Plasticity of Language-Related Brain Function During Recovery From Stroke
Open accessAbstract
Background and Purpose —This study was undertaken to correlate functional recovery from aphasia after acute stroke with the temporal evolution of the anatomic, physiological, and functional changes as measured by MRI. Methods —Blood oxygenation level–dependent contrast and echo-planar MRI were used to map language comprehension in 6 normal adults and in 2 adult patients during recovery from acute stroke presenting with aphasia. Perfusion, diffusion, sodium, and conventional anatomic MRI were used to follow physiological and structural changes. Results —The normal activation pattern for language comprehension showed activation predominately in left-sided Wernicke’s and Broca’s areas, with laterality ratios of 0.8 and 0.3, respectively. Recovery of the patient confirmed as having a completed stroke affecting Broca’s area occurred rapidly with a shift of activation to the homologous region in the right hemisphere within 3 days, with continued rightward lateralization over 6 months. In the second patient, in whom mapping was performed fortuitously before stroke, recovery of a Wernicke’s aphasia showed a similar increasing rightward shift in activation recruitment over 9 months after the event. Conclusions —Recovery of aphasia in adults can occur rapidly and is concomitant with an activation pattern that changes from left to a homologous right hemispheric pattern. Such recovery occurs even when the stroke evolves to completion. Such plasticity must be considered when evaluating stroke interventions based on behavioral and neurological measurements.
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Previous research on recovery of function after brain injury has shown that, in the face of left hemisphere damage, the right hemisphere can increase its activity in a compensatory manner.
“Previous research on recovery of function after brain injury has shown that, in the face of left hemisphere damage, the right hemisphere can increase its activity in a compensatory manner (16–18).”
From Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI (2003) · cites this paper as [18]
The results are consistent with studies of recovery of function after left hemisphere damage showing increased activity in right hemisphere homologues of left hemisphere language areas associated with improved language ability.
“These results are consistent with studies of recovery of function after left hemisphere damage that have shown increased activity in right hemisphere homologues of left hemisphere language areas associated with improved language ability (16–18).”
From Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI (2003) · cites this paper as [18]
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- Authors
- Thulborn, K. R., Carpenter, P. A., & Just, M. A.
- Affiliations
- University of Pittsburgh Medical Center (US)
- Venue
- Stroke
- Published
- 1999-04
- Volume
- 30
- Issue
- 4
- Pages
- 749-754
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2032187014
- Cited by
- 402
- References
- 25
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 6 · 2018: 9 · 2017: 15 · 2016: 18 · 2015: 13 · 2014: 11 · 2013: 15 · 2012: 14
- FWCI
- 13.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- KiltHub Repository (submittedVersion)
- KiltHub Repository
- Funders
- National Institutes of Health (5r01ca063661-03)
- National Institute of Mental Health (MH 00661)
- National Cancer Institute (PHS-RO1-CA63661)
- National Institute of Neurological Disorders and Stroke (PHS-PO1-NS35949, P01NS035949)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- aphasia, stroke recovery, neuroplasticity, language comprehension, hemispheric lateralization, Wernicke's area, Broca's area, right hemisphere activation, functional MRI, perfusion MRI, diffusion MRI, sodium MRI
- MeSH terms
- Adult, Aphasia, Wernicke, Cerebral Infarction, Cerebrovascular Disorders, Epilepsy, Temporal Lobe, Frontal Lobe, Humans, Language, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Neuronal Plasticity, Reading, Temporal Lobe, Treatment Outcome
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