Cited by 260Telomeres, Telomerase, and SenescenceProtease and Inhibitor MechanismsBlood Coagulation and Thrombosis Mechanisms

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Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence

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Vaughan, Douglas E., Rai, Rahul, Khan, Sadiya S., Eren, Mesut, Ghosh, Asish K.·2017·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/atvbaha.117.309451PMC PMC5846199

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Abstract

PAI-1 (plasminogen activator inhibitor-1) is a member of the evolutionarily conserved serine protease inhibitor family and a potent and rapid-acting inhibitor of both of the mammalian plasminogen activators. Organismal homeostasis requires physiological levels of endogenous PAI-1, and increased PAI-1 production guides the onset and progression of numerous human diseases and contributes to the multimorbidity of aging. Both chronological and stress-induced accelerated aging are associated with cellular senescence and accompanied by marked increases in PAI-1 expression in tissues. Recent studies suggest that PAI-1 is not only a marker but also a key mediator of cellular senescence and organismal aging. Here, we review the significance of PAI-1 as a bonafide marker, as well as a critical mediator, of cellular senescence associated with aging and aging-related pathologies.

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Additional file 3 of Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation
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Additional file 7 of Aberrant methylation of Serpine1 mediates lung injury in neonatal mice prenatally exposed to intrauterine inflammation
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Authors: Vaughan, D. E., Rai, R., Khan, S. S., Eren, M., & Ghosh, A. K.
Affiliations: Northwestern University (US)
ORCID: Vaughan, Douglas E.
Khan, Sadiya S.
Eren, Mesut
Ghosh, Asish K.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2017-08
Volume: 37
Issue: 8
Pages: 1446-1452
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/atvbaha.117.309451
PMC: PMC5846199
OpenAlex: W2621285299
Cited by: 258
References: 52
Citations by year: 2026: 33 · 2025: 27 · 2024: 35 · 2023: 27 · 2022: 34 · 2021: 34 · 2020: 29 · 2019: 24 · 2018: 14
FWCI: 2.25
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (1p01hl108795-01)
National Heart, Lung, and Blood Institute (P01-HL-108795, R01HL051387, F32HL129695)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Keywords: plasminogen activator inhibitor-1, cellular senescence, aging, accelerated aging, serine protease inhibitors, plasminogen activator, biomarkers, multimorbidity
MeSH terms: Aging, Animals, Disease, Health Status, Humans, Signal Transduction, Biomarkers, Cellular Senescence, Plasminogen Activator Inhibitor 1

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Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence

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