Cited by 260Telomeres, Telomerase, and SenescenceProtease and Inhibitor MechanismsBlood Coagulation and Thrombosis Mechanisms

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence

Open access

Vaughan, Douglas E., Rai, Rahul, Khan, Sadiya S., Eren, Mesut, Ghosh, Asish K.·2017·Arteriosclerosis, Thrombosis, and Vascular Biology

DOI 10.1161/atvbaha.117.309451PMC PMC5846199

Open this paper in CoChat — free account

Abstract

PAI-1 (plasminogen activator inhibitor-1) is a member of the evolutionarily conserved serine protease inhibitor family and a potent and rapid-acting inhibitor of both of the mammalian plasminogen activators. Organismal homeostasis requires physiological levels of endogenous PAI-1, and increased PAI-1 production guides the onset and progression of numerous human diseases and contributes to the multimorbidity of aging. Both chronological and stress-induced accelerated aging are associated with cellular senescence and accompanied by marked increases in PAI-1 expression in tissues. Recent studies suggest that PAI-1 is not only a marker but also a key mediator of cellular senescence and organismal aging. Here, we review the significance of PAI-1 as a bonafide marker, as well as a critical mediator, of cellular senescence associated with aging and aging-related pathologies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/atvbaha.117.309451

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cellular senescence: from physiology to pathology
Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3823 · Cited by 2,818
PAI‐1 in tissue fibrosis
Ghosh, A. K., & Vaughan, D. E. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22783 · Cited by 701
Self-citation
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
Kortlever, R. M., Higgins, P. J., & Bernards, R. (2006) · Nature Cell Biology · doi:10.1038/ncb1448 · Cited by 637 · cited 1×
“ing for the first time that PAI-1 is a marker and mediator of replicative senescence.(38) The authors concluded that regulation”
Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene.
Eitzman, D. T., McCoy, R. D., Zheng, X., Fay, W. P., Shen, T., Ginsburg, D., & Simon, R. H. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118396 · Cited by 560
Fibrin Clot Structure and Function
Undas, A., & Ariëns, R. A. S. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.230631 · Cited by 549
Sirt1 modulates premature senescence-like phenotype in human endothelial cells
Ota, H., Akishita, M., Eto, M., Iijima, K., Kaneki, M., & Ouchi, Y. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.08.008 · Cited by 429
Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.
Loskutoff, D. J., van MOURIK, J. A., Erickson, L. A., & Lawrence, D. A. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.10.2956 · Cited by 399
cDNA cloning of human plasminogen activator-inhibitor from endothelial cells.
Ginsburg, D., Zeheb, R., Yang, A. Y., Rafferty, U. M., Andreasen, P. A., Nielsen, L., Danø, K., Lebo, R. V., & GELEHRTER, T. D. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112761 · Cited by 346
Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.
Carmeliet, P., Kieckens, L., Schoonjans, L., Neugeboren, B. I., Nuffelen, A. V., Prendergast, G. C., Cole, M. D., Bronson, R. T., Collen, D., & Mulligan, R. C. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116892 · Cited by 345
Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior
Pawlak, R., Magariños, A. M., Melchor, J. P., McEwen, B. S., & Strickland, S. (2003) · Nature Neuroscience · doi:10.1038/nn998 · Cited by 305

Show all 52 references

Sorted by citations

Health benefits of resveratrol: Evidence from clinical studies
Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C. (2019) · Medicinal Research Reviews · doi:10.1002/med.21565 · Cited by 523
TGF-β Signaling in Cellular Senescence and Aging-Related Pathology
Tominaga, K., & Suzuki, H. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205002 · Cited by 393
Aging, Cellular Senescence, and Alzheimer’s Disease
Liu, R.-M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041989 · Cited by 267
Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19
D’Agnillo, F., Walters, K.-A., Xiao, Y., Sheng, Z.-M., Scherler, K., Park, J., Gygli, S., Rosas, L. A., Sadtler, K., Kalish, H., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7790 · Cited by 237
A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?
Sillen, M., & Declerck, P. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052721 · Cited by 251
Thrombotic Regulation From the Endothelial Cell Perspectives
Wang, M., Hao, H., Leeper, N. J., & Zhu, L. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.310367 · Cited by 195
Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction
Pandey, A., Shah, S. J., Butler, J., Kellogg, D. L., Lewis, G. D., Forman, D. E., Mentz, R. J., Borlaug, B. A., Simon, M. A., Chirinos, J. A., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.07.014 · Cited by 184
Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells
Gustafson, B., Nerstedt, A., & Smith, U. (2019) · Nature Communications · doi:10.1038/s41467-019-10688-x · Cited by 191
Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart
Vidal, R. O., Wagner, J. U. G., Braeuning, C., Fischer, C., Patrick, R., Tombor, L., Muhly-Reinholz, M., John, D., Kliem, M., Conrad, T., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.131092 · Cited by 168
Targeting PAI-1 in Cardiovascular Disease: Structural Insights Into PAI-1 Functionality and Inhibition
Sillen, M., & Declerck, P. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.622473 · Cited by 164
PAI-1 Regulation of TGF-β1–induced Alveolar Type II Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages
Rana, T., Jiang, C., Liu, G., Miyata, T., Antony, V. B., Thannickal, V. J., & Liu, R.-M. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0071oc · Cited by 161
Copper deficiency may be a leading cause of ischaemic heart disease
DiNicolantonio, J. J., Mangan, D. F., & O’Keefe, J. H. (2018) · Open Heart · doi:10.1136/openhrt-2018-000784 · Cited by 129
A Serpin With a Finger in Many PAIs: PAI-1's Central Function in Thromboinflammation and Cardiovascular Disease
Morrow, G. B., Whyte, C. S., & Mutch, N. J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.653655 · Cited by 121
The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1
Samarakoon, R., Higgins, S. P., Higgins, C. E., & Higgins, P. J. (2019) · Biomolecules · doi:10.3390/biom9080341 · Cited by 104
COVID-19 and Crosstalk With the Hallmarks of Aging
Salimi, S., & Hamlyn, J. M. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa149 · Cited by 97
PAI-1, the Plasminogen System, and Skeletal Muscle
Rahman, F. A., & Krause, M. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197066 · Cited by 88
Patients with systemic lupus erythematosus face a high risk of cardiovascular disease: A systematic review and Meta-analysis
Lü, X., Wang, Y., Zhang, J., Pu, D., Hu, N., Luo, J., An, Q., & He, L. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107466 · Cited by 98
Targets for protection and mitigation of radiation injury
Khodamoradi, E., Hoseini‐Ghahfarokhi, M., Amini, P., Motevaseli, E., Shabeeb, D., Musa, A. E., Najafi, M., & Farhood, B. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03479-x · Cited by 88
Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease
Bryant, A. G., Hu, M., Carlyle, B. C., Arnold, S. E., Frosch, M. P., Das, S., Hyman, B. T., & Bennett, R. E. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.575953 · Cited by 79
Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Varela-Eirín, M., Carpintero-Fernández, P., Guitián‐Caamaño, A., Varela-Vázquez, A., García-Yuste, A., Sánchez‐Temprano, A., Bravo, S. B., Cabanas, J. Y., Fonseca, E., Largo, R., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05089-w · Cited by 87
Stress-induced RNA–chromatin interactions promote endothelial dysfunction
Calandrelli, R., Xu, L., Luo, Y., Wu, W., Fan, X., Nguyen, T. C., Chen, C.-J., Sriram, K., Tang, X., Burns, A. B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18957-w · Cited by 75
Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome
Khoukaz, H. B., Ji, Y., Braet, D. J., Vadali, M., Abdelhamid, A. A., Emal, C. D., Lawrence, D. A., & Fay, W. P. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.313775 · Cited by 69
The uPA/uPAR System Orchestrates the Inflammatory Response, Vascular Homeostasis, and Immune System in Fibrosis Progression
Kanno, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021796 · Cited by 67
The Role of Fibrinolytic Regulators in Vascular Dysfunction of Systemic Sclerosis
Kanno, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030619 · Cited by 62
In vivo analysis of γH2AX+ cells in skeletal muscle from aged and obese humans
Dungan, C. M., Peck, B. D., Walton, R. G., Huang, Z., Bamman, M. M., Kern, P. A., & Peterson, C. A. (2020) · The FASEB Journal · doi:10.1096/fj.202000111rr · Cited by 61
Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities
Sun, X., & Feinberg, M. W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.693067 · Cited by 56
A signaling pathway map of plasminogen activator inhibitor-1 (PAI-1/SERPINE-1): a review of an innovative frontier in molecular aging and cellular senescence
Shaikh, S. B., Balaya, R. D. A., Dagamajalu, S., Bhandary, Y. P., Unwalla, H. J., Prasad, T. S. K., & Rahman, I. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01910-5 · Cited by 60
Inhibition of PAI (Plasminogen Activator Inhibitor)-1 Improves Brain Collateral Perfusion and Injury After Acute Ischemic Stroke in Aged Hypertensive Rats
Chan, S., Bishop, N. M., Li, Z., & Cipolla, M. J. (2018) · Stroke · doi:10.1161/strokeaha.118.022056 · Cited by 55
Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis
Wang, Y., Liu, L., Song, Y., Yu, X., & Deng, H. (2022) · Protein & Cell · doi:10.1007/s13238-021-00894-z · Cited by 50
Sex Differences in Molecular Mechanisms of Cardiovascular Aging
Justina, V. D., Miguez, J. S., Priviero, F. B. M., Sullivan, J. C., Giachini, F. R. C., & Webb, R. C. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.725884 · Cited by 54
Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells
Delfarah, A., Parrish, S., Junge, J. A., Yang, J., Seo, F., Li, S., Mac, J., Wang, P., Fraser, S. E., & Graham, N. A. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005806 · Cited by 50
Aging, obese-insulin resistance, and bone remodeling
Imerb, N., Thonusin, C., Chattipakorn, N., & Chattipakorn, S. C. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111335 · Cited by 54
Impairments of intestinal arginine and NO metabolisms trigger aging-associated intestinal barrier dysfunction and ‘inflammaging'
Brandt, A., Baumann, A., Hernández-Arriaga, A. M., Jung, F., Nier, A., Staltner, R., Rajcic, D., Schmeer, C. W., Witte, O. W., Wessner, B., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102528 · Cited by 51
Characterisation of premature cell senescence in Alzheimer's disease using single nuclear transcriptomics
Fancy, N. N., Smith, A. M., Caramello, A., Tsartsalis, S., Davey, K., Muirhead, R. C. J., McGarry, A., Jenkyns, M. H., Schneegans, E., Chau, V., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02727-9 · Cited by 48
“We found that SERPINE1, a known senescence marker and SASP factor, was co-expressed with these genes in Module-5 [73].”
Background
Mitochondria-targeted esculetin mitigates atherosclerosis in the setting of aging via the modulation of SIRT1-mediated vascular cell senescence and mitochondrial function in Apoe−/− mice
Karnewar, S., Pulipaka, S., Katta, S., Panuganti, D., Neeli, P. K., Thennati, R., Jerald, M. K., & Kotamraju, S. (2022) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2022.07.012 · Cited by 49
PAI-1 contributes to homocysteine-induced cellular senescence
Sun, T., Ghosh, A. K., Eren, M., Miyata, T., & Vaughan, D. E. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109394 · Cited by 49
Self-citation
Serpine1 Knockdown Enhances MMP Activity after Flexor Tendon Injury in Mice: Implications for Adhesions Therapy
Freeberg, M. A. T., Farhat, Y. M., Easa, A., Kallenbach, J. G., Malcolm, D. W., Buckley, M. R., Benoit, D. S. W., & Awad, H. A. (2018) · Scientific Reports · doi:10.1038/s41598-018-24144-1 · Cited by 51
High Phosphate Induces and Klotho Attenuates Kidney Epithelial Senescence and Fibrosis
Maique, J., Flores, B., Shi, M., Shepard, S., Zhou, Z., Yan, S., Moe, O. W., & Hu, M. C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01273 · Cited by 47
Heart Failure with Preserved Ejection Fraction: The Pathophysiological Mechanisms behind the Clinical Phenotypes and the Therapeutic Approach
Stoicescu, L., Crișan, D., Morgovan, C., Avram, L., & Ghibu, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020794 · Cited by 57
Biomarkers Assessing Endothelial Dysfunction in Alzheimer’s Disease
Custodia, A., Aramburu-Núñez, M., Rodríguez‐Arrizabalaga, M., Peleteiro, J. M. P., Vázquez‐Vázquez, L., Camino-Castiñeiras, J., Aldrey, J. M., Castillo, J., Ouro, A., Sobrino, T., et al. (2023) · Cells · doi:10.3390/cells12060962 · Cited by 47
CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB Pathway
Armento, A., Schmidt, T. L., Sonntag, I., Merle, D. A., Jarboui, M. A., Kilger, E., Clark, S. J., & Ueffing, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168727 · Cited by 44
A Scoping Review on Biomarkers of Endothelial Dysfunction in Small Vessel Disease: Molecular Insights from Human Studies
García, D. J., Chagnot, A., Wardlaw, J. M., & Montagne, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713114 · Cited by 47
Coagulation and Fibrinolysis in Obstructive Sleep Apnoea
Bikov, A., Mészáros, M., & Schwarz, E. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062834 · Cited by 41
Synergy between plasminogen activator inhibitor-1, α-synuclein, and neuroinflammation in Parkinson’s disease
Reuland, C. J., & Church, F. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109602 · Cited by 40
Short Sleep and Insomnia Are Associated With Accelerated Epigenetic Age
Kusters, C., Klopack, E. T., Crimmins, E. M., Seeman, T. E., Cole, S. W., & Carroll, J. (2023) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001243 · Cited by 42
Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase
Garcia, V. G., Park, E. J., Siragusa, M., Fröhlich, F., Haque, M. M., Pascale, J. V., Heberlein, K. R., Isakson, B. E., Stuehr, D. J., & Sessa, W. C. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918761117 · Cited by 37
Empagliflozin decreases the plasma concentration of plasminogen activator inhibitor-1 (PAI-1) in patients with type 2 diabetes: Association with improvement of fibrinolysis
Sakurai, S., Jojima, T., Iijima, T., Tomaru, T., Usui, I., & Aso, Y. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107703 · Cited by 39
Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels
Jin, C. J., Baumann, A., Brandt, A., Engstler, A. J., Nier, A., Hege, M., Schmeer, C. W., Kehm, R., Höhn, A., Grune, T., et al. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00345.2018 · Cited by 38
Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling
Watson, C. T., Saaid, H., Vedula, V., Cardenas, J. C., Henke, P. K., Nicoud, F., Xu, X. Y., Hunt, B. J., & Manning, K. B. (2023) · Annals of Biomedical Engineering · doi:10.1007/s10439-023-03390-z · Cited by 41
SARS-CoV-2 induced vascular endothelial dysfunction: direct or indirect effects?
Lui, K. O., Ma, Z., & Dimmeler, S. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad191 · Cited by 40
Chronic irradiation of human cells reduces histone levels and deregulates gene expression
Lowe, D., Herzog, M., Mosler, T., Cohen, H., Felton, S. J., Beli, P., Raj, K., Galanty, Y., & Jackson, S. P. (2020) · Scientific Reports · doi:10.1038/s41598-020-59163-4 · Cited by 40
PAI-1: A Major Player in the Vascular Dysfunction in Obstructive Sleep Apnea?
Badran, M., & Gozal, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105516 · Cited by 38
The Fibrinolytic System: Mysteries and Opportunities
Medcalf, R. L., & Keragala, C. B. (2021) · HemaSphere · doi:10.1097/hs9.0000000000000570 · Cited by 36
Protease Activity in Vascular Disease
Slack, M. A., & Gordon, S. M. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312413 · Cited by 35
Alzheimer’s Amyloid-β Accelerates Human Neuronal Cell Senescence Which Could Be Rescued by Sirtuin-1 and Aspirin
Li, Y., Lü, J., Hou, Y., Huang, S., & Pei, G. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.906270 · Cited by 36
Acetyltransferase p300 Is a Putative Epidrug Target for Amelioration of Cellular Aging-Related Cardiovascular Disease
Ghosh, A. K. (2021) · Cells · doi:10.3390/cells10112839 · Cited by 33
Self-citation
The future of heart failure with preserved ejection fraction
Heinzel, F. R., & Shah, S. J. (2022) · Herz · doi:10.1007/s00059-022-05124-8 · Cited by 36
The Central Role of PAI-1 in COVID-19: Thrombosis and beyond
Khan, S. S. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0208ed · Cited by 33
Self-citation
Senescence-associated microvascular endothelial dysfunction: A focus on the blood-brain and blood-retinal barriers
Kim, S. Y., & Cheon, J. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102446 · Cited by 33
Molecular basis of senescence transmitting in the population of human endometrial stromal cells
Griukova, A., Deryabin, P. I., Shatrova, A. N., Burova, E., Severino, V., Farina, A., Nikolsky, N. N., & Borodkina, A. V. (2019) · Aging · doi:10.18632/aging.102441 · Cited by 32
The protective role of omentin-1 in IL-1β-induced chondrocyte senescence
Chai, B., Zheng, Z., Liao, X., Li, K.-Y., Liang, J.-S., Huang, Y., Tong, C.-J., Ou, D.-J., & Lu, J. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1699803 · Cited by 32
Do inflammaging and coagul-aging play a role as conditions contributing to the co-occurrence of the severe hyper-inflammatory state and deadly coagulopathy during COVID-19 in older people?
Xu, K., Wei, Y., Giunta, S., Zhou, M., & Xia, S. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111423 · Cited by 31
Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows atherogenesis in mice
Caland, L., Labbé, P., Mamarbachi, M., Villeneuve, L. R., Ferbeyre, G., Noly, P., Carrier, M., Thorin‐Trescases, N., & Thorin, É. (2019) · Aging · doi:10.18632/aging.102020 · Cited by 35
20-Hydroxyeicosatetraenoic acid (20-HETE): Bioactions, receptors, vascular function, cardiometabolic disease and beyond
Pascale, J. V., Wolf, A., Kadish, Y., Diegisser, D., Kulaprathazhe, M., Yemane, D., Ali, S., Kim, N., Baruch, D. E., Yahaya, M. A. F., et al. (2023) · Advances in pharmacology · doi:10.1016/bs.apha.2023.01.002 · Cited by 30
Endothelial Senescence and Its Impact on Angiogenesis in Alzheimer’s Disease
Georgieva, I., Tchekalarova, J. D., Iliev, D. B., & Tzoneva, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411344 · Cited by 29
ZMPSTE24 Regulates SARS-CoV-2 Spike Protein–enhanced Expression of Endothelial PAI-1
Han, M., & Pandey, D. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0544oc · Cited by 28
Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework
Clerbaux, L., Albertini, M. C., Amigó, N., Beronius, A., Bezemer, G. F. G., Coecke, S., Daskalopoulos, E. P., del Giudice, G., Greco, D., Grenga, L., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11154464 · Cited by 30
New Insights in Bladder Cancer Diagnosis: Urinary miRNAs and Proteins
Amuran, G. G., Eyüboğlu, İ. P., Tınay, İ., & Akkіprіk, M. (2018) · Medical Sciences · doi:10.3390/medsci6040113 · Cited by 27
Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484
Sillen, M., Miyata, T., Vaughan, D. E., Strelkov, S. V., & Declerck, P. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031482 · Cited by 27
Self-citation
Therapeutic Induction of Collateral Flow
Cipolla, M. J. (2022) · Translational Stroke Research · doi:10.1007/s12975-022-01019-2 · Cited by 27
Cellular Aging Secretes: a Comparison of Bone-Marrow-Derived and Induced Mesenchymal Stem Cells and Their Secretome Over Long-Term Culture
Marote, A., Santos, D. J., Mendes-Pinheiro, B., Serre-Miranda, C., Anjo, S. I., Vieira, J., Ferreira-Antunes, F., Correia, J. S., Borges-Pereira, C., Pinho, A. G., et al. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10453-6 · Cited by 27
Plasminogen Activator Inhibitor‐1 and Diagnosis of the Metabolic Syndrome in a West African Population
Kodaman, N. M., Aldrich, M. C., Sobota, R. S., Asselbergs, F. W., Brown, N. J., Moore, J. H., & Williams, S. M. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003867 · Cited by 26
A new assay for global fibrinolysis capacity (GFC): Investigating a critical system regulating hemostasis and thrombosis and other extravascular functions
Amiral, J., Laroche, M., & Seghatchian, J. (2018) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2018.02.020 · Cited by 26
Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging
Al-Regaiey, K. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00481-w · Cited by 29
The role of the senescence-associated secretory phenotype in cardiovascular disease among the elderly
Sutanto, H., Fetarayani, D., Narendra, M. R., & Nasution, S. A. (2025) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2025.106488 · Cited by 30
Microbiota profiling in aging-associated inflammation and liver degeneration
Baumann, A., Hernández-Arriaga, A. M., Brandt, A., Sánchez, V., Nier, A., Jung, F., Kehm, R., Höhn, A., Grune, T., Frahm, C., et al. (2021) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2021.151500 · Cited by 26
Association between the epigenetic lifespan predictor GrimAge and history of suicide attempt in bipolar disorder
Lima, C. N. D. C., Kovács, E. H. C., Mirza, S. A., Favero-Campbell, A. D., Díaz, A. P., Quevedo, J., Argue, B. M., Richards, J. G., Williams, A. J., Wemmie, J. A., et al. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01557-9 · Cited by 26
Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes
Georget, M., Defois, A., Guiho, R., Bon, N., Allain‐Maillet, S., Boyer, C., Halgand, B., Waast, D., Grimandi, G., Fouasson‐Chailloux, A., et al. (2023) · Aging · doi:10.18632/aging.204881 · Cited by 25
Epigenetic clock analysis and increased plasminogen activator inhibitor-1 in high-functioning autism spectrum disorder
Okazaki, S., Kimura, R., Otsuka, I., Funabiki, Y., Murai, T., & Hishimoto, A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263478 · Cited by 23
Histone H2A Ubiquitination Resulting From Brap Loss of Function Connects Multiple Aging Hallmarks and Accelerates Neurodegeneration
Guo, Y., Chomiak, A. A., Hong, Y., Lowe, C. C., Kopsidas, C. A., Chan, W., Andrade, J., Pan, H., Zhou, X., Monuki, E. S., et al. (2021) · iScience · doi:10.1016/j.isci.2022.104519 · Cited by 24
Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis
Fournier, F., Diaz-Marin, R., Pilon, F., Neault, M., Juneau, R., Girouard, G., Wilson, A. M., Larrivée, B., Mallette, F. A., Crespo‐Garcia, S., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2209973120 · Cited by 23
Impaired autophagy-accelerated senescence of alveolar type II epithelial cells drives pulmonary fibrosis induced by single-walled carbon nanotubes
Zhang, X., Hu, X., Zhang, Y., Liu, B., Pan, H., Liu, Z., Yao, Z., Zhu, Q., Wu, C., & Shen, T. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01821-6 · Cited by 23
Acetylshikonin from Zicao ameliorates renal dysfunction and fibrosis in diabetic mice by inhibiting TGF-β1/Smad pathway
Li, Z., Hong, Z., Peng, Z., Zhao, Y., & Shao, R. (2018) · Human Cell · doi:10.1007/s13577-017-0192-8 · Cited by 23
The Role of Clock Genes in Fibrinolysis Regulation: Circadian Disturbance and Its Effect on Fibrinolytic Activity
Carmona, P., Méndez, N., Ili, C., & Brebi, P. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00129 · Cited by 24
Senescence-Associated Secretory Phenotype Determines Survival and Therapeutic Response in Cervical Cancer
Purohit, S. B., Zhi, W., Ferris, D. G., Alverez, M., Tran, L. K. H., Tran, P. M. H., Dun, B., Hopkins, D., dos Santos, B., Ghamande, S. A., et al. (2020) · Cancers · doi:10.3390/cancers12102899 · Cited by 22
Apremilast prevents IL‑17‑induced cellular senescence in ATDC5 chondrocytes mediated by SIRT1
Wang, B., Sun, W., Bi, K., Li, Y., & Li, F. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4845 · Cited by 25
SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson–Gilford progeria syndrome
Catarinella, G., Nicoletti, C., Bracaglia, A., Procopio, P., Salvatori, I., Taggi, M., Valle, C., Ferri, A., Canipari, R., Puri, P., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05168-y · Cited by 23
PAI-1: A New Target for Controlling Lung-Cell Senescence and Fibrosis?
Adnot, S., Breau, M., & Houssaini, A. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0341ed · Cited by 25
Comparative gene array analyses of severe elastic fiber defects in late embryonic and newborn mouse aorta
Staiculescu, M. C., Cocciolone, A. J., Procknow, J. D., Kim, J., & Wagenseil, J. E. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00080.2018 · Cited by 20
Adults with Down syndrome challenge another paradigm: When aging no longer entails arterial hypertension
Roy‐Vallejo, E., Galván‐Román, J. M., Moldenhauer, F., & de Asúa, D. R. (2020) · Journal of Clinical Hypertension · doi:10.1111/jch.13930 · Cited by 21
Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM2.5
Ghosh, A. K., Soberanes, S., Lux, E., Shang, M., Aillon, R. P., Eren, M., Budinger, G. R. S., Miyata, T., & Vaughan, D. E. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117283 · Cited by 21
Self-citation
C2-Ceramide-Induced Rb-Dominant Senescence-Like Phenotype Leads to Human Breast Cancer MCF-7 Escape from p53-Dependent Cell Death
Chang, W., Wu, C., Lin, Y.-C., Wu, M., Su, K.-L., Yuan, S. F., Wang, H.-M. D., Fong, Y., Lin, Y., & Chiu, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174292 · Cited by 20
Review of evidence implicating the plasminogen activator system in blood-brain barrier dysfunction associated with Alzheimer’s disease
Tang, M.-Y., Gorin, F. A., & Lein, P. J. (2022) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2022.05 · Cited by 20
Ketosis Suppression and Ageing (KetoSAge): The Effects of Suppressing Ketosis in Long Term Keto-Adapted Non-Athletic Females
Cooper, I. D., Kyriakidou, Y., Edwards, K., Petagine, L., Seyfried, T. N., Duraj, T., Soto-Mota, A., Scarborough, A., Jacome, S. L., Brookler, K. H., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115621 · Cited by 20
PAI-1 Deficiency Promotes NET-mediated Pyroptosis and Ferroptosis during Pseudomonas Aeruginosa-induced Acute Lung Injury by Regulating the PI3K/MAPK/AKT Axis
Aji, N., Wang, L., Wang, S., Pan, T., Song, J., Chen, C., Wang, L., Feng, N., Tang, X., & Song, Y. (2024) · Inflammation · doi:10.1007/s10753-024-02102-6 · Cited by 20
The Roles of Fibrinolytic Factors in Bone Destruction Caused by Inflammation
Kanno, Y. (2024) · Cells · doi:10.3390/cells13060516 · Cited by 19
Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omics
Venkataraman, A., Kordic, I., Li, J., Zhang, N. Y., Bharadwaj, N. S., Fang, Z., Das, S., & Coskun, A. F. (2024) · npj Aging · doi:10.1038/s41514-024-00178-w · Cited by 21
GPR120 Agonist GW9508 Ameliorated Cellular Senescence Induced by ox-LDL
Liu, R., Cheng, F., Zeng, K., Li, W., & Lan, J. (2020) · ACS Omega · doi:10.1021/acsomega.0c03581 · Cited by 19
Genistein Suppresses Ox-LDL-elicited Oxidative Stress and Senescence in HUVECs through the SIRT1-p66shc-Foxo3a Pathways
Zhang, H., Pang, X., Yu, H., & Zhou, H. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22939 · Cited by 18
Molecular mechanism of two nanobodies that inhibit PAI‐1 activity reveals a modulation at distinct stages of the PAI‐1/plasminogen activator interaction
Sillen, M., Weeks, S. D., Zhou, X., Komissarov, A. A., Florova, G., Idell, S., Strelkov, S. V., & Declerck, P. J. (2019) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14716 · Cited by 18

Authors: Vaughan, D. E., Rai, R., Khan, S. S., Eren, M., & Ghosh, A. K.
Affiliations: Northwestern University (US)
ORCID: Vaughan, Douglas E.
Khan, Sadiya S.
Eren, Mesut
Ghosh, Asish K.
Venue: Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2017-08
Volume: 37
Issue: 8
Pages: 1446-1452
ISSN: 1079-5642 (ISSN-L)
1524-4636
DOI: 10.1161/atvbaha.117.309451
PMC: PMC5846199
OpenAlex: W2621285299
Cited by: 258
References: 52
Citations by year: 2026: 33 · 2025: 27 · 2024: 35 · 2023: 27 · 2022: 34 · 2021: 34 · 2020: 29 · 2019: 24 · 2018: 14
FWCI: 2.25
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (1p01hl108795-01)
National Heart, Lung, and Blood Institute (P01-HL-108795, R01HL051387, F32HL129695)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Keywords: plasminogen activator inhibitor-1, cellular senescence, aging, accelerated aging, serine protease inhibitors, plasminogen activator, biomarkers, multimorbidity
MeSH terms: Aging, Animals, Disease, Health Status, Humans, Signal Transduction, Biomarkers, Cellular Senescence, Plasminogen Activator Inhibitor 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks