Cited by 198Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

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Do the Apoe −/− and Ldlr −/– Mice Yield the Same Insight on Atherogenesis?

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Getz, Godfrey S., Reardon, Catherine A.·2016·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/atvbaha.116.306874PMC PMC5001905

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Abstract

Murine models of atherosclerosis are useful for investigating the environmental and genetic influences on lesion formation and composition. Apoe −/− and Ldlr −/− mice are the 2 most extensively used models. The models differ in important ways with respect to the precise mechanism by which their absence enhances atherosclerosis, including differences in plasma lipoproteins. The majority of the gene function studies have utilized only 1 model, with the results being generalized to atherogenic mechanisms. In only a relatively few cases have studies been conducted in both atherogenic murine models. This review will discuss important differences between the 2 atherogenic models and will point out studies that have been performed in the 2 models where results are comparable and those where different results were obtained.

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Authors: Getz, G. S., & Reardon, C. A.
Affiliations: University of Chicago (US)
ORCID: Getz, Godfrey S.
Reardon, Catherine A.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2016-09
Volume: 36
Issue: 9
Pages: 1734-1741
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/atvbaha.116.306874
PMC: PMC5001905
OpenAlex: W2471737803
Cited by: 198
References: 76
Citations by year: 2026: 19 · 2025: 24 · 2024: 20 · 2023: 18 · 2022: 21 · 2021: 19 · 2020: 28 · 2019: 12 · 2018: 19 · 2017: 15 · 2016: 2
FWCI: 9.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL131028, R01HL088420)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords: atherosclerosis, ApoE-deficient mice, Ldlr knockout mice, atherogenesis, serum lipoproteins, genetic susceptibility to atherosclerosis, model comparison
MeSH terms: Animals, Apolipoproteins E, Arteries, Coronary Artery Disease, Disease Models, Animal, Gene Expression Regulation, Lipoproteins, Lymphocytes, Macrophages, Phenotype, Receptors, LDL, Biomarkers, Mice, Knockout, Genetic Predisposition to Disease, Atherosclerosis, Plaque, Atherosclerotic, Diet, High-Fat

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Do the Apoe −/− and Ldlr −/– Mice Yield the Same Insight on Atherogenesis?

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