The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Omega-3 Fatty Acid Supplementation Does Not Reduce Risk of Atrial Fibrillation After Coronary Artery Bypass Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Abstract
Background— Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been reported to reduce the risk of sudden cardiac death presumed to be due to fatal ventricular arrhythmias, but their effect on atrial arrhythmias is unclear. Methods and Results— Patients (n=108) undergoing coronary artery bypass graft surgery were randomly assigned to receive 2 g/d n-3 PUFA or placebo (olive oil) for at least 5 days before surgery (median, 16 days; range, 12 to 21 days). Phospholipid n-3 PUFA were measured in serum at study entry and at surgery and in right atrial appendage tissue at surgery. Echocardiography was used to assess left ventricular function and left atrial dimensions. Postoperative continuous ECG monitoring (Lifecard CF) for 5 days or until discharge, if earlier, was performed with a daily 12-lead ECG and clinical review if patients remained in the hospital beyond 5 days. Lifecard recordings were analyzed for episodes of atrial fibrillation (AF) ≥30 seconds (primary outcome). Clinical AF, AF burden (% time in AF), hospital stay, and intensive care/high dependency care stay were measured as secondary outcomes. One hundred three patients completed the study (51 in the placebo group and 52 in the n-3 PUFA group). There were no clinically relevant differences in baseline characteristics between groups. n-3 PUFA levels were higher in serum and right atrial tissue in the active treatment group. There was no significant difference between groups in the primary outcome of AF (95% confidence interval [CI], −6% to 30%, P =0.28) in any of the secondary outcomes or in AF-free survival. Conclusions— Omega-3 PUFA do not reduce the risk of AF after coronary artery bypass graft surgery. Clinical Trial Registration— www.ukcrn.org.uk. Identifier: 4437.
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Cites
Inflammation as a risk factor for atrial fibrillation
Aviles, R. J., Martin, D. O., Apperson-Hansen, C., Houghtaling, P. L., Rautaharju, P., Kronmal, R. A., Tracy, R. P., Van Wagoner, D. R., Psaty, B. M., Lauer, M. S., et al. (2003) · Circulation · doi:10.1161/01.cir.0000103131.70301.4f · Cited by 1,425
Postoperative atrial fibrillation and mortality after coronary artery bypass surgery
Villareal, R. P., Hariharan, R., Liu, B. C., Kar, B., Lee, V.-V., Elayda, M., Lopez, J. A., Rasekh, A., Wilson, J. M., & Massumi, A. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.11.023 · Cited by 715
Omega-3 polyunsaturated fatty acids and cardiovascular diseases.
Lavie, C. J., Milani, R. V., Mehra, M. R., & Ventura, H. O. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.02.084 · Cited by 644
Lack of benefit of dietary advice to men with angina: results of a controlled trial
Burr, M. L., Ashfield-Watt, P. A. L., Dunstan, F. D. J., Fehily, A. M., Breay, P., Ashton, T., Zotos, P. C., Haboubi, N. A. A., & Elwood, P. C. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601539 · Cited by 409
Raitt, M. H., Connor, W. E., Morris, C., Kron, J., Halperin, B., Chugh, S. S., McClelland, J., Cook, J., MacMurdy, K., Swenson, R., et al. (2005) · JAMA · doi:10.1001/jama.293.23.2884 · Cited by 371
Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake
Leaf, A., Albert, C. M., Josephson, M., Steinhaus, D., Kluger, J., Kang, J. X., Cox, B., Zhang, H., & Schoenfeld, D. (2005) · Circulation · doi:10.1161/circulationaha.105.549527 · Cited by 364
Thies, F., Miles, E. A., Nebe‐von‐Caron, G., Powell, J. R., Hurst, T. L., Newsholme, E. A., & Calder, P. C. (2001) · Lipids · doi:10.1007/s11745-001-0831-4 · Cited by 279
Self-citationEffect of fish oil on arrhythmias and mortality: systematic review.
Leon, H., Shibata, M. C., Sivakumaran, S., Dorgan, M., Chatterley, T., & Tsuyuki, R. T. (2008) · BMJ · doi:10.1136/bmj.a2931 · Cited by 223
Brouwer, I. A., Raitt, M. H., Dullemeijer, C., Kraemer, D. F., Zock, P. L., Morris, C., Katan, M. B., Connor, W. E., Camm, J. A., Schouten, E. G., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehp003 · Cited by 120 · cited 2×
“Incidence of AF in Lifecard monitor, % (n) 43% (22) 56% (29) 0.”
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418
Omega-3 Fatty Acids and Cardiovascular Disease
Mozaffarian, D., & Wu, J. H. Y. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.063 · Cited by 1,771
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403
Siscovick, D. S., Barringer, T. A., Fretts, A. M., Wu, J. H. Y., Lichtenstein, A. H., Costello, R. B., Kris-Etherton, P. M., Jacobson, T. A., Engler, M. B., Alger, H. M., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000482 · Cited by 629
Kowey, P. R., Reiffel, J. A., Ellenbogen, K. A., Naccarelli, G. V., & Pratt, C. M. (2010) · JAMA · doi:10.1001/jama.2010.1735 · Cited by 201
Metadata
- Authors
- Saravanan, P., Bridgewater, B., West, A. L., O'Neill, S. C., Calder, P. C., & Davidson, N. C.
- Venue
- Circulation: Arrhythmia and Electrophysiology
- Published
- 2010-02
- Volume
- 3
- Issue
- 1
- Pages
- 46-53
- ISSN
- 1941-3084 (ISSN-L)
- 1941-3149
- OpenAlex
- W2164843796
- Cited by
- 172
- References
- 9
- FWCI
- 23.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Omega-3 Fatty Acid Supplementation Does Not Reduce Risk of Atrial Fibrillation After Coronary Artery Bypass Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. https://app.cochat.ai/papers/10.1161/circep.109.899633
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- Saravanan, P., Bridgewater, B., West, A. L., O'Neill, S. C., Calder, P. C., & Davidson, N. C. (2010). Omega-3 Fatty Acid Supplementation Does Not Reduce Risk of Atrial Fibrillation After Coronary Artery Bypass Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Circulation: Arrhythmia and Electrophysiology. https://doi.org/10.1161/circep.109.899633
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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