The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Plasminogen Activator Inhibitor-1 Is a Marker and a Mediator of Senescence
Open accessAbstract
PAI-1 (plasminogen activator inhibitor-1) is a member of the evolutionarily conserved serine protease inhibitor family and a potent and rapid-acting inhibitor of both of the mammalian plasminogen activators. Organismal homeostasis requires physiological levels of endogenous PAI-1, and increased PAI-1 production guides the onset and progression of numerous human diseases and contributes to the multimorbidity of aging. Both chronological and stress-induced accelerated aging are associated with cellular senescence and accompanied by marked increases in PAI-1 expression in tissues. Recent studies suggest that PAI-1 is not only a marker but also a key mediator of cellular senescence and organismal aging. Here, we review the significance of PAI-1 as a bonafide marker, as well as a critical mediator, of cellular senescence associated with aging and aging-related pathologies.
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In the citing paper
“SERPINE1 by itself is a marker of PS hepatocytes and is a known mediator of senescence.45”
From Cellular senescence in human liver under normal aging and cancer (2026) · cites this paper as [45]
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“We found that SERPINE1, a known senescence marker and SASP factor, was co-expressed with these genes in Module-5 [73].”
From Characterisation of premature cell senescence in Alzheimer's disease using single nuclear transcriptomics (2024) · cites this paper as [73]
In the citing paper
“SASP markers were elevated at the protein and gene levels in lung tissue from our COVID-19 autopsy case series, including PAI-1, which is considered both a major marker and mediator of cellular senescence (65).”
From Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19 (2021) · cites this paper as [65]
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Citations
Cites
Cellular senescence: from physiology to pathology
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Self-citationKortlever, R. M., Higgins, P. J., & Bernards, R. (2006) · Nature Cell Biology · doi:10.1038/ncb1448 · Cited by 637 · cited 1×
“ing for the first time that PAI-1 is a marker and mediator of replicative senescence.(38) The authors concluded that regulation”
Eitzman, D. T., McCoy, R. D., Zheng, X., Fay, W. P., Shen, T., Ginsburg, D., & Simon, R. H. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118396 · Cited by 560
Fibrin Clot Structure and Function
Undas, A., & Ariëns, R. A. S. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.230631 · Cited by 549
Sirt1 modulates premature senescence-like phenotype in human endothelial cells
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cDNA cloning of human plasminogen activator-inhibitor from endothelial cells.
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Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior
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Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C. (2019) · Medicinal Research Reviews · doi:10.1002/med.21565 · Cited by 523
TGF-β Signaling in Cellular Senescence and Aging-Related Pathology
Tominaga, K., & Suzuki, H. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205002 · Cited by 393
Aging, Cellular Senescence, and Alzheimer’s Disease
Liu, R.-M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041989 · Cited by 267
D’Agnillo, F., Walters, K.-A., Xiao, Y., Sheng, Z.-M., Scherler, K., Park, J., Gygli, S., Rosas, L. A., Sadtler, K., Kalish, H., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7790 · Cited by 237
Sillen, M., & Declerck, P. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052721 · Cited by 251
Metadata
- Authors
- Vaughan, D. E., Rai, R., Khan, S. S., Eren, M., & Ghosh, A. K.
- Affiliations
- Northwestern University (US)
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2017-08
- Volume
- 37
- Issue
- 8
- Pages
- 1446-1452
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- PMC
- PMC5846199
- OpenAlex
- W2621285299
- Cited by
- 258
- References
- 52
- Citations by year
- 2026: 33 · 2025: 27 · 2024: 35 · 2023: 27 · 2022: 34 · 2021: 34 · 2020: 29 · 2019: 24 · 2018: 14
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1p01hl108795-01)
- National Heart, Lung, and Blood Institute (P01-HL-108795, R01HL051387, F32HL129695)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- plasminogen activator inhibitor-1, cellular senescence, aging, accelerated aging, serine protease inhibitors, plasminogen activator, biomarkers, multimorbidity
- MeSH terms
- Aging, Animals, Disease, Health Status, Humans, Signal Transduction, Biomarkers, Cellular Senescence, Plasminogen Activator Inhibitor 1
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