The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Diffusion-Weighted Imaging Discriminates Between Cytotoxic and Vasogenic Edema in a Patient With Eclampsia
Abstract
Background The pathophysiology of eclampsia remains unclear. While the majority of patients develop reversible T2 hyperintense signal abnormalities on MR scans and reversible neurological deficits, some patients do develop infarctions (permanent T2 hyperintense abnormalities) and permanent neurological impairment. Routine MRI cannot prospectively differentiate between these two patient groups. Echo-planar diffusion-weighted imaging, however, is a new technique that clearly differentiates between cytotoxic and vasogenic edema. Case Description A 30-year-old woman developed symptoms consistent with eclampsia 24 hours after delivering premature twins. An MRI demonstrated extensive, diffuse T2 hyperintense signal abnormalities involving subcortical white matter and adjacent gray matter with a posterior predominance, consistent with either infarction or hypertensive ischemic encephalopathy. Diffusion-weighted images demonstrated increased diffusion, consistent with vasogenic edema and hypertensive ischemic encephalopathy. Conclusions Unlike routine MRI, diffusion-weighted imaging reliably differentiates between vasogenic edema and cytotoxic edema. Consequently, in eclamptic patients diffusion-weighted imaging can afford clear differentiation between hypertensive ischemic encephalopathy and infarction, two very different entities with very different treatment protocols. Diffusion-weighted imaging should be performed in all eclamptic patients and should greatly affect their management.
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Cites
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Cited by
Diffusion tensor imaging: Concepts and applications
Le Bihan, D., Mangin, J., Poupon, C., Clark, C. A., Pappata, S., Molko, N., & Chabriat, H. (2001) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.1076 · Cited by 3,547
Looking into the functional architecture of the brain with diffusion MRI.
Le Bihan, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1119 · Cited by 1,571
Diffusion-weighted MR Imaging of the Brain
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Self-citationDiffusion MRI at 25: exploring brain tissue structure and function
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Metadata
- Authors
- Schaefer, P. W., Buonanno, F. S., Gonzalez, R. G., & Schwamm, L. H.
- Venue
- Stroke
- Published
- 1997-05
- Volume
- 28
- Issue
- 5
- Pages
- 1082-1085
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W1978621158
- Cited by
- 347
- References
- 9
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Diffusion-Weighted Imaging Discriminates Between Cytotoxic and Vasogenic Edema in a Patient With Eclampsia. https://app.cochat.ai/papers/10.1161/01.str.28.5.1082
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- Schaefer, P. W., Buonanno, F. S., Gonzalez, R. G., & Schwamm, L. H. (1997). Diffusion-Weighted Imaging Discriminates Between Cytotoxic and Vasogenic Edema in a Patient With Eclampsia. Stroke. https://doi.org/10.1161/01.str.28.5.1082
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