Dynamics of blood flow and oxygenation changes during brain activation: the Balloon model
Abstract
A biomechanical model is presented for the dynamic changes in deoxyhemoglobin content during brain activation. The model incorporates the conflicting effects of dynamic changes in both blood oxygenation and blood volume. Calculations based on the model show pronounced transients in the deoxyhemoglobin content and the blood oxygenation level dependent (BOLD) signal measured with functional MRI, including initial dips and overshoots and a prolonged poststimulus undershoot of the BOLD signal. Furthermore, these transient effects can occur in the presence of tight coupling of cerebral blood flow and oxygen metabolism throughout the activation period. An initial test of the model against experimental measurements of flow and BOLD changes during a finger-tapping task showed good agreement.
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DCM for fMRI rests on a generative model that has two components: a neuronal model describing interactions in a distributed network of neuronal populations, and a component mapping neuronal activity to observed hemodynamic responses.
“DCM for fMRI rests on a generative model that has two components.”
From Network discovery with DCM (2011) · cites this paper as Buxton et al., 1998
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- Authors
- Buxton, R. B., Wong, E. C., & Frank, L. R.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Buxton, Richard B.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 1998-06
- Volume
- 39
- Issue
- 6
- Pages
- 855-864
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2123586737
- Cited by
- 1,665
- References
- 27
- Citations by year
- 2026: 29 · 2025: 30 · 2024: 41 · 2023: 40 · 2022: 57 · 2021: 58 · 2020: 59 · 2019: 55 · 2018: 68 · 2017: 62 · 2016: 58 · 2015: 93 · 2014: 79 · 2013: 86 · 2012: 91
- FWCI
- 33.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Magnetic Resonance in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- balloon model, brain activation, blood oxygenation, cerebral blood volume, functional MRI, cerebral blood flow, cerebral oxygen consumption, finger tapping task, hemodynamics
- MeSH terms
- Blood Glucose, Blood Volume, Brain, Deoxyglucose, Dominance, Cerebral, Electroencephalography, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Models, Neurological, Motor Activity, Synaptic Transmission, Oxygen Consumption, Reference Values, Phantoms, Imaging
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