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Cited by 371Fatty Acid Research and HealthCardiac electrophysiology and arrhythmiasCardiac pacing and defibrillation studies

Fish Oil Supplementation and Risk of Ventricular Tachycardia and Ventricular Fibrillation in Patients With Implantable Defibrillators: A Randomized Controlled Trial

Raitt, Merritt H., Connor, William E., Morris, Cynthia, Kron, Jack, Halperin, Blair, Chugh, Sumeet S., McClelland, James, Cook, James +10 more·2005·JAMA
DOI 10.1001/jama.293.23.2884
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Abstract

CONTEXT: Clinical studies of omega-3 polyunsaturated fatty acids (PUFAs) have shown a reduction in sudden cardiac death, suggesting that omega-3 PUFAs may have antiarrhythmic effects. OBJECTIVE: To determine whether omega-3 PUFAs have beneficial antiarrhythmic effects in patients with a history of sustained ventricular tachycardia (VT) or ventricular fibrillation (VF). DESIGN AND SETTING: Randomized, double-blind, placebo-controlled trial performed at 6 US medical centers with enrollment from February 1999 until January 2003. PATIENTS: Two hundred patients with an implantable cardioverter defibrillator (ICD) and a recent episode of sustained VT or VF. INTERVENTION: Patients were randomly assigned to receive fish oil, 1.8 g/d, 72% omega-3 PUFAs, or placebo and were followed up for a median of 718 days (range, 20-828 days). MAIN OUTCOME MEASURES: Time to first episode of ICD treatment for VT/VF, changes in red blood cell concentrations of omega-3 PUFAs, frequency of recurrent VT/VF events, and predetermined subgroup analyses. RESULTS: Patients randomized to receive fish oil had an increase in the mean percentage of omega-3 PUFAs in red blood cell membranes from 4.7% to 8.3% (P<.001), with no change observed in patients receiving placebo. At 6, 12, and 24 months, 46% (SE, 5%), 51% (5%), and 65% (5%) of patients randomized to receive fish oil had ICD therapy for VT/VF compared with 36% (5%), 41% (5%), and 59% (5%) for patients randomized to receive placebo (P = .19). In the subset of 133 patients whose qualifying arrhythmia was VT, 61% (SE, 6%), 66% (6%), and 79% (6%) of patients in the fish oil group had VT/VF at 6, 12, and 24 months compared with 37% (6%), 43% (6%), and 65% (6%) of patients in the control group (P = .007). Recurrent VT/VF events were more common in patients randomized to receive fish oil (P<.001). CONCLUSION: Among patients with a recent episode of sustained ventricular arrhythmia and an ICD, fish oil supplementation does not reduce the risk of VT/VF and may be proarrhythmic in some patients.

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  • Fish oil supplementation may be proarrhythmic in patients with recent sustained ventricular arrhythmia and an implantable cardiac defibrillator.

    “It was shown that among patients with a recent episode of sustained ventricular arrhythmia and an implantable cardiac defibrillator, fish oil supplementation might be proarrhythmic (137).”

    From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [137]

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Authors
Raitt, M. H., Connor, W. E., Morris, C., Kron, J., Halperin, B., Chugh, S. S., McClelland, J., Cook, J., MacMurdy, K., Swenson, R., Connor, S. L., Gerhard, G., Kraemer, D. F., Oseran, D., Marchant, C., Calhoun, D., Shnider, R., & McAnulty, J.
Affiliations
  • Oregon Health & Science University (US)
  • Providence St. Vincent Medical Center (US)
  • Tufts University (US)
  • Oregon State University (US)
Corresponding author
Raitt, Merritt H.
ORCID
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
2005-06-15
Volume
293
Issue
23
Pages
2884
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.293.23.2884
OpenAlex
W2099859189
Cited by
371
References
25
Citations by year
2025: 3 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 3 · 2018: 9 · 2017: 11 · 2016: 11 · 2015: 6 · 2014: 14 · 2013: 19 · 2012: 36
FWCI
40.55
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hl061682-04)
  • National Heart, Lung, and Blood Institute (R01HL61682)
  • National Center for Research Resources (M01RR000334, 5M01 RR00334)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords
omega-3 polyunsaturated fatty acids, ventricular tachycardia, ventricular fibrillation, implantable cardioverter-defibrillator, antiarrhythmic effect, red blood cell membrane fatty acids, recurrent arrhythmia, sudden cardiac death, arrhythmia recurrence, omega-3 deficiency
MeSH terms
Aged, Double-Blind Method, Erythrocyte Membrane, Female, Humans, Male, Middle Aged, Prospective Studies, Risk, Ventricular Fibrillation, Fatty Acids, Omega-3, Proportional Hazards Models, Survival Analysis, Defibrillators, Implantable, Tachycardia, Ventricular, Dietary Supplements

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