Cited by 192Chemokine receptors and signalingAngiogenesis and VEGF in CancerConnective Tissue Growth Factor Research

The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.

Chemokines as Mediators of Neovascularization

Open access
Keeley, Ellen C., Mehrad, Borna, Strieter, Robert M.·2008·Arteriosclerosis, Thrombosis, and Vascular Biology

Abstract

Chemokines are a superfamily of homologous heparin-binding proteins, first described for their role in recruiting leukocytes to sites of inflammation. Chemokines have since been recognized as key factors mediating both physiological and pathological neovascularization in such diverse clinical settings as malignancy, wound repair, chronic fibroproliferative disorders, myocardial ischemia, and atherosclerosis. Members of the CXC chemokine family, structurally defined as containing the ELR amino acid motif, are potent inducers of angiogenesis, whereas another subset of the CXC chemokines inhibits angiogenesis. In addition, CCL2, a CC chemokine ligand, has been implicated in arteriogenesis. In this article, we review the current literature on the role of chemokines as mediators of neovascularization.

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Research works printed but not linked: 7

  1. 10.1161/res.85.3.221 · DOI
  2. 10.1161/res.86.3.286 · DOI
  3. 10.1161/atvb.19.9.2085 · DOI
  4. 10.1172/JCI200524233 · DOI
  5. 10.1161/res.46.4.6244120 · DOI
  6. 10.1161/circ.101.13.1519 · DOI
  7. 10.1161/res.80.6.829 · DOI

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Metadata

Authors
Keeley, E. C., Mehrad, B., & Strieter, R. M.
Affiliations
University of Virginia (US)
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Published
2008-11
Volume
28
Issue
11
Pages
1928-1936
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
OpenAlex
W2125050685
Cited by
192
References
142
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 10 · 2021: 17 · 2020: 7 · 2019: 6 · 2018: 12 · 2017: 7 · 2016: 6 · 2015: 14 · 2014: 12 · 2013: 15 · 2012: 19
FWCI
1.68
Type
journal article
Language
en
Open access
Locations
  • Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL66027, HL-73848, R01HL066027, R01HL073848)
  • National Cancer Institute (CA-87879, R01CA087879)
Topics
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
Keywords
chemokines, neovascularization, angiogenesis, arteriogenesis, CXC chemokines, CC chemokines, MCP-1, inflammation, wound healing, atherosclerosis, myocardial ischemia, fibroproliferative disorders, cancer
MeSH terms
Animals, Humans, Neovascularization, Pathologic, Neovascularization, Physiologic, Chemokines, Angiogenic Proteins, Endothelial Cells, Angiostatic Proteins

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