Atrial Fibrillation and Stroke: Concepts and Controversies

Secondary prevention in non-rheumatic atrial fibrillation after transient ischaemic attack or minor stroke

EAFT (European Atrial Fibrillation Trial) Study Group (1993) · The Lancet · doi:10.1016/0140-6736(93)92358-z · Cited by 1,877

PLACEBO-CONTROLLED, RANDOMISED TRIAL OF WARFARIN AND ASPIRIN FOR PREVENTION OF THROMBOEMBOLIC COMPLICATIONS IN CHRONIC ATRIAL FIBRILLATION

Petersen, P., GODTFREDSEN, J., Boysen, G., Andersen, E. D., & Andersen, B. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91200-2 · Cited by 1,814

Stroke Prevention in Atrial Fibrillation Study. Final results.

Prevention, S., & Atrial Fibrillation Investigators (1991) · Circulation · doi:10.1161/01.cir.84.2.527 · Cited by 1,696

Antithrombotic Therapy To Prevent Stroke in Patients with Atrial Fibrillation

Hart, R. G., Benavente, O., McBride, R., & Pearce, L. A. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-7-199910050-00003 · Cited by 1,636

The Effect of Low-Dose Warfarin on the Risk of Stroke in Patients with Nonrheumatic Atrial Fibrillation

The Boston Area Anticoagulation Trial for Atrial Fibrillation Investigators* (1990) · New England Journal of Medicine · doi:10.1056/nejm199011293232201 · Cited by 1,525

Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation: Stroke Prevention in Atrial Fibrillation III randomised clinical trial

(1996) · The Lancet · doi:10.1016/s0140-6736(96)03487-3 · Cited by 1,085

Risk Factors for Intracranial Hemorrhage in Outpatients Taking Warfarin

Hylek, E. M., & Singer, D. E. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-120-11-199406010-00001 · Cited by 915

An Analysis of the Lowest Effective Intensity of Prophylactic Anticoagulation for Patients with Nonrheumatic Atrial Fibrillation

Hylek, E. M., Skates, S. J., Sheehan, M. A., & Singer, D. E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199608223350802 · Cited by 789

Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy

Hart, R. G., Pearce, L. A., Rothbart, R. M., McAnulty, J. H., ASINGER, R. W., & Halperin, J. L. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00489-1 · Cited by 662

Warfarin Use among Ambulatory Patients with Nonvalvular Atrial Fibrillation: The AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study

Go, A. S., Hylek, E. M., Borowsky, L. H., Phillips, K. A., Selby, J. V., & Singer, D. E. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-12-199912210-00004 · Cited by 586

ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): Developed in Collaboration With the European Heart Rhythm Association and the Heart Rhythm Society

Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Le Heuzey, J.-Y., Kay, G. N., Lowe, J. E., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.177292 · Cited by 2,805

New ideas about atrial fibrillation 50 years on

Nattel, S. (2002) · Nature · doi:10.1038/415219a · Cited by 1,481

ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation—Executive Summary

Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.009 · Cited by 1,161

Contribution of Atrial Fibrillation to Incidence and Outcome of Ischemic Stroke: Results From a Population-Based Study

Marini, C., De Santis, F., Sacco, S., Russo, T., Olivieri, L., Totaro, R., & Carolei, A. (2005) · Stroke · doi:10.1161/01.str.0000166053.83476.4a · Cited by 949

2011 ACCF/AHA/HRS Focused Updates Incorporated Into the ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation

Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Kay, G. N., Huezey, J.-Y. L., Lowe, J. E., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.013 · Cited by 928

2011 ACCF/AHA/HRS Focused Updates Incorporated Into the ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

Fuster, V., Rydén, L. E., Cannom, D. S., Crijns, H. J., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Kay, G. N., Le Huezey, J.-Y., Lowe, J. E., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318214876d · Cited by 859

Oral Anticoagulants vs Aspirin in Nonvalvular Atrial Fibrillation

van Walraven, C., Hart, R. G., Singer, D. E., Laupacis, A., Connolly, S. J., Petersen, P., Koudstaal, P. J., Chang, Y., & Hellemons, B. S. P. (2002) · JAMA · doi:10.1001/jama.288.19.2441 · Cited by 715

ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text

Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · EP Europace · doi:10.1093/europace/eul097 · Cited by 670

ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation–executive summary

Authors Task Force Members, Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl176 · Cited by 646

ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation

Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.018 · Cited by 468

Severe Sleep Apnea and Risk of Ischemic Stroke in the Elderly

Muñóz, R., Durán‐Cantolla, J., Martínez‐Vila, E., Gállego, J., Rubio, R., Aizpuru, F., & Torre, G. D. L. (2006) · Stroke · doi:10.1161/01.str.0000236560.15735.0f · Cited by 416

Percutaneous Left Atrial Appendage Suture Ligation Using the LARIAT Device in Patients With Atrial Fibrillation

Bartuś, K., Han, F. T., Bednarek, J., Myć, J., Kapelak, B., Sadowski, J., Lelakowski, J., Bartuś, S., Yakubov, S. J., & Lee, R. J. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.06.046 · Cited by 412

Downregulation of Endocardial Nitric Oxide Synthase Expression and Nitric Oxide Production in Atrial Fibrillation

Cai, H. “., Li, Z., Goette, A., Mera, F. V., Honeycutt, C., Feterik, K., Wilcox, J. N., Dudley, S. C., Harrison, D. G., & Langberg, J. J. (2002) · Circulation · doi:10.1161/01.cir.0000039327.11661.16 · Cited by 367

Status of the Epidemiology of Atrial Fibrillation

Kannel, W. B., & Benjamin, E. J. (2007) · Medical Clinics of North America · doi:10.1016/j.mcna.2007.09.002 · Cited by 359

ACC/AHA/ESC 2006 Guidelines for the Management of Patients With Atrial Fibrillation—Executive Summary

Fuster, V., Rydén, L., Cannom, D. S., Crijns, H. J. G. M., Curtis, A. B., Ellenbogen, K. A., Halperin, J. L., Heuzey, J. L., Kay, G. N., Lowe, J. E., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.177031 · Cited by 345

Endothelin-1–Induced Arrhythmogenic Ca 2+ Signaling Is Abolished in Atrial Myocytes of Inositol-1,4,5-Trisphosphate(IP 3 )–Receptor Type 2–Deficient Mice

Li, X., Zima, A. V., Sheikh, F., Blatter, L. A., & Chen, J. (2005) · Circulation Research · doi:10.1161/01.res.0000172556.05576.4c · Cited by 333

2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry

Steinberg, J. S., Varma, N., Cygankiewicz, I., Aziz, P., Balsam, P., Baranchuk, A., Cantillon, D. J., Dilaveris, P., Dubner, S. J., El-Sherif, N., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.038 · Cited by 303

Relationship of interleukin-6 and C-Reactive protein to the prothrombotic state in chronic atrial fibrillation

Conway, D., Buggins, P., Hughes, E. A., & Lip, G. Y. H. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.11.062 · Cited by 280

Prognostic Value of Plasma von Willebrand Factor and Soluble P-Selectin as Indices of Endothelial Damage and Platelet Activation in 994 Patients With Nonvalvular Atrial Fibrillation

Conway, D., Pearce, L. A., Chin, B., Hart, R. G., & Lip, G. Y. H. (2003) · Circulation · doi:10.1161/01.cir.0000077912.12202.fc · Cited by 269

Patent foramen ovale

Homma, S., Messe, S. R., Rundek, T., Sun, Y., Franke, J., Davidson, K. W., Sievert, H., Sacco, R. L., & Tullio, M. R. D. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.86 · Cited by 209

Optimizing postoperative outcomes with efficient preoperative assessment and management

Halaszynski, T. M., Juda, R., & Silverman, D. G. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000122046.30687.5c · Cited by 199

Leukoaraiosis is associated with warfarin-related hemorrhage following ischemic stroke

Smith, E. E., Rosand, J. M., Knudsen, K. A., Hylek, E. M., & Greenberg, S. M. (2002) · Neurology · doi:10.1212/wnl.59.2.193 · Cited by 193

Plasma von Willebrand Factor and Soluble P-Selectin as Indices of Endothelial Damage and Platelet Activation in 1321 Patients With Nonvalvular Atrial Fibrillation

Conway, D., Pearce, L. A., Chin, B., Hart, R. G., & Lip, G. Y. H. (2002) · Circulation · doi:10.1161/01.cir.0000033220.97592.9a · Cited by 194

Efficacy and Safety of Apixaban Compared with Warfarin for Stroke Prevention in Patients with Atrial Fibrillation from East Asia: A Subanalysis of the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial

Goto, S., Zhu, J., Liu, L., Oh, B., WOJDYLA, D. M., Aylward, P. E., Bahit, M. C., Gersh, B. J., Hanna, M., Horowitz, J. D., et al. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.06.005 · Cited by 164

Local calcium gradients during excitation–contraction coupling and alternans in atrial myocytes

Blatter, L. A., Kockskämper, J., Sheehan, K. A., Zima, A. V., Hüser, J., & Lipsius, S. L. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.025239 · Cited by 162

Effects of Antiarrhythmic Drugs on Fibrillation in the Remodeled Atrium

Shinagawa, K., Shiroshita-Takeshita, A., Schram, G., & Nattel, S. (2003) · Circulation · doi:10.1161/01.cir.0000055316.35552.74 · Cited by 160

Current Perceptions of the Epidemiology of Atrial Fibrillation

Kannel, W. B., & Benjamin, E. J. (2008) · Cardiology Clinics · doi:10.1016/j.ccl.2008.09.015 · Cited by 138

Ambulatory External Electrocardiographic Monitoring

Mittal, S., Movsowitz, C., & Steinberg, J. S. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.07.026 · Cited by 136

Cardiogenic and Aortogenic Brain Embolism

Doufekias, E., Segal, A. Z., & Kizer, J. R. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.11.053 · Cited by 128

Extracranial Systemic Embolic Events in Patients With Nonvalvular Atrial Fibrillation

Bekwelem, W., Connolly, S. J., Halperin, J. L., Adabağ, S., Duval, S., Chrolavicius, S., Pogue, J. M., Ezekowitz, M. D., Eikelboom, J. W., Wallentin, L. C., et al. (2015) · Circulation · doi:10.1161/circulationaha.114.013243 · Cited by 122

Distribution territories and causative mechanisms of ischemic stroke

Rovira, À., Grivé, E., Rovira, À., & Álvarez‐Sabín, J. (2005) · European Radiology · doi:10.1007/s00330-004-2633-5 · Cited by 122

2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry

Steinberg, J. S., Varma, N., Cygankiewicz, I., Aziz, P. F., Balsam, P., Baranchuk, A. M., Cantillon, D. J., Dilaveris, P., Dubner, S., El‐Sherif, N., et al. (2017) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12447 · Cited by 123

Serious Adverse Vascular Events Associated With Perioperative Interruption of Antiplatelet and Anticoagulant Therapy

Alam, M., & Goldberg, L. H. (2002) · Dermatologic Surgery · doi:10.1046/j.1524-4725.2002.02085.x · Cited by 112

Effect of Obstructive Sleep Apnea on Frequency of Stroke in Patients With Atrial Fibrillation

YARANOV, D. M., Smyrlis, A., Usatii, N., Butler, A. D., Petrini, J. R., Mendez, J. L., & Warshofsky, M. K. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2014.11.027 · Cited by 109

Subcellular Ca2+ alternans represents a novel mechanism for the generation of arrhythmogenic Ca2+ waves in cat atrial myocytes

Kockskämper, J., & Blatter, L. A. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.025502 · Cited by 104

AI-Based Stroke Disease Prediction System Using ECG and PPG Bio-Signals

Yu, J., Park, S. J., Kwon, S., Cho, K. H., & Lee, H. (2022) · IEEE Access · doi:10.1109/access.2022.3169284 · Cited by 109

Therapeutic implications of atrial fibrillation mechanisms: can mechanistic insights be used to improve AF management?

Nattel, S. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00562-4 · Cited by 97

Use of Anticoagulation in Elderly Patients with Atrial Fibrillation Who Are at Risk for Falls

Garwood, C. L., & Corbett, T. L. (2008) · Annals of Pharmacotherapy · doi:10.1345/aph.1k498 · Cited by 95

Thrombomodulin and Tissue Factor Pathway Inhibitor in Endocardium of Rapidly Paced Rat Atria

Yamashita, T., Sekiguchi, A., Iwasaki, Y., Sagara, K., Hatano, S., Iinuma, H., Aizawa, T., & Fu, L.-T. (2003) · Circulation · doi:10.1161/01.cir.0000102969.09658.f2 · Cited by 93

Atrial Fibrillation and the Prothrombotic State in the Elderly

Conway, D., Heeringa, J., van der Kuip, D. A. M., Chin, B., Albert Hofman, D., Witteman, J. C. M., & Lip, G. Y. H. (2003) · Stroke · doi:10.1161/01.str.0000051728.85133.32 · Cited by 93

Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels

G�gelein, H., Brendel, J., Steinmeyer, K., Str�bing, C., Picard, N., Rampe, D., Kopp, K., Busch, A. E., & Bleich, M. (2004) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-004-0957-y · Cited by 90

Predicting left atrial thrombi in atrial fibrillation

Wysokiński, W. E., Ammash, N. M., Sobande, F., Kalsi, H., Hodge, D. O., & McBane, R. D. (2010) · American Heart Journal · doi:10.1016/j.ahj.2009.12.043 · Cited by 86

Periprocedural Anticoagulation Management of Patients With Nonvalvular Atrial Fibrillation

Wysokiński, W. E., McBane, R. D., Daniels, P. R., Litin, S. C., Hodge, D. O., Dowling, N. F., & Heit, J. A. (2008) · Mayo Clinic Proceedings · doi:10.4065/83.6.639 · Cited by 85

Elevated pro-inflammatory CD4 + CD28 − lymphocytes and stroke recurrence and death

Nadareishvili, Z., Li, H., Wright, V., Maric, D., Warach, S. J., Hallenbeck, J. M., Dambrosia, J., Barker, J. L., & Baird, A. E. (2004) · Neurology · doi:10.1212/01.wnl.0000142260.61443.7c · Cited by 84

A study of platelet activation in atrial fibrillation and the effects of antithrombotic therapy

Kamath, S. (2002) · European Heart Journal · doi:10.1053/euhj.2002.3259 · Cited by 83

Heart and vessel pathology underlying brain infarction in 142 stroke patients

Ogata, J., Yutani, C., Otsubo, R., Yamanishi, H., Naritomi, H., Yamaguchi, T., & Minematsu, K. (2008) · Annals of Neurology · doi:10.1002/ana.21401 · Cited by 78

Omega-3 Fatty Acids and Incident Ischemic Stroke and Its Atherothrombotic and Cardioembolic Subtypes in 3 US Cohorts

Saber, H., Yakoob, M. Y., Shi, P., Longstreth, W. T., Jr., Lemaître, R. N., Siscovick, D. S., Rexrode, K. M., Willett, W. C., & Mozaffarian, D. (2017) · Stroke · doi:10.1161/strokeaha.117.018235 · Cited by 79

Atrial arrhythmogenesis in obstructive sleep apnea: Therapeutic implications

Linz, D., Linz, B. M., Hohl, M., & Böhm, M. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.03.003 · Cited by 76

Assessment of left atrial appendage function with transthoracic tissue Doppler echocardiography

Uretsky, S., Shah, A., Bangalore, S., Rosenberg, L., Sarji, R., Cantales, D., Macmillan-Marrotti, D., Chaudhry, F. A., & Sherrid, M. V. (2009) · European Journal of Echocardiography · doi:10.1093/ejechocard/jen339 · Cited by 74

Atrial fibrillation and thrombosis: immunohistochemical differences between in situ and embolized thrombi

Wysokiński, W. E., Owen, W. G., Fass, D. N., Patrzałek, D., Murphy, L., & McBane, R. D. (2004) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2004.00899.x · Cited by 72

New Approaches to Atrial Fibrillation Management

Nattel, S., Khairy, P., Roy, D., Thibault, B., Guerra, P. G., Talajic, M. R., & Dubuc, M. (2002) · Drugs · doi:10.2165/00003495-200262160-00005 · Cited by 72

Ethnic Differences in Markers of Thrombophilia: Implications for the Investigation of Ischemic Stroke in Multiethnic Populations: The South London Ethnicity and Stroke Study

Jerrard-Dunne, P., Evans, A., McGovern, R., Hajat, C., Kalra, L., Rudd, A., Wolfe, C., & Markus, H. (2003) · Stroke · doi:10.1161/01.str.0000083049.65008.5f · Cited by 75

Trajectories of Oral Anticoagulation Adherence Among Medicare Beneficiaries Newly Diagnosed With Atrial Fibrillation

Hernandez, I., He, M., Chen, N., Brooks, M. M., Saba, S., & Gellad, W. F. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.011427 · Cited by 71

Atrial Fibrillation in the Elderly

Chatap, G., Giraud, K., & Vincent, J.-P. (2002) · Drugs & Aging · doi:10.2165/00002512-200219110-00002 · Cited by 70

The Khorasan Stroke Registry: Results of a Five-Year Hospital-Based Study

Ghandehari, K., & Izadi, Z. (2006) · Cerebrovascular Diseases · doi:10.1159/000097050 · Cited by 70

Paroxysmal Atrial Fibrillation Is More Prevalent than Persistent Atrial Fibrillation in Acute Stroke and Transient Ischemic Attack Patients

Rizos, T., Wagner, A., Jenetzky, E., Ringleb, P. A., Becker, R., Hacke, W., & Veltkamp, R. C. (2011) · Cerebrovascular Diseases · doi:10.1159/000330348 · Cited by 69

Increased Left Atrial Volume Index: Potent Biomarker for First-Ever Ischemic Stroke

Fatema, K., Bailey, K. R., Petty, G. W., Meissner, I., Osranek, M., Alsaileek, A. A., Khandheria, B. K., Tsang, T. S. M., & Seward, J. B. (2008) · Mayo Clinic Proceedings · doi:10.4065/83.10.1107 · Cited by 68

Frequency and Significance of Cardiac Sources of Embolism in the TOAST Classification

Han, S. W., Nam, H. S., Kim, S. H., Lee, J. Y., Lee, K., & Heo, J. H. (2007) · Cerebrovascular Diseases · doi:10.1159/000108438 · Cited by 65

Surface Atrial Frequency Analysis in Patients with Atrial Fibrillation:

Raine, D., Langley, P., Murray, A., Dunuwille, A., & Bourke, J. P. (2004) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2004.04032.x · Cited by 63

Relation of C-reactive protein correlates with risk of thromboembolism in patients with atrial fibrillation

Thambidorai, S. K., Parakh, K., Martin, D. O., Shah, T. K., Wazni, O. M., Jasper, S. E., Wagoner, D. R. V., Chung, M. K., Murray, R. D., & Klein, A. L. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.06.011 · Cited by 63

Digoxin use is associated with increased platelet and endothelial cell activation in patients with nonvalvular atrial fibrillation

Chirinos, J. A., Castrellon, A. B., Zambrano, J. P., Jimenez, J. J., Jy, W., Horstman, L. L., Willens, H. J., Castellanos, A., Myerburg, R. J., & Ahn, Y. S. (2005) · Heart Rhythm · doi:10.1016/j.hrthm.2005.01.016 · Cited by 61

Left Atrial Appendage Ligation in Nonvalvular Atrial Fibrillation Patients at High Risk for Embolic Events With Ineligibility for Oral Anticoagulation

Sievert, H., Rasekh, A., Bartus, K., Morelli, R., Fang, Q., Kuropka, J., Le, D. L., Gafoor, S. A., Heuer, L., Safavi‐Naeini, P., et al. (2015) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2015.08.005 · Cited by 55

In Vitro and In Vivo Effects of the Atrial Selective Antiarrhythmic Compound AVE1231

WIRTH, K. J., Brendel, J., Steinmeyer, K., Linz, D., Rütten, H., & Gögelein, H. (2007) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318032002f · Cited by 55

Video-Assisted Epicardial Ablation and Left Atrial Appendage Exclusion for Atrial Fibrillation: Extended Follow-Up

Wudel, J. H., Chaudhuri, P., & Hiller, J. J. (2007) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2007.08.014 · Cited by 55

Ligand Binding to the Voltage-Gated Kv1.5 Potassium Channel in the Open State—Docking and Computer Simulations of a Homology Model

Andér, M., Luzhkov, V. B., & Åqvist, J. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.112045 · Cited by 52

The development and implementation of stroke risk prediction model in National Health Insurance Service's personal health record

Lee, J.-W., Lim, H.-S., Kim, D.-W., Shin, S.-A., Kim, J., Yoo, B., & Cho, K.-H. (2018) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2017.10.007 · Cited by 49

Hyperhomocysteinemia Is Associated With the Presence of Left Atrial Thrombus in Stroke Patients With Nonvalvular Atrial Fibrillation

Ay, H., Arsava, E. M., Tokgozoglu, S. L., Özer, N., & Sarıbaş, O. (2003) · Stroke · doi:10.1161/01.str.0000060202.63475.ba · Cited by 46

Neurologic Manifestations of Cardiogenic Embolism

Palacio, S., & Hart, R. G. (2002) · Neurologic Clinics · doi:10.1016/s0733-8619(03)00058-6 · Cited by 47

New insights into the mechanisms and management of atrial fibrillation.

Khairy, P., & Nattel, S. (2002) · Europe PMC (PubMed Central) · Cited by 45

Risk of Stroke or Transient Ischemic Attack After Atrial Fibrillation Ablation with Oral Anticoagulant Use Guided by ECG Monitoring and Pulse Assessment

Riley, M. P., Zado, E. S., Hutchinson, M. D., Lin, D., Bala, R., Garcia, F. C., Callans, D. J., Cooper, J. M., Verdino, R. J., Dixit, S., et al. (2014) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.12387 · Cited by 44

Cardioembolic Stroke: An Update

Kelley, R. E., & Minagar, A. (2003) · Southern Medical Journal · doi:10.1097/01.smj.0000063471.13035.85 · Cited by 46

Role of echocardiography in patients with stroke

Nakanishi, K., & Homma, S. (2016) · Journal of Cardiology · doi:10.1016/j.jjcc.2016.05.001 · Cited by 44

Diabetic atrial fibrillation patients: mortality and risk for stroke or embolism during a 10‐year follow‐up

Klem, I., Wehinger, C., Schneider, B., Hartl, E., Finsterer, J., & Stöllberger, C. (2003) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.386 · Cited by 44

Brain natriuretic peptide is a marker associated with thrombus in stroke patients with atrial fibrillation

Okada, Y., Shibazaki, K., Kimura, K., Matsumoto, N., Iguchi, Y., Aoki, J., Kobayashi, K., & Sakai, K. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.10.017 · Cited by 43

Marine n-3 Polyunsaturated Fatty Acids and the Risk of Ischemic Stroke

Venø, S. K., Bork, C. S., Jakobsen, M. U., Lundbye‐Christensen, S., McLennan, P. L., Bach, F. W., Overvad, K., & Schmidt, E. B. (2019) · Stroke · doi:10.1161/strokeaha.118.023384 · Cited by 43

Characterization of a novel multifunctional resveratrol derivative for the treatment of atrial fibrillation

Baczkó, I., Liknes, D. A., Yang, W., Hamming, K. S. C., Searle, G. J., Jaeger, K., Husti, Z., Juhász, V., Klausz, G., Pap, R., et al. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12409 · Cited by 43

Hemodynamic Modulation of Endocardial Thromboresistance

Kapur, N. K., Deming, C., Kapur, S., Bian, C., Champion, H. C., Donahue, J. K., Kass, D. A., & Rade, J. J. (2006) · Circulation · doi:10.1161/circulationaha.106.640698 · Cited by 42

Large variations in the use of oral anticoagulants in stroke patients with atrial fibrillation: a Swedish national perspective

Glader, E., Stegmayr, B. G., Norrving, B. G., Terént, A., Hulter‐Åsberg, K., Wester, P. O., & Asplund, K. (2003) · Journal of Internal Medicine · doi:10.1046/j.0954-6820.2003.01253.x · Cited by 42

The association between atrial fibrillation and stroke in patients with obstructive sleep apnea: A population-based case-control study

Mansukhani, M. P., Calvin, A. D., Kolla, B. P., Brown, R. D., Lipford, M. C., Somers, V. K., & Caples, S. M. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2012.08.021 · Cited by 41

Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms

Lubitz, S. A., Parsons, O., Anderson, C. D., Benjamin, E. J., Malik, R., Weng, L.-C. C., Dichgans, M., Sudlow, C. L. M., Rothwell, P. M., Rosand, J. M., et al. (2017) · Stroke · doi:10.1161/strokeaha.116.016198 · Cited by 39

Nonchannel drug targets in atrial fibrillation

Goette, A., & Lendeckel, U. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.01.001 · Cited by 39

Development and Comparison of a Warfarin-Dosing Algorithm for Korean Patients With Atrial Fibrillation

Cho, H.-J., On, Y., Bang, O. Y., Kim, J., Huh, W., Ko, J., Kim, J. S., & Lee, S. (2011) · Clinical Therapeutics · doi:10.1016/j.clinthera.2011.09.004 · Cited by 39

Atherothrombotic ischemic stroke in patients with atrial fibrillation

Şenel, G. B., Uludüz, D., İnce, B., & Bozluolçay, M. (2007) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2007.03.009 · Cited by 39

Atrial Fibrillation

Valderrama, A. L., Dunbar, S. B., & Mensah, G. A. (2005) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2005.07.021 · Cited by 40

Clinical and Imaging Characteristics of Cerebral Infarction in Patients with Nonvalvular Atrial Fibrillation Combined with Cerebral Artery Stenosis

Sun, W., Li, G., Zeng, X., Lai, Z., Wang, M., Ouyang, Y., Zeng, G., Peng, J., Zhong, J., Xiao, D., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.43240 · Cited by 38

Role of oral anticoagulation in management of atrial fibrillation

Crystal, E., & Connolly, S. J. (2004) · Heart · doi:10.1136/hrt.2003.021642 · Cited by 38

Aging and atrial fibrillation: A vicious circle

Gao, P., Gao, X., Xie, B., Tse, G., & Liu, T. (2023) · International Journal of Cardiology · doi:10.1016/j.ijcard.2023.131445 · Cited by 40

Platelets: Small in Size But Essential in the Regulation of Vascular Homeostasis – Translation From Basic Science to Clinical Medicine –

Goto, S., Hasebe, T., & Takagi, S. (2015) · Circulation Journal · doi:10.1253/circj.cj-14-1434 · Cited by 36

Review: Role of cerebral vessels in ischaemic injury of the brain

Ogata, J., Yamanishi, H., & Ishibashi‐Ueda, H. (2010) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2010.01141.x · Cited by 36

Difference in Infarct Volume and Patterns between Cardioembolism and Internal Carotid Artery Disease: Focus on the Degree of Cardioembolic Risk and Carotid Stenosis

Jung, J., Kwon, S. U., Lee, J., & Kang, D. (2010) · Cerebrovascular Diseases · doi:10.1159/000297965 · Cited by 36

Khorasan stroke registry: analysis of 1392 stroke patients.

Ghandehari, K., & Mood, Z. I. (2007) · PubMed · Cited by 36

Newly diagnosed atrial fibrillation linked to wake-up stroke and TIA

Riccio, P. M., Klein, F., Cassará, F. P., Giacomelli, F. M., Toledo, M. E. G., Racosta, J. M., Delfitto, M., Roberts, E., Bahit, M. C., & Sposato, L. A. (2013) · Neurology · doi:10.1212/wnl.0b013e318292a330 · Cited by 34

Effects of antiarrhythmic drug therapy on atrioventricular nodal function during atrial fibrillation in humans*

Mangin, L., Vinet, A., Pagé, P., & Glass, L. (2005) · EP Europace · doi:10.1016/j.eupc.2005.03.016 · Cited by 34

Prevention of stroke in patients with atrial fibrillation: current strategies and future directions

Hohnloser, S. H., Duray, G. Z., Baber, U., & Halperin, J. L. (2008) · European Heart Journal Supplements · doi:10.1093/eurheartj/sun029 · Cited by 34

Obstructive sleep apnea may increase the risk of stroke in AF patients: Refining the CHADS2 score

Yazdan-Ashoori, P., & Baranchuk, A. M. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.10.104 · Cited by 34

Adherence to Anticoagulation and Risk of Stroke Among Medicare Beneficiaries Newly Diagnosed with Atrial Fibrillation

Hernandez, I., He, M., Brooks, M. M., Saba, S., & Gellad, W. F. (2019) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-019-00371-3 · Cited by 33

Inositol-1,4,5-Trisphosphate and Ryanodine-Dependent Ca2+ Signaling in a Chronic Dog Model of Atrial Fibrillation

Zhao, Z.-H., Zhang, H.-C., Xu, Y., Zhang, P., Li, X., Liu, Y., & Guo, J. (2006) · Cardiology · doi:10.1159/000095517 · Cited by 31

Atrial-specific drug AVE0118 is free of torsades de pointes in anesthetized dogs with chronic complete atrioventricular block

Oros, A., Volders, P. G. A., Beekman, J. D. M., van der Nagel, T., & Vos, M. A. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.07.017 · Cited by 33

Pharmacoeconomics of anticoagulation therapy for stroke prevention in atrial fibrillation: a review

Szucs, T. D., & Bramkamp, M. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01890.x · Cited by 32

Lack of Complications in Skin Surgery of Patients Receiving Clopidogrel as Compared with Patients Taking Aspirin, Warfarin, and Controls

Kramer, E., Hadad, E., Westreich, M., & Shalom, A. (2010) · The American Surgeon · doi:10.1177/000313481007600103 · Cited by 32

Stroke and Atrial Fibrillation

Extramiana, F., & Maison‐Blanche, P. (2015) · Stroke · doi:10.1161/strokeaha.114.007809 · Cited by 7

Atrial Fibrillation and Mechanisms of Stroke: Time for a New Model

Kamel, H., Okin, P. M., Elkind, M. S. V., & Iadecola, C. (2016) · Stroke · doi:10.1161/strokeaha.115.012004 · Cited by 627

Atrial Fibrillation and the Risk of Stroke

Patel, P. J., & Deo, R. (2015) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.115.003367

Atrial fibrillation and stroke. Revisiting the dilemmas.

Hart, R. G., & Halperin, J. L. (1994) · Stroke · doi:10.1161/01.str.25.7.1337 · Cited by 55

Atrial Fibrillation and Cognition

AnnaPoggesi, DomenicoInzitari, & LeonardoPantoni (2015) · Stroke