Erythropoietin in Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Randomized, Double-Blind Trial
Abstract
Background—: Erythropoietin improves myocardial function in experimental models of myocardial infarction. The aim of the present study was to determine the value of erythropoietin in patients with acute ST-elevation myocardial infarction. Methods and Results—: This randomized, double-blind study included 138 patients admitted with acute ST-elevation myocardial infarction and treated with primary percutaneous coronary intervention. Patients were randomly assigned to receive epoetin-β (3.33×104 U, n=68) or placebo (n=70) immediately and at 24 and 48 hours after percutaneous coronary intervention. The primary end point was left ventricular ejection fraction after 6 months measured by MRI. Other end points included infarct size at 5 days and 6 months. Clinical adverse events (death, recurrent myocardial infarction, stroke, and infarct-related artery revascularization) were investigated at 30 days and 6 months. Left ventricular ejection fraction at 6-month follow-up was 52.0±9.1% in the erythropoietin group compared with 51.8±9.3% in the placebo group ( P =0.92). Five days after percutaneous coronary intervention, left ventricular ejection fraction was 49.4±8.0% in the erythropoietin group and 50.8±7.3% in the placebo group ( P =0.32); infarct size was 26.8±20.9% and 28.3±24.4% ( P =0.76) and decreased to 17.3±14.3% and 20.9±16.4% at 6-month follow-up ( P =0.27). The cumulative 6-month incidence of death, recurrent myocardial infarction, stroke or target vessel revascularization was 13.2% in the erythropoietin group and 5.7% in the placebo group (hazard ratio, 2.36; 95% confidence interval, 0.73 to 7.66; P =0.15). Conclusions—: In patients with acute ST-elevation myocardial infarction treated with primary percutaneous coronary intervention, erythropoietin treatment did not improve left ventricular ejection fraction or reduce infarct size but may increase clinical adverse events. Clinical Trial Registration—: URL: http://www.clinicaltrials.gov . Unique identifier: NCT00390832.
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Randomized clinical studies in patients with CVD demonstrate that EPO administration increases the mortality after cardiovascular events.
“Randomized clinical studies in patients with CVD demonstrate that EPO administration increases the mortality after cardiovascular events (143).”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [143]
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- Authors
- Ott, I., Schulz, S., Mehilli, J., Fichtner, S., Hadamitzky, M., Hoppe, K., Ibrahim, T., Martinoff, S., Massberg, S., Laugwitz, K.-L., Dirschinger, J., Schwaiger, M., Kastrati, A., Schömig, A., & for the REVIVAL-3 Study Investigators
- Affiliations
- TUM Klinikum (DE)
- ORCID
- Venue
- Circulation: Cardiovascular Interventions
- Published
- 2010-10
- Volume
- 3
- Issue
- 5
- Pages
- 408-413
- ISSN
- 1941-7632 (ISSN-L)
- 1941-7640
- OpenAlex
- W2547303326
- Cited by
- 128
- References
- 20
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 10 · 2013: 18 · 2012: 21
- FWCI
- 12.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Cardiovascular Interventions (publishedVersion)
- Funders
- F. Hoffmann-La Roche
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- erythropoietin, epoetin beta, ST-elevation myocardial infarction, primary percutaneous coronary intervention, left ventricular ejection fraction, infarct size, myocardial function, myocardial salvage, adverse clinical events, reinfarction, target vessel revascularization, mortality, myocardial hypoxia, cardioprotection
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