The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Effects of Changes in Pa CO 2 Cerebral Blood Volume, Blood Flow, and Vascular Mean Transit Time
Abstract
The relationships between cerebral blood volume (CBV), cerebral blood flow (CBF), and the cerebral vascular mean transit time (t v ) during acute changes in the Pa CO 2 over a range of 15 to 76 torr were investigated in vivo in rhesus monkeys by serially determining the mean transit time of a vascular tracer, 15 O-labeled carboxyhemoglobin, and the mean transit time of a diffusible tracer, 15 O-labeled water. Over this range of Pa CO 2 , a significant linear relationship of CBV = 0.041 Pa CO 2 + 2.0 was found. For each one torr change in Pa CO 2 , there is a change in CBV of 0.041 ml/100 gm of perfused tissue. At a normocarbic value of Pa CO 2 (37 torr), an average value of 3.5 ml/100 gm was found. A nonlinear relationship of CBV and CBF was found. This relationship is expressed in the equation, CBV = 0.80 CBF 0.38 . A significant linear relationship was found between CBF and Pa CO 2 . This was described by the equation, CBF = 1.8 Pa CO 2 - 16.75. For each one torr change in the PaCO 2 , there is a 1.8 ml/100 gm per minute change in the CBF. At a normocarbic value of Pa CO 2 (37 torr), an average value of CBF of 50 ml/100 gm per minute was found. The relationship of CBV and t v was nonlinear and was expressed in the equation, t C15O = 41 CBF -0.62 .
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Kety, S. S., & Schmidt, C. F. (1948) · Journal of Clinical Investigation · doi:10.1172/jci101995 · Cited by 1,827
Cited by
Friston, K. J., Harrison, L., & Penny, W. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00202-7 · Cited by 4,583
Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.
Kwong, K. K., Belliveau, J. W., Chesler, D. A., Goldberg, I. E., Weisskoff, R. M., Poncelet, B. P., Kennedy, D. N., Hoppel, B. E., Cohen, M. S., & Turner, R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5675 · Cited by 4,212
Dynamics of blood flow and oxygenation changes during brain activation: the Balloon model
Buxton, R. B., Wong, E. C., & Frank, L. R. (1998) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910390602 · Cited by 1,665
Wise, R. G., Ide, K., Poulin, M. J., & Tracey, I. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.025 · Cited by 664
Biophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals
Kim, S.-G., & Ogawa, S. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.23 · Cited by 547
Metadata
- Authors
- GRUBB, R. L., RAICHLE, M. E., EICHLING, J. O., & TER-POGOSSIAN, M. M.
- Venue
- Stroke
- Published
- 1974-09
- Volume
- 5
- Issue
- 5
- Pages
- 630-639
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2124913096
- Cited by
- 1,044
- References
- 1
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
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