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Invasive Hemodynamic Assessment and Classification of In-Hospital Mortality Risk Among Patients With Cardiogenic Shock

Open access
Thayer, Katherine L., Zweck, Elric, Ayouty, Mohyee, Garan, A. Reshad, Hernandez-Montfort, Jaime, Mahr, Claudius, Morine, Kevin J., Newman, Sarah, Jorde, Lena, Haywood, Jillian L., Harwani, Neil M., Esposito, Michele L., Davila, Carlos D., Wencker, Detlef, Sinha, Shashank S., Vorovich, Esther, Abraham, Jacob, O’Neill, William, Udelson, James, Burkhoff, Daniel, Kapur, Navin K.·2020·Circulation: Heart Failure

Abstract

Background: Risk stratifying patients with cardiogenic shock (CS) is a major unmet need. The recently proposed Society for Cardiovascular Angiography and Interventions (SCAI) stages as an approach to identify patients at risk for in-hospital mortality remains under investigation. We studied the utility of the SCAI stages and further explored the impact of hemodynamic congestion on clinical outcomes. Methods: The CS Working Group registry includes patients with CS from 8 medical centers enrolled between 2016 and 2019. Patients were classified by the maximum SCAI stage (B–E) reached during their hospital stay according to drug and device utilization. In-hospital mortality was evaluated for association with SCAI stages and hemodynamic congestion. Results: Of the 1414 patients with CS, the majority were due to decompensated heart failure (50%) or myocardial infarction (MI; 35%). In-hospital mortality was 31% for the total cohort, but higher among patients with MI (41% versus 26%, MI versus heart failure, P <0.0001). Risk for in-hospital mortality was associated with increasing SCAI stage (odds ratio [95% CI], 3.25 [2.63–4.02]) in both MI and heart failure cohorts. Hemodynamic data was available in 1116 (79%) patients. Elevated biventricular filling pressures were common among patients with CS, and right atrial pressure was associated with increased mortality and higher SCAI Stage. Conclusions: Our findings support an association between the proposed SCAI staging system and in-hospital mortality among patient with heart failure and MI. We further identify that venous congestion is common and identifies patients with CS at high risk for in-hospital mortality. These findings provide may inform future management protocols and clinical studies.

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Metadata

Authors
Thayer, K. L., Zweck, E., Ayouty, M., Garan, A. R., Hernandez-Montfort, J., Mahr, C., Morine, K. J., Newman, S., Jorde, L., Haywood, J. L., Harwani, N. M., Esposito, M. L., Davila, C. D., Wencker, D., Sinha, S. S., Vorovich, E., Abraham, J., O’Neill, W., Udelson, J., Burkhoff, D., & Kapur, N. K.
Venue
Circulation: Heart Failure
Published
2020-09
Volume
13
Issue
9
Pages
e007099-e007099
ISSN
  • 1941-3289 (ISSN-L)
  • 1941-3297
OpenAlex
W3084394044
Cited by
319
References
17
FWCI
10.98
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Invasive Hemodynamic Assessment and Classification of In-Hospital Mortality Risk Among Patients With Cardiogenic Shock. https://app.cochat.ai/papers/10.1161/circheartfailure.120.007099
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Thayer, K. L., Zweck, E., Ayouty, M., Garan, A. R., Hernandez-Montfort, J., Mahr, C., Morine, K. J., Newman, S., Jorde, L., Haywood, J. L., Harwani, N. M., Esposito, M. L., Davila, C. D., Wencker, D., Sinha, S. S., Vorovich, E., Abraham, J., O’Neill, W., Udelson, J., . . . Kapur, N. K. (2020). Invasive Hemodynamic Assessment and Classification of In-Hospital Mortality Risk Among Patients With Cardiogenic Shock. Circulation: Heart Failure. https://doi.org/10.1161/circheartfailure.120.007099

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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