The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Expanding the Window for Thrombolytic Therapy in Acute Stroke: The Potential Role of Acute MRI for Patient Selection
Abstract
Background —Effective therapy was not available for treatment of acute stroke until 1995, when tissue plasminogen activator (tPA) was shown to improve neurological and functional outcome in stroke patients who were treated within 3 hours of symptom onset. Summary of Review —Currently, many patients do not qualify for tPA therapy because they present for evaluation beyond 3 hours after stroke onset. Attempts to expand the treatment window to 6 hours, using CT to select patients, have failed. Use of early MR imaging may provide significant advantages over CT for identification of patients who are likely to benefit from thrombolytic therapy because (1) the early perfusion-weighted imaging (PWI) lesion estimates the region of acute dysfunctional brain tissue, whereas the acute diffusion-weighted imaging (DWI) lesion appears to correspond to the core of the early infarction; (2) the mismatch between the acute PWI lesion and the smaller DWI lesion represents potentially salvageable brain tissue (an estimate of the ischemic penumbra); and (3) in patients with a PWI/DWI mismatch, early reperfusion is often associated with substantial clinical improvement and reversal or reduction of DWI lesion growth. Conclusions —Clinical trials that use new MRI techniques to screen patients may be able to identify a subset of acute stroke patients who are ideal candidates for thrombolytic therapy even beyond 3 hours after stroke onset.
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Cites
Tissue Plasminogen Activator for Acute Ischemic Stroke
(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654
Hacke, W., Kaste, M., Fieschi, C., von Kummer, R., Davalos, A., Meier, D., Larrue, V., Bluhmki, E., Davis, S., Donnan, G., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)08020-9 · Cited by 3,662
Moseley, M. E., Cohen, Y., Mintorovitch, J., Chileuitt, L., Shimizu, H., Kucharczyk, J., Wendland, M. F., & Weinstein, P. R. (1990) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910140218 · Cited by 1,644
(2024) · American Journal of Neuroradiology · doi:10.3174/ajnr.45-12.s8 · Cited by 890
Adams, H. P., Brott, T. G., Furlan, A. J., Gomez, C. R., Grotta, J., Helgason, C. M., Kwiatkowski, T., Lyden, P. D., Marler, J. R., Torner, J., et al. (1996) · Circulation · doi:10.1161/01.cir.94.5.1167 · Cited by 730
Antithrombotic and Thrombolytic Therapy for Ischemic Stroke
Albers, G. W., Easton, J. D., Sacco, R. L., & Teal, P. (1998) · Chest · doi:10.1378/chest.114.5_supplement.683s · Cited by 617
Self-citationAcute stroke: usefulness of early CT findings before thrombolytic therapy.
von Kummer, R., Allen, K. L., Holle, R., Bozzao, L., Bastianello, S., Manelfe, C., Bluhmki, E., Ringleb, P., Meier, D. H., & Hacke, W. (1997) · Radiology · doi:10.1148/radiology.205.2.9356611 · Cited by 587
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Prediction of stroke outcome with echoplanar perfusion- and diffusion-weighted MRI
Barber, P. A., Darby, D. G., Desmond, P. M., Yang, Q., Gerraty, R. P., Jolley, D., Donnan, G. A., Tress, B. M., & Davis, S. M. (1998) · Neurology · doi:10.1212/wnl.51.2.418 · Cited by 559
Cited by
Higashida, R. T., & Furlan, A. J. (2003) · Stroke · doi:10.1161/01.str.0000082721.62796.09 · Cited by 1,543
Demaerschalk, B. M., Kleindorfer, D. O., Adeoye, O. M., Demchuk, A. M., Fugate, J. E., Grotta, J. C., Khalessi, A. A., Levy, E. I., Palesch, Y. Y., Prabhakaran, S., et al. (2016) · Stroke · doi:10.1161/str.0000000000000086 · Cited by 670
Parsons, M. W., Barber, P. A., Desmond, P. M., Baird, T. A., Darby, D. G., Byrnes, G., Tress, B. M., & Davis, S. M. (2002) · Annals of Neurology · doi:10.1002/ana.10241 · Cited by 606
Comparative Overview of Brain Perfusion Imaging Techniques
Wintermark, M., Sesay, M., Barbier, E., Borbély, K., Dillon, W. P., Eastwood, J. D., Glenn, T. C., Grandin, C. B., Pedraza, S., Soustiel, J.-F., et al. (2005) · Stroke · doi:10.1161/01.str.0000177884.72657.8b · Cited by 592
Antithrombotic and Thrombolytic Therapy for Ischemic Stroke
Albers, G. W., Amarenco, P., Easton, J. D., Sacco, R. L., & Teal, P. (2004) · Chest · doi:10.1378/chest.126.3_suppl.483s · Cited by 466
Self-citation
Metadata
- Authors
- Albers, G. W.
- Venue
- Stroke
- Published
- 1999-10
- Volume
- 30
- Issue
- 10
- Pages
- 2230-2237
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2021463269
- Cited by
- 253
- References
- 51
- FWCI
- 17.10
- Type
- journal article
- Language
- en
- Open access
- closed
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