Do the Apoe −/− and Ldlr −/– Mice Yield the Same Insight on Atherogenesis?

Raise standards for preclinical cancer research

Begley, C. G., & Ellis, L. M. (2012) · Nature · doi:10.1038/483531a · Cited by 2,979 · cited 1×

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237

Subendothelial Lipoprotein Retention as the Initiating Process in Atherosclerosis: Update and Therapeutic Implications

Tabas, I., Williams, K. J., & Borén, J. (2007) · Circulation · doi:10.1161/circulationaha.106.676890 · Cited by 1,399

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

Ishibashi, S., Brown, M. S., Goldstein, J. L., Gerard, R. D., Hammer, R. E., & Herz, J. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116663 · Cited by 1,354

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

Robbins, C. S., Hilgendorf, I., Weber, G. F., Theurl, I., Iwamoto, Y., Figueiredo, J.-L., Gorbatov, R., Sukhova, G. K., Gerhardt, L. M. S., Smyth, D., et al. (2013) · Nature Medicine · doi:10.1038/nm.3258 · Cited by 1,041

Subendothelial retention of atherogenic lipoproteins in early atherosclerosis

Skålén, K., Gustafsson, M., Rydberg, E. K., Hultén, L. M., Wiklund, O., Innerarity, T. L., & Borén, J. (2002) · Nature · doi:10.1038/nature00804 · Cited by 1,019

Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma.

Palinski, W., Hörkkö, S., Miller, E., Steinbrecher, U., Powell, H., Curtiss, L., & Witztum, J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118853 · Cited by 593

ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

Murphy, A. J., Akhtari, M., Tolani, S., Pagler, T., Bijl, N., Kuo, C.-L., Wang, M., Sanson, M., Abramowicz, S., Welch, C., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57559 · Cited by 521

Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice

Praticò, D., Tangirala, R. K., Rader, D. J., Rokach, J., & FitzGerald, G. A. (1998) · Nature Medicine · doi:10.1038/2685 · Cited by 501

Hypercholesterolemia in young adult APOE mice alters epidermal lipid composition and impairs barrier function

Cardoso, R. M., Creemers, E., Absalah, S., Gooris, G. S., Hoekstra, M., Eck, M. V., & Bouwstra, J. A. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.03.008 · Cited by 12

Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations

Karel, M. F. A., Hechler, B., Kuijpers, M. J. E., & Cosemans, J. M. E. M. (2020) · Platelets · doi:10.1080/09537104.2019.1708884 · Cited by 12

Establishment of a Novel Mouse Model for Atherosclerotic Vulnerable Plaque

Wang, X., Fu, Y., Xie, Z., Cao, M., Qu, W., Xi, X., Zhong, S., Piao, M., Peng, X., Jia, Y., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.642751 · Cited by 12

Novel Nongenetic Murine Model of Hyperglycemia and Hyperlipidemia-Associated Aggravated Atherosclerosis

Gaul, S., Shahzad, K., Medert, R., Gadi, I., Maeder, C., Schumacher, D., Wirth, A., Ambreen, S., Fatima, S., Boeckel, J., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.813215 · Cited by 13

The Cholesterol Paradox in Long-Livers from a Sardinia Longevity Hot Spot (Blue Zone)

Errigo, A., Dore, M. P., Portoghese, M., & Pes, G. M. (2025) · Nutrients · doi:10.3390/nu17050765 · Cited by 11

An Atlas of Inter-Organ Metabolite Trafficking in Health and Atherogenic Conditions

Bae, H., Jung, S., Le, J., Tamburini, I. J., Kim, J., Wang, E., Song, W.-S., Choi, W., Jang, K.-H., Kang, T., et al. (2024) · Cell · doi:10.1016/j.cell.2025.05.001 · Cited by 15

Progression of Arterial Vasa Vasorum from Regulator of Arterial Homeostasis to Promoter of Atherogenesis

Burke‐Kleinman, J., & Gotlieb, A. I. (2023) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.06.003 · Cited by 11

Considerations for choosing an optimal animal model of cardiovascular disease

Parikh, M., & Pierce, G. N. (2023) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2023-0206 · Cited by 12

The Effect of Nutritional Ketosis on Aquaporin Expression in Apolipoprotein E-Deficient Mice: Potential Implications for Energy Homeostasis

da Silva, I. V., Gullette, S., Florindo, C., Huang, N. K., Neuberger, T., Ross, A., Soveral, G., & Castro, R. (2022) · Biomedicines · doi:10.3390/biomedicines10051159 · Cited by 10

Insights from Murine Studies on the Site Specificity of Atherosclerosis

Getz, G. S., & Reardon, C. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126375 · Cited by 11

Cardiac Mitochondria Dysfunction in Dyslipidemic Mice

Braczko, A., Kutryb-Zając, B. A., Jędrzejewska, A., Król, O., Mierzejewska, P., Zabielska-Kaczorowska, M. A., Slominska, E. M., & Smolenski, R. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911488 · Cited by 10

Ldlr-Deficient Mice with an Atherosclerosis-Resistant Background Develop Severe Hyperglycemia and Type 2 Diabetes on a Western-Type Diet

Shi, W., Li, J., Bao, K., Chen, M., & Liu, Z. (2022) · Biomedicines · doi:10.3390/biomedicines10061429 · Cited by 9

Experimental models of murine atherosclerosis: does perception match reality?

Johnston, J. M., Francis, S., & Kiss‐Toth, E. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy140 · Cited by 9

Differential RNA expression profiles and competing endogenous RNA-associated regulatory networks during the progression of atherosclerosis

Fu, Y., Sun, C., Li, Q., Qian, F., Li, C., Xi, X., Shang, D., Wang, C., Peng, X., Piao, M., et al. (2021) · Epigenomics · doi:10.2217/epi-2020-0252 · Cited by 9

An Atherogenic Diet Disturbs Aquaporin 5 Expression in Liver and Adipocyte Tissues of Apolipoprotein E-Deficient Mice: New Insights into an Old Model of Experimental Atherosclerosis

da Silva, I. V., Whalen, C. A., Mattie, F. J., Florindo, C., Huang, N. K., Heil, S. G., Neuberger, T., Ross, A. C., Soveral, G., & Castro, R. (2021) · Biomedicines · doi:10.3390/biomedicines9020150 · Cited by 9

Utilizing preclinical models of genetic diversity to improve translation of phytochemical activities from rodents to humans and inform personalized nutrition

Iglesias‐Carres, L., & Neilson, A. P. (2021) · Food & Function · doi:10.1039/d1fo02782d · Cited by 9

Targeting the adaptive immune continuum in atherosclerosis and post-MI injury

Juhász, V., Charlier, F., Zhao, T. X., & Tsiantoulas, D. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.118616 · Cited by 8

Understanding Atherosclerotic Plaque Cellular Composition: Recent Advances Driven by Single Cell Omics

Cetin, E., & Raby, A. (2025) · Cells · doi:10.3390/cells14110770 · Cited by 8

Hyperlipidemia drives tumor growth in a mouse model of obesity-accelerated breast cancer growth

Vieira, R. F. L., Sanchez, S. R., Arumugam, M., Mower, P. D., Curtin, M. C., Jackson, A. E., Gallop, M. R., Wright, J., Bowles, A., Ducker, G. S., et al. (2025) · Cancer & Metabolism · doi:10.1186/s40170-025-00407-0 · Cited by 9

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Marzolla, V., Armani, A., Mammi, C., Feraco, A., & Caprio, M. (2018) · Journal of Visualized Experiments · doi:10.3791/58303 · Cited by 8

Comparison between genetic and pharmaceutical disruption of Ldlr expression for the development of atherosclerosis

Gomes, D. J., Wang, S., Goodspeed, L., Turk, K. E., Wietecha, T., Liu, Y.-J., Bornfeldt, K., O’Brien, K. D., Chait, A., & den Hartigh, L. J. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100174 · Cited by 8

Characterization of Atherosclerotic Mice Reveals a Sex-Dependent Susceptibility to Plaque Calcification but No Major Changes in the Lymphatics in the Arterial Wall

Christ, C., Ocskay, Z., Kovács, G., & Jakus, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074046 · Cited by 7

Mechanisms and consequences of myeloid adhesome dysfunction in atherogenesis

Zhevlakova, I., Liu, H., Dudiki, T., Gao, D., Yakubenko, V. P., Tkachenko, S., Cherepanova, O. A., Podrez, E. A., & Byzova, T. V. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae223 · Cited by 7

ILRUN Promotes Atherosclerosis Through Lipid-Dependent and Lipid-Independent Factors

Bi, X., Stankov, S. G., Lee, P. C., Wang, Z., Wu, X., Li, L., Ko, Y.-A., Cheng, L., Zhang, H., Hand, N. J., et al. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.317156 · Cited by 7

Atherosclerosis Induced by Adeno-Associated Virus Encoding Gain-of-Function PCSK9

Bjørklund, M. M., Bernal, J. A., & Bentzon, J. F. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1924-7_27 · Cited by 7

Animal Models of Atherosclerosis

Getz, G. S., & Reardon, C. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809468-6.00008-5 · Cited by 8

Investigating the Role of Cannabinoid Type 1 Receptors in Vascular Function and Remodeling in a Hypercholesterolemic Mouse Model with Low-Density Lipoprotein–Cannabinoid Type 1 Receptor Double Knockout Animals

Vass, Z., Shenker-Horváth, K., Bányai, B., Vető, K. N., Török, V., Gém, J. B., Nádasy, G. L., Kovács, K. B., Horvath, E. M., Jakus, Z., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179537 · Cited by 6

The ADAM17 Metalloproteinase Maintains Arterial Elasticity

Nicolaou, A., Northoff, B. H., Zhao, Z., Kohlmaier, A., Sass, K., Rose‐John, S., Steffens, S., Weber, C., Teupser, D., & Holdt, L. M. (2018) · Thrombosis and Haemostasis · doi:10.1160/th17-07-0494 · Cited by 6

Formation of atherosclerotic lesions is independent of eosinophils in male mice

Hofheinz, K., Seibert, F., Ackermann, J. A., Dietel, B., Tauchi, M., Oszvar-Kozma, M., Kühn, H., Schett, G. A., Binder, C. J., & Krönke, G. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.08.030 · Cited by 6

Cardiovascular Immunotherapy and the Role of Imaging

Zupančič, E., Fayad, Z. A., & Mulder, W. J. M. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309227 · Cited by 6

Role of Serotonin, Membrane Transporter, and 5-HT2 Receptors in Pathogenesis of Atherosclerotic Plaque Formation in Immature Heterozygous Low-Density Lipoprotein-Receptor-Deficient Mice

Sadykova, D., Nigmatullina, R. R., Salakhova, K. R., Сластникова, Е. С., Galimova, L., Данилевна, Х. Ч., Gafurova, E., & Tsyplakov, D. E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136184 · Cited by 5

The role of interferon regulatory factors in atherosclerosis: from cell type-specific mechanisms to therapeutic strategies

Huang, J., Wang, J., Chen, H. H., Guo, F., & Yuan, X. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1795987 · Cited by 5

Single-cell T-cell landscape in atherosclerosis: implications for targeted therapy and beyond

Luo, R., Liu, S., Ouyang, X., Zhou, E., & Jiang, L. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08334-4 · Cited by 5

Mechanisms of Lipoproteins and Reverse Cholesterol Transport in Atherosclerotic Cardiovascular Disease

Sucharski, H. C., & Koenig, S. N. (2022) · Springer eBooks · doi:10.1007/978-3-031-08309-9_12 · Cited by 6

Haematometabolism rewiring in atherosclerotic cardiovascular disease

Yvan‐Charvet, L., Barouillet, T., & Borowczyk, C. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01108-9 · Cited by 7

Attenuation of Atherosclerosis With PAR4 Deficiency: A Potential Role of Hematopoietically Expressed PAR4 in Atherosclerosis—Brief Report

Wadding-Lee, C., Jay, M., Shearer, S. M., Benson, T. W., Spuzzillo, A. R., Howatt, D. A., Thompson, J. C., Tourdot, B. E., Daugherty, A., Mackman, N., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.322068 · Cited by 5

Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice

Demandt, J. A. F., van Kuijk, K., Theelen, T. L., Marsch, E., Heffron, S. P., Fisher, E. A. A., Carmeliet, P., Biessen, E. A. L., & Sluimer, J. C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.664258 · Cited by 7

Stromal cell-derived factor-1 alpha improves cardiac function in a novel diet-induced coronary atherosclerosis model, the SR-B1ΔCT/LDLR KO mouse

Mullis, D. M., Padilla-Lopez, A., Wang, H., Zhu, Y., Elde, S., Bonham, S. A., Yajima, S., Kocher, O. N., Krieger, M., & Woo, Y.-P. J. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.117518 · Cited by 5

LDL-binding IL-10 reduces vascular inflammation in atherosclerotic mice

Volpatti, L. R., Matos, S. N. D., Borjas, G. J., Beckman, T. N., Reda, J. W., Watkins, E. A., Zhou, Z., Nguyen, M., Solanki, A., Fang, Y., et al. (2026) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01573-8 · Cited by 5

The impact of catechins included in high fat diet on AMP-dependent protein kinase in apoE knock-out mice

Mika, M., Wikiera, A., Antończyk, A., & Grabacka, M. (2020) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2020.1817345 · Cited by 5

Deficiency of circadian gene cryptochromes in bone marrow‐derived cells protects against atherosclerosis in LDLR −/− mice

Lin, Y., Tsai, M., Hsieh, C., Wen, M., & Wang, C. (2021) · The FASEB Journal · doi:10.1096/fj.202001818rrr · Cited by 5

Liver angiocrine factors

Ribatti, D. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102027 · Cited by 5

Spatial Myeloid Landscape of Large Artery Atherosclerotic and Cardioembolic Thrombi Retrieved by Mechanical Thrombectomy

Jo, S., Ok, T., Lee, C. M., Jeong, J. W., Lee, Y. J., Shin, S. J., Fang, S., Lee, K., & Yoon, B. K. (2025) · The FASEB Journal · doi:10.1096/fj.202501658rr · Cited by 4

A Timing Effect of 17-β Estradiol on Atherosclerotic Lesion Development in Female ApoE−/− Mice

Ebenebe, O. V., Ashley, Z., Erickson, J. R., & Heather, A. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134710 · Cited by 4

Carbon Nanodots Attenuate Lipid Peroxidation in the LDL Receptor Knockout Mouse Brain

Erikson, K. M., El‐Khouri, K. G., Petric, R., Tang, C., Chen, J., Vasquez, D. E. C., Fordahl, S. C., & Jia, Z. (2023) · Antioxidants · doi:10.3390/antiox12051081 · Cited by 4

The contribution of prolactin in the occurrence of premature cardiovascular disease predominantly through modulating the inflammatory cascade

Kamperdijk, L., Shkarpa, N., & Twickler, M. (2025) · European Journal of Clinical Investigation · doi:10.1111/eci.70042 · Cited by 4

Recent Highlights of ATVB

Dron, J. S., Lazarte, J., & Hegele, R. A. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311581 · Cited by 4

Effect of diet and genotype on the miRNome of mice with altered lipoprotein metabolism

Busnelli, M., Manzini, S., Colombo, A., Franchi, E., Chiara, M., Zaffaroni, G., Horner, D. S., & Chiesa, G. (2023) · iScience · doi:10.1016/j.isci.2023.107615 · Cited by 4

One Shock, Not One Cure: Electroporation Reveals Disease-Specific Constraints in Hepatocyte Gene Editing Therapy

Clark, C., Pokhrel, M., Arthur, B., Suresh, P., Ates, I., Gibson, J., Dhungana, A., Mehlem, R., Boysia, A., Padalkar, M. V., et al. (2025) · Biology · doi:10.3390/biology14081091 · Cited by 3

The extent of damage to the blood-brain barrier in the hypercholesterolemic LDLR−/−/Apo E−/− double knockout mice depends on the animal's age, duration of pathology and brain area

Czuba, E., Głowiński, S., Wojcik, S. P., Lietzau, G., Zabielska-Kaczorowska, M. A., & Kowiański, P. (2023) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2023.103860 · Cited by 3

Natural and Synthetic LDL-Based Imaging Probes for the Detection of Atherosclerotic Plaques

Fracassi, A., Qiao, H., Lowell, A. N., Cao, J., Bode, J. W., Masai, H., Yoshizawa-Sugata, N., Zhou, R., & Yamakoshi, Y. N. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00667 · Cited by 3

Predilection of Low Protein C-induced Spontaneous Atherothrombosis for the Right Coronary Sinus in Apolipoprotein E deficient mice

Heestermans, M., Ouweneel, A. B., Hassan, J., Kloosterman, M., Reitsma, P. H., Gijbels, M. J., van Vlijmen, B. J. M., & Eck, M. V. (2018) · Scientific Reports · doi:10.1038/s41598-018-32584-y · Cited by 3

Alternate models of acute dyslipidemia reveal divergent pathways upon atherosclerosis initiationPreprint

Hellberg, S., Shavva, V. S., Metso, J., Chen, G., Li, Q., Manfé, V., Olofsson, P. S., Jauhiainen, M., Binder, C. J., & Malin, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.02.279596 · Cited by 3

An Atlas of Inter-Organ Metabolite Trafficking in Health and Atherogenic ConditionsPreprint

Bae, H., Jung, S., Le, J., Tamburini, I. J., Kim, J., Wang, E., Song, W.-S., Jang, K.-H., Kang, T., Lopez, M. L., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4869929 · Cited by 3

TLR5’s Role in Obesity-related Hypertension: Updated Evidence and Prospects

Wu, O., Gao, J., Zhang, X., Liu, W., Zhang, H., Khederzadeh, S., Lu, X., & Wu, Y. (2025) · Angiology · doi:10.1177/00033197251326384 · Cited by 2

Inhibition of ATP citrate lyase does not affect muscle mitochondrial activity in apoE-/- mice

Macchi, C., Fichtner, I., Mohamed, T., Franchi, E., Rizzuto, A. S., Pavanello, C., Gindlhuber, J., Nerini, S., Sirtori, C. R., Osto, E., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118726 · Cited by 2

Accelerated Extracellular Nucleotide Metabolism in Brain Microvascular Endothelial Cells in Experimental Hypercholesterolemia

Czuba, E., Pelikant‐Małecka, I., Lietzau, G., Wojcik, S. P., Smolenski, R. T., & Kowiański, P. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01415-8 · Cited by 2

Exacerbation of atherosclerosis, hyperlipidemia and inflammation by MK886, an inhibitor of leukotriene biosynthesis, in obese and diabetic mice

Keever, K., & Askari, B. (2024) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2024.100203 · Cited by 2

The Heterogeneity and Functional Roles of Dendritic Cells in Atherosclerosis: Origins, Subsets, and Therapeutic Implications

Tianhan, L., Qiu, J., Diedie, L., Lu, L., Lichen, Z., & Liang, Y. (2025) · Immune discovery. · doi:10.70322/immune.2025.10014 · Cited by 2

Activities of purine converting enzymes in heart, liver and kidney mice LDLR−/− and Apo E−/−

Rybakowska, I., Kutryb-Zając, B. A., Milczarek, R., Łukasz, B., Slominska, E. M., & Smolenski, R. T. (2018) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2018.1460482 · Cited by 2

LDR-adapted liver-derived cytokines have potential to induce atherosclerosis

Shin, E., Kim, D., Choi, Y. Y., Youn, H., Seong, K. M., & Youn, B. (2022) · International Journal of Radiation Biology · doi:10.1080/09553002.2023.2145028 · Cited by 2

Expression and Significance of Programmed Death‐1 and Its Ligands in the Accelerated Formation of Atherosclerosis in an Induced Murine Lupus Model

Yang, Y., Chen, Y., Li, Y., Feng, Y., Hu, N., & Xue, L. (2022) · BioMed Research International · doi:10.1155/2022/6255383 · Cited by 1

Hypercholesterolemia Duration and Brain Area Determine Inflammatory Response Intensity and Apoptotic Mediator Activation in Apo E−/−/LDLR−/− Double-Knockout Mice

Czuba, E., Ochocińska, J., Głowiński, S., Braczko, A., Smolenski, R. T., Lietzau, G., & Kowiański, P. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01562-0 · Cited by 1

Effects of Mytilus edulis derived plasmalogens against atherosclerosis via lipid metabolism and MAPK signaling pathway

Feng, J., Zhang, J., Wang, S., Li, Z., Yuan, H., Yao, H., Xue, J., Zheng, J., Wu, Y., Wang, S., et al. (2025) · npj Science of Food · doi:10.1038/s41538-025-00546-0 · Cited by 1

Nitroxoline upregulates low-density lipoprotein receptors expression, enhances lipid metabolism, and reduces hepatic steatosis and atherosclerosis in Apoe−/− mice

Cho, R., Shih, Y., Lien, C., Huang, Y., Lien, P.-Y., Lin, C., Lin, F.-Y., Tsai, C., & Chen, S. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.168016 · Cited by 1

Lipid Metabolism Alterations in Hereditary Inorganic Pyrophosphate Deficiency Syndromes: A Narrative Review of Insights and Controversies

Derudder, R., & Vanakker, O. M. (2025) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.70129 · Cited by 1

Mechanistic Insights into Therapeutic Strategies for Post- Menopausal Atherosclerosis: Evidence from an Ovariectomized Mouse Model

Zulkefli, S. B., Mohamad, F., Nasir, N. A. A., Shuid, A. N., & Azme, N. (2026) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-026-10766-8 · Cited by 1

Context‐Dependent Effects of Apolipoprotein A2 on Lipid Metabolism and Atherogenesis

Zvintzou, E., Fenyo, I. M., Ioniță, R., Kakafoni, G., Dumitrescu, M., Alemi, M., Daraban, B. S., Marinos, K., Gafencu, A. V., & Kypreos, K. E. (2026) · The FASEB Journal · doi:10.1096/fj.202600765r · Cited by 1

Biomimetic L-arginine/selenium nanoplatform with ROS-triggered release alleviates endothelial dysfunction and ferroptosis in atherosclerosis

Sun, J., Li, C., Tong, J., Zhang, R., Yuan, X., Wei, Y., Sun, D., & Guo, X. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.179000 · Cited by 1

Overview of the Most Popular Currently Used Murine Models of Atherosclerosis

Poznyak, A. V., Khotina, V. A., Melnichenko, A. A., Sukhorukov, V. N., Sobenin, I. A., & Orekhov, A. N. (2024) · OnLine Journal of Biological Sciences · doi:10.3844/ojbsci.2024.208.218 · Cited by 1

Development and Characterization of PEG-b-PPS Nanocarriers for Magnetic Resonance Imaging and Drug Delivery

Modak, M. (2021) · doi:10.21985/n2-1mxn-qp96

A novel non-genetic murine model of hyperglycemia and hyperlipidemia-associated aggravated atherosclerosisPreprint

Gaul, S., Shahzad, K., Medert, R., Gadi, I., Maeder, C., Schumacher, D., Wirth, A., Ambreen, S., Fatima, S., Boeckel, J., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.11.468191

Two-Time Scale Control of a High Speed Planar Parallel Manipulator With Structural Flexibility

Kang, B.-S., & Mills, J. K. (2002)

Cigarette Smoke and the NLRP3 Inflammasome

Mehta, S., & Dhawan, V. (2022) · Springer eBooks · doi:10.1007/978-3-030-67928-6_35-1

Exacerbation of Atherosclerosis, Hyperlipidemia and Inflammation by MK-886 in Obese and Diabetic MicePreprint

Keever, K., & Askari, B. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4126767

Cigarette Smoke and the NLRP3 Inflammasome

Mehta, S., & Dhawan, V. (2022) · Springer eBooks · doi:10.1007/978-3-030-92392-1_35

A very-low carbohydrate content in a high-fat diet modifies the plasma metabolome and alleviates experimental atherosclerosisPreprint

Castro, R., Kalecký, K., Huang, N., Petersen, K. S., Singh, V., Ross, A., Neuberger, T., & Bottiglieri, T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.07.527515

Transglutaminases in cardiovascular health and disease

Santhanam, L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19168-8.00001-8

Attenuation of Atherosclerosis with PAR4 Deficiency: Differential Platelet Outcomes in apoE -/- vs. Ldlr -/- MicePreprint

Wadding-Lee, C., Jay, M., Jones, S. M., Thompson, J. C., Howatt, D. A., Daugherty, A., Mackman, N., & Owens, A. P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.01.606266

A newly developed model of atherosclerosis caused by the stress of metabolic syndrome in apolipoprotein E knockout mousePreprint

Tsudome, R., Suematsu, Y., Tashiro, K., Morita, H., Ideishi, A., & Miura, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.24.645136

Nanoparticle-enabled plasma proteomics of a mouse atherosclerosis modelPreprint

Delwarde, C., Matamalas, J. T., Chelvanambi, S., Kasai, T., Shlayen, G., Pestana, D. V. S., Zamani, M., Aikawa, E. R., Aikawa, M., & Singh, S. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.01.667173

The effects of CB1 receptors on angiotensin II–induced vasoconstriction of the aorta in CB1-LDL receptor double knockout animal models with diet-induced atherosclerosis

Shenker-Horváth, K., Szénási, A., Vass, Z., Gém, J. B., Nádasy, G. L., Szekeres, M., & Dörnyei, G. (2025) · Developments in Health Sciences · doi:10.1556/2066.2025.00090

Additional file 1 of Multi-omic signatures of atherogenic dyslipidaemia: pre-clinical target identification and validation in humans

Olkowicz, M., Czyżyńska-Cichoń, I., Szupryczyńska, N., Kostogrys, R. B., Kochan, Z., Dȩbski, J., Dadlez, M., Chłopicki, S., & Smolenski, R. T. (2021) · Figshare · doi:10.6084/m9.figshare.13531904

Metformin does not attenuate angiotensin II-induced aortic aneurysms in low-density lipoprotein receptor deficient mice

Tyagi, S. C., Ito, S., Hubbuch, J., Franklin, M., Howatt, D. A., Lu, H. S., Daugherty, A., & Sawada, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-33367-y

Vascular Contractile and Structural Properties in Diet-Induced Atherosclerosis-Prone CB1-LDL Receptor Double Knockout Animal Model

Shenker-Horváth, K., Vass, Z., Bányai, B., Kiss, S. T., Kovács, K. B., Kiss, J., Trenka, A. P., Gém, J. B., Szénási, A., Horváth, E. M., et al. (2026) · Biomedicines · doi:10.3390/biomedicines14020284

Porphyromonas gingivalis Infection Promotes the Expression of Inflammatory Biomarkers in Atherosclerosis and Periodontitis: An Experimental Study Using an Apolipoprotein E-Deficient Mouse ModelPreprint

Yan, X., Hao, H., Liu, Y., Lou, C., Liu, H., Sun, T., & Luan, Q. (2026) · Research Square · doi:10.21203/rs.3.rs-8027592/v1

Rôle de l’Aryl Hydrocarbon Receptor dans la thrombose durant la maladie rénale chronique

Makhloufi, C. (2019) · theses.fr (ABES) · doi:10.70675/51bdfe17z982ez4141z9db1za781899b9fc0

Advancing atherosclerosis research: mouse models as tools for translational applications

Yang, Z., & She, Z.-G. (2026) · Vessel Plus · doi:10.20517/2574-1209.2025.134

uPAR-Guided Dendrimer Gel Nanoparticles Reprogram Inflammation to Stabilize Atherosclerotic Plaques

Chuang, H.-Y., Kou, H., Huang, Y., & Yang, H. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c26233

Hypoxia-Inducible Factor Prolyl Hydroxylase EGLN3 Stabilizes Atherosclerotic Plaques in ApoE −/− Mice Independently of Its Catalytic Activity

Jin, Y. H., Xu, L., Xiong, Y., Sun, D., Liu, L., Lu, X., Yuan, Y., Yang, N., Ren, Z., Lu, D., et al. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.323765

The ApoE-Null Golden Hamster: A Novel Model of Atherosclerosis

Fang, G., Zheng, S., Miao, J., Zeng, Y., Peng, Y., Zhai, Y., Guo, H., Wang, J., Dong, Y., Tian, X., et al. (2026) · Cardiovascular Toxicology · doi:10.1007/s12012-026-10164-1

Mouse Models of Atherosclerosis: What They Teach Us, What They Miss, and When to Use Them

Geng, X., McKee, A. R., Rosa‐Garrido, M., & Cobo, I. (2026) · Bioengineering · doi:10.3390/bioengineering13080911

Nanoparticle-Enabled Plasma Proteomics of Experimental Atherosclerosis in Mice

Delwarde, C., Matamalas, J. T., Chelvanambi, S., Kasai, T., Shlayen, G., Pestana, D. V. S., Zamani, M., Aikawa, E. R., Aikawa, M., & Singh, S. A. (2026) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2026.101649

Dendritic Cells in the Immunoregulation of Myocardial Infarction: Mechanisms and Therapeutic Strategies

Jiang, C., Ma, Y., Deng, S., Wan, D., & Zhou, P. (2026) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-026-07955-7

A guide to cell-type-specific Cre mouse models in atherosclerosis: from background strains to future directions

Li, T., Dong, X., Niu, X., Zhang, H., Wu, J., Lu, L., Liang, Y., & Zhang, L. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1905454

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Hou, L., Liu, X., Hu, W., Liu, X., & Zhu, W. (2026) · Animal Models and Experimental Medicine · doi:10.1002/ame2.70294

The MASLD–Heart Axis: Biological Mechanisms, Cardiac Remodeling, and Clinical Implications

Oikonomou, E. K., Machairas, N. P., Theofilis, P., Louka, A. M., Xenou, M., Stampouloglou, P. K., Κατσαρού, Ο., Kokkinos, N. K., Lysandrou, A., Karamesinis-Spinthakis, S., et al. (2026) · Pharmaceuticals · doi:10.3390/ph19101629

NSG Mice Lacking Apoe : An Immunodeficient Mouse Model of Atherosclerosis

Megathlin, H. R., Burzenski, L. M., Coleman, D. A., Albert, B., Farley, M. L., Brehm, M. A., Greiner, D. L., & Shultz, L. D. (2026) · The FASEB Journal · doi:10.1096/fj.202603399r

Comparative Studies of Atherosclerosis by Using Genetically Engineered Murine Models

Ishibashi, S., Shimada, M., Chen, Z., Yagyu, H., Osuga, J.-I., Harada, K., Inaba, T., Ohashi, K., Yamada, N., & Yazaki, Y. (1997) · The Journal of Japan Atherosclerosis Society · doi:10.5551/jat1973.24.9_477

Atherogenesis in Apoe−/− and Ldlr−/− Mice with a Genetically Resistant Background

Torikai, H., Chen, M., Jin, L., He, J., Angle, J. F., & Shi, W. (2023) · Cells · doi:10.3390/cells12091255 · Cited by 13

Lipoprotein Size and Atherosclerosis Susceptibility in Apoe −/− and Ldlr −/− Mice

Véniant, M. M., Withycombe, S. K., & Young, S. G. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1001.097780 · Cited by 149

Distinct Sex-Specific Characteristics of Apoe Deficient and Ldlr Deficient Mice in Atherosclerosis: Implications for Model Selection and Therapy Development

Zhao, Y., Wang, L., Berk, B. C., Strijdom, H., Huang, Y., Weng, J., & Xu, S. (2026) · International Journal of Drug Discovery and Pharmacology · doi:10.53941/ijddp.2026.100017

Genetic Modifiers of Atherosclerosis in Mice

Knowles, J. W., & Maeda, N. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.11.2336 · Cited by 176