The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
C-Reactive Protein and Outcome After Ischemic Stroke
Abstract
Background and Purpose —Elevated concentrations of the acute-phase reactant C-reactive protein (CRP) predict ischemic cardiac events in both hospital- and population-based studies and may signify a role for inflammation in the destabilization of cardiovascular disease. We examined the relationship between CRP and outcome after acute ischemic stroke. Methods —This was a subgroup analysis from a prospective observational study based in a University Hospital Acute Stroke Unit serving a population of ≈260 000. Survival time and cause of death for up to 4 years after the index stroke were determined and related to CRP concentration within 72 hours of stroke and known prognostic variables by a Cox proportional hazards regression model. Results —Ischemic stroke was diagnosed in 228 of 283 consecutive admissions. Median follow-up was 959 days. Geometric mean CRP concentration was 10.1 mg/L. Survival in those with CRP >10.1 mg/L was significantly worse than in those with CRP ≤10.1 mg/L ( P =0.00009, log-rank test). Higher CRP concentration was an independent predictor of mortality (hazard ratio, 1.23 per additional natural log unit; 95% CI, 1.13 to 1.35; P =0.02), together with age and stroke severity on the National Institutes of Health Stroke Scale. Cardiovascular disease accounted for 76% of deaths in those with CRP >10.1 mg/L and 63% of deaths in those with CRP ≤10.1 mg/L. Conclusions —CRP concentration is an independent predictor of survival after ischemic stroke. These findings are consistent with a role for inflammation in acute ischemic stroke, as well as with the hypothesis that elevated CRP may predict future cardiovascular mortality.
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The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina
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Cited by
C-Reactive Protein Levels Correlate With Mortality and Organ Failure in Critically Ill Patientsa
Lobo, S. M. A., Lobo, F. R. M., Bota, D. P., Lopes-Ferreira, F., Soliman, H. M., Meélot, C., & Vincent, J.-L. (2003) · Chest · doi:10.1378/chest.123.6.2043 · Cited by 448
C-Reactive Protein in Ischemic Stroke: An Independent Prognostic Factor
Di Napoli, M., Papa, F., & Bocola, V. (2001) · Stroke · doi:10.1161/01.str.32.4.917 · Cited by 389
McColl, B. W., Rothwell, N. J., & Allan, S. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5376-06.2007 · Cited by 337
Spalletta, G., Bossù, P., Ciaramella, A., Bria, P., Caltagirone, C., & Robinson, R. G. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001879 · Cited by 290
C‐Reactive Protein (CRP)‐Lowering Agents
Prasad, K. (2006) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2006.00033.x · Cited by 272
Metadata
- Authors
- Muir, K. W., Weir, C. J., Alwan, W., Squire, I. B., & Lees, K. R.
- Venue
- Stroke
- Published
- 1999-05
- Volume
- 30
- Issue
- 5
- Pages
- 981-985
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2102512891
- Cited by
- 317
- References
- 25
- FWCI
- 12.50
- Type
- journal article
- Language
- en
- Open access
- closed
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