Cited by 1,665Advanced MRI Techniques and ApplicationsOptical Imaging and Spectroscopy TechniquesFunctional Brain Connectivity Studies

Dynamics of blood flow and oxygenation changes during brain activation: the Balloon model

Buxton, Richard B., Wong, Eric C., Frank, Lawrence R.·1998·Magnetic Resonance in Medicine

Abstract

A biomechanical model is presented for the dynamic changes in deoxyhemoglobin content during brain activation. The model incorporates the conflicting effects of dynamic changes in both blood oxygenation and blood volume. Calculations based on the model show pronounced transients in the deoxyhemoglobin content and the blood oxygenation level dependent (BOLD) signal measured with functional MRI, including initial dips and overshoots and a prolonged poststimulus undershoot of the BOLD signal. Furthermore, these transient effects can occur in the presence of tight coupling of cerebral blood flow and oxygen metabolism throughout the activation period. An initial test of the model against experimental measurements of flow and BOLD changes during a finger-tapping task showed good agreement.

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Crossref · 10.1002/mrm.1910390602

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  • DCM for fMRI rests on a generative model that has two components: a neuronal model describing interactions in a distributed network of neuronal populations, and a component mapping neuronal activity to observed hemodynamic responses.

    “DCM for fMRI rests on a generative model that has two components.”

    From Network discovery with DCM (2011) · cites this paper as Buxton et al., 1998

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Authors
Buxton, R. B., Wong, E. C., & Frank, L. R.
Affiliations
University of California San Diego (US)
Corresponding author
Buxton, Richard B.
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
1998-06
Volume
39
Issue
6
Pages
855-864
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
OpenAlex
W2123586737
Cited by
1,665
References
27
Citations by year
2026: 29 · 2025: 30 · 2024: 41 · 2023: 40 · 2022: 57 · 2021: 58 · 2020: 59 · 2019: 55 · 2018: 68 · 2017: 62 · 2016: 58 · 2015: 93 · 2014: 79 · 2013: 86 · 2012: 91
FWCI
33.54
Type
journal article
Language
en
Open access
closed
Locations
  • Magnetic Resonance in Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
balloon model, brain activation, blood oxygenation, cerebral blood volume, functional MRI, cerebral blood flow, cerebral oxygen consumption, finger tapping task, hemodynamics
MeSH terms
Blood Glucose, Blood Volume, Brain, Deoxyglucose, Dominance, Cerebral, Electroencephalography, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Models, Neurological, Motor Activity, Synaptic Transmission, Oxygen Consumption, Reference Values, Phantoms, Imaging

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