D., Cooper, L., Cai, J., Toole, J. F., Bryan, N. R., Hutchinson, R. G., & Tyroler, H. A.
- Venue
- Stroke
- Published
- 1996-12
- Volume
- 27
- Issue
- 12
- Pages
- 2262-2270
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2117841533
- Cited by
- 450
- References
- 20
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
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