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Cited by 173Atherosclerosis and Cardiovascular DiseasesNitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Atherosclerosis Is Attenuated by Limiting Superoxide Generation in Both Macrophages and Vessel Wall Cells

Vendrov, Aleksandr E., Hakim, Zeenat S., Madamanchi, Nageswara R., Rojas, Mauricio, Madamanchi, Chaitanya, Runge, Marschall S.·2007·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/atvbaha.107.152629
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Abstract

Objective— We previously showed that NAD(P)H oxidase deficiency significantly reduces atherosclerosis in apoE −/− mice. The present study was designed to determine the relative contribution of monocyte/macrophage versus vascular wall cell NAD(P)H oxidase to atherogenesis in this model. Methods and Results— Cell-specific NAD(P)H oxidase inhibition was achieved via allogenic, sex-mismatched bone marrow transplantation. Aortic atherosclerosis and superoxide production in apoE −/− mice (Control) with functional NAD(P)H oxidase in both monocytes/macrophages and vascular wall cells was compared with that in apoE −/− mice with nonfunctional monocyte/macrophage NAD(P)H oxidase (BMO) or nonfunctional vessel wall NAD(P)H oxidase (VWO). A significant decrease in superoxide production and atherosclerotic lesions was observed in BMO and VWO mice compared with control mice. Interestingly, BMO mice had significantly lower plasma oxidized LDL levels compared with control and VWO mice, whereas aortic sections of VWO mice showed decreased expression of cellular adhesion molecules compared with control and BMO mice. NAD(P)H oxidase deficiency also attenuated neointimal hyperplasia and mitogenic protein activation in apoE −/− mice after arterial injury. Conclusions— We conclude that (1) both monocyte/macrophages and vessel wall cells play critical roles in atherogenesis; (2) decrease in atherosclerosis results from attenuated superoxide generation in monocyte/macrophages or vessel wall cells; and (3) superoxide generation may impact atherosclerosis, in part, by activating smooth muscle cell mitogenic signaling pathways.

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Crossref · 10.1161/atvbaha.107.152629

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Research works printed but not linked: 6

  1. 10.1161/circ.105.3.293 · DOI
  2. 10.1161/res.86.5.494 · DOI
  3. 10.1161/atvb.21.5.739 · DOI
  4. 10.1161/res.84.11.1237 · DOI
  5. 10.1161/atvb.21.10.1577 · DOI
  6. 10.1161/res.86.9.e85 · DOI

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Metadata

Authors
Vendrov, A. E., Hakim, Z. S., Madamanchi, N. R., Rojas, M., Madamanchi, C., & Runge, M. S.
Affiliations
University of North Carolina at Chapel Hill (US)
ORCID
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-12
Volume
27
Issue
12
Pages
2714-2721
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
DOI
10.1161/atvbaha.107.152629
OpenAlex
W2146706268
Cited by
173
References
33
Citations by year
2026: 1 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 12 · 2015: 9 · 2014: 13 · 2013: 13 · 2012: 14
FWCI
3.72
Type
journal article
Language
en
Open access
closed
Locations
  • Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • University of North Carolina at Chapel Hill
  • National Heart, Lung, and Blood Institute (HL-57352, R01HL057352)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
atherosclerosis, NADPH oxidase, superoxide production, monocytes/macrophages, vascular wall cells, bone marrow transplantation, ApoE-deficient mice, oxidized LDL, adhesion molecules, intimal hyperplasia, atherogenesis
MeSH terms
Animals, Aorta, Apolipoproteins E, Dietary Fats, Disease Models, Animal, Endothelium, Vascular, Femoral Artery, Hyperplasia, Lipoproteins, LDL, Macrophages, Muscle, Smooth, Vascular, Oxidation-Reduction, Phosphorylation, RNA, Messenger, Superoxides, Thrombin, Signal Transduction, Cell Adhesion Molecules, Bone Marrow Transplantation, Mice, Knockout, NADPH Oxidases, Mitogen-Activated Protein Kinases, Cell Proliferation, Atherosclerosis, STAT3 Transcription Factor, Mice, Janus Kinase 2

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