Myocardial ischemia-reperfusion injury: a neglected therapeutic target
Open accessAbstract
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention (PPCI). However, the process of reperfusion can itself induce cardiomyocyte death, known as myocardial reperfusion injury, for which there is still no effective therapy. A number of new therapeutic strategies currently under investigation for preventing myocardial reperfusion injury have the potential to improve clinical outcomes in patients with acute MI treated with PPCI.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nano drug delivery vehicles accumulate in injured tissue due to inflammation-mediated increased vascular permeability in myocardial IR.
“In cases such as myocardial IR, nano drug delivery vehicles accumulate in the injured tissue due to inflammation-mediated increased vascular permeability.160”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [160]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Part of this paper’s reference list could not be split into single entries.
Yellon, D. M., & Hausenloy, D. J. (2007) · New England Journal of Medicine · doi:10.1056/nejmra071667 · Cited by 3,797 · see citing works
Self-citationZhao, Z., Corvera, J. S., Halkos, M. E., Kerendi, F., Wang, N.-P., Guyton, R. A., & Vinten‐Johansen, J. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01064.2002 · Cited by 2,073 · see citing works
Reimer, K. A., Lowe, J. E., Rasmussen, M. M., & Jennings, R. B. (1977) · Circulation · doi:10.1161/01.cir.56.5.786 · Cited by 1,944 · see citing works
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
Stefani, D. D., Raffaello, A., Teardo, E., Szabò, I., & Rizzuto, R. (2011) · Nature · doi:10.1038/nature10230 · Cited by 1,431 · see citing works
Przyklenk, K., Bauer, B., Ovize, M., Kloner, R. A., & Whittaker, P. (1993) · Circulation · doi:10.1161/01.cir.87.3.893 · Cited by 1,379 · see citing works
Myocardial reperfusion: a double-edged sword?
D, E. B. M., & Kloner, R. A. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112160 · Cited by 1,368 · see citing works
Wu, K. C., Zerhouni, E. A., Judd, R. M., Lugo-Olivieri, C. H., Barouch, L. A., Schulman, S. P., Blumenthal, R. S., & Lima, J. A. C. (1998) · Circulation · doi:10.1161/01.cir.97.8.765 · Cited by 1,356 · see citing works
Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction
Piot, C. A., Croisille, P., Staat, P., Thibault, H., Rioufol, G., Mewton, N., Belghiti, R. E., Cung, T. T., Bonnefoy‐Cudraz, E., Angoulvant, D., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa071142 · Cited by 1,339 · see citing works
Direct measurement of free radical generation following reperfusion of ischemic myocardium.
Zweier, J. L., Flaherty, J. T., & Weisfeldt, M. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1404 · Cited by 1,189 · see citing works
Ito, H., Tomooka, T., Sakai, N., Yu, H., Higashino, Y., Fujii, K., Masuyama, T., Kitabatake, A., & Minamino, T. (1992) · Circulation · doi:10.1161/01.cir.85.5.1699 · Cited by 1,052 · see citing works
Clinical Implications of the ‘No Reflow’ Phenomenon
Ito, H., Maruyama, A., Iwakura, K., Takiuchi, S., Masuyama, T., Hori, M., Higashino, Y., Fujii, K., & Minamino, T. (1996) · Circulation · doi:10.1161/01.cir.93.2.223 · Cited by 1,022 · see citing works
Postconditioning the Human Heart
Staat, P., Rioufol, G., Piot, C. A., Cottin, Y., Cung, T. T., L’Huillier, I., Aupetit, J., Bonnefoy‐Cudraz, E., Finet, G., André‐Fouët, X., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.558122 · Cited by 1,004 · see citing works
Bøtker, H. E., Kharbanda, R. K., Schmidt, M. R., Bøttcher, M., Kaltoft, A., Terkelsen, C. J., Munk, K., Andersen, N. H., Hansen, T. M., Trautner, S., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(09)62001-8 · Cited by 989 · see citing works
Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion
Griffiths, E. J., & Halestrap, A. P. (1995) · Biochemical Journal · doi:10.1042/bj3070093 · Cited by 838 · see citing works
Ferdinandy, P., Schulz, R., & Baxter, G. F. (2007) · Pharmacological Reviews · doi:10.1124/pr.107.06002 · Cited by 738 · see citing works
Transient Limb Ischemia Induces Remote Ischemic Preconditioning In Vivo
Kharbanda, R. K., Mortensen, U. M., White, P. A., Kristiansen, S. B., Schmidt, M. R., Hoschtitzky, J. A., Vogel, M., Sørensen, K. E., Redington, A. N., & MacAllister, R. J. (2002) · Circulation · doi:10.1161/01.cir.0000043806.51912.9b · Cited by 707 · see citing works
Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury
Vinten-Johansen, J. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.10.011 · Cited by 676 · see citing works
Hausenloy, D. J., Mwamure, P. K., Venugopal, V., Harris, J., Barnard, M., Grundy, E. M., Ashley, E., Vichare, S., Salvo, C. D., Kolvekar, S. K., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61296-3 · Cited by 676 · see citing works
Self-citationThe CREATE-ECLA Trial Group Investigators* (2005) · JAMA · doi:10.1001/jama.293.4.437 · Cited by 635 · see citing works
A fresh look at reperfusion injury.
Piper, H., Garcia-Dorado, D., & Ovize, M. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00033-9 · Cited by 633 · see citing works
Ross, A. M., Gibbons, R. J., Stone, G. W., Kloner, R. A., & Alexander, R. W. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.061 · Cited by 608 · see citing works
Hausenloy, D. J. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00455-8 · Cited by 586 · see citing works
Self-citationCheung, M., Kharbanda, R., Konstantinov, I., Shimizu, M., Frndova, H., Li, J., Holtby, H., Cox, P., Smallhorn, J., Arsdell, G. V., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.01.066 · Cited by 572 · see citing works
Remote ischaemic preconditioning: underlying mechanisms and clinical application
Hausenloy, D. J., & Yellon, D. M. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn114 · Cited by 557 · see citing works
Self-citationExenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction
Lønborg, J., Vejlstrup, N., Kelbæk, H., Bøtker, H. E., Kim, W. Y., Mathiasen, A. B., Jørgensen, E. O., Helqvist, S., Saunamäki, K. I., Clemmensen, P. M., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr309 · Cited by 550 · see citing works
Aletras, A. H., Tilak, G. S., Natanzon, A., Hsu, L., Gonzalez, F. M., Hoyt, R. F., & Arai, A. E. (2006) · Circulation · doi:10.1161/circulationaha.105.576025 · Cited by 527 · see citing works
Friedrich, M. G., Abdel‐Aty, H., Taylor, A. J., Schulz‐Menger, J., Messroghli, D., & Dietz, R. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.01.019 · Cited by 509 · see citing works
Ovize, M., Baxter, G. F., Lisa, F. D., Ferdinandy, P., David Garcia-dorado, A., Hausenloy, D. J., Heusch, G., Vinten-Johansen, J., Yellon, D. M., & Schulz, R. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq129 · Cited by 502 · see citing works
Self-citationHombach, V., Grebe, O. C., Merkle, N., Waldenmaier, S., Höher, M., Kochs, M., Wöhrle, J., & Kestler, H. A. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi147 · Cited by 496 · see citing works
Rochitte, C. E., Lima, J. A. C., Bluemke, D. A., Reeder, S. B., McVeigh, E. R., Furuta, T., Becker, L. C., & Melin, J. A. (1998) · Circulation · doi:10.1161/01.cir.98.10.1006 · Cited by 492 · see citing works
Kitakaze, M., Asakura, M., Kim, J., Shintani, Y., Asanuma, H., Hamasaki, T., Seguchi, O., Myoishi, M., Minamino, T., Ohara, T., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61634-1 · Cited by 477 · see citing works
The APEX AMI Investigators (2007) · JAMA · doi:10.1001/jama.297.1.43 · Cited by 447 · see citing works
Hearse, D. J. (1973) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(73)90030-8 · Cited by 447 · see citing works
Vakeva, A., Agah, A., Rollins, S. M., Matis, L. A., Li, L., & Stahl, G. L. (1998) · Circulation · doi:10.1161/01.cir.97.22.2259 · Cited by 441 · see citing works
Medical and Cellular Implications of Stunning, Hibernation, and Preconditioning
Kloner, R. A., Bolli, R., Marbán, E., Reinlib, L., & D, E. B. M. (1998) · Circulation · doi:10.1161/01.cir.97.18.1848 · Cited by 438 · see citing works
Cardiac Remote Ischemic Preconditioning in Coronary Stenting (CRISP Stent) Study
Hoole, S. P., Heck, P. M., Sharples, L. D., Khan, S. N., Duehmke, R. M., Densem, C. G., Clarke, S., Shapiro, L. M., Schofield, P. M., O'Sullivan, M., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.809723 · Cited by 435 · see citing works
Long-Term Benefit of Postconditioning
Thibault, H., Piot, C. A., Staat, P., Bontemps, L., Sportouch, C., Rioufol, G., Cung, T. T., Bonnefoy‐Cudraz, E., Angoulvant, D., Aupetit, J., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.729780 · Cited by 433 · see citing works
Myocardial Protection at a Crossroads: The Need for Translation Into Clinical Therapy
Bolli, R., Becker, L., Gross, G., Mentzer, R., Balshaw, D., & Lathrop, D. A. (2004) · Circulation Research · doi:10.1161/01.res.0000137171.97172.d7 · Cited by 428 · see citing works
Eitel, I., Desch, S., Fuernau, G. F., Hildebrand, L., Gutberlet, M., Schuler, G. C., & Thiele, H. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.01.049 · Cited by 427 · see citing works
Hausenloy, D. J. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.09.025 · Cited by 419 · see citing works
Self-citationHeusch, G., Kleinbongard, P., Böse, D., Levkau, B., Haude, M., Schulz, R., & Erbel, R. (2009) · Circulation · doi:10.1161/circulationaha.109.888784 · Cited by 419 · see citing works
Mitochondria-Targeted Small Molecule Therapeutics and Probes
Smith, R. A. J., Hartley, R. C., & Murphy, M. P. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.3969 · Cited by 399 · see citing works
Granger, C., Mahaffey, K., Weaver, W., Théroux, P., Hochman, J., Filloon, T., Rollins, S., Todaro, T. G., Nicolau, J., Rużyl̷l̷o, W., et al. (2003) · Circulation · doi:10.1161/01.cir.0000087447.12918.85 · Cited by 392 · see citing works
Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury
Argaud, L., Gateau-Roesch, O., Muntean, D. M., Chalabreysse, L., Loufouat, J., Robert, D., & Ovize, M. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.12.001 · Cited by 359 · see citing works
Hausenloy, D. J. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00043-9 · Cited by 322 · see citing works
Self-citationThe pH Hypothesis of Postconditioning
Cohen, M. V., Yang, X., & Downey, J. M. (2007) · Circulation · doi:10.1161/circulationaha.106.675710 · Cited by 297 · see citing works
L, X., Tsao, P. S., & Lefer, A. M. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115427 · Cited by 295 · see citing works
Gáname, J., Messalli, G., Dymarkowski, S., Rademakers, F. E., Desmet, W. J., de Werf, F. V., & Bogaert, J. G. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp093 · Cited by 293 · see citing works
Loukogeorgakis, S., Williams, R., Panagiotidou, A. T., Kolvekar, S. K., Donald, A. E., Cole, T. J., Yellon, D. M., Deanfield, J. E., & MacAllister, R. J. (2007) · Circulation · doi:10.1161/circulationaha.106.653782 · Cited by 288 · see citing works
Self-citationBlood Supply of the Myocardium after Temporary Coronary Occlusion
Krug, A., de Rochemont, W. D. M., & Korb, G. (1966) · Circulation Research · doi:10.1161/01.res.19.1.57 · Cited by 288 · see citing works
Inhibition of mitochondrial permeability transition pore opening: the holy grail of cardioprotection
Heusch, G., Boengler, K., & Schulz, R. (2010) · Basic Research in Cardiology · doi:10.1007/s00395-009-0080-9 · Cited by 281 · see citing works
Na+/h+exchange inhibitors for cardioprotective therapy: progress, problems and prospects
Avkiran, M., & Marber, M. S. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01693-5 · Cited by 269 · see citing works
Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes
Qian, T., Nieminen, A., Herman, B. A., & Lemasters, J. J. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.6.c1783 · Cited by 258 · see citing works
Lønborg, J., Kelbæk, H., Vejlstrup, N. G., Jørgensen, E. O., Helqvist, S., Saunamäki, K. I., Clemmensen, P. M., Holmvang, L., Treiman, M., Jensen, J. S., et al. (2010) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.109.905521 · Cited by 253 · see citing works
Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations
Hausenloy, D. J., Baxter, G. F., Bell, R., Bøtker, H. E., Davidson, S. M., Downey, J. M., Heusch, G., Kitakaze, M., Lecour, S., Mentzer, R. M., et al. (2010) · Basic Research in Cardiology · doi:10.1007/s00395-010-0121-4 · Cited by 244 · see citing works
Self-citationNo-reflow phenomenon and prognosis in patients with acute myocardial infarction
Ito, H. (2006) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0632 · Cited by 238 · see citing works
Iwakura, K., Ito, H., Takiuchi, S., Taniyama, Y., Nakatsuchi, Y., Negoro, S., Higashino, Y., Okamura, A., Masuyama, T., Hori, M., et al. (1996) · Circulation · doi:10.1161/01.cir.94.6.1269 · Cited by 238 · see citing works
Götberg, M., Olivecrona, G. K., Koul, S. M., Carlsson, M., Engblom, H., Ugander, M., van der Pals, J., Algotsson, L., Arheden, H., & Erlinge, D. (2010) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.110.957902 · Cited by 231 · see citing works
Rentoukas, I., Γιαννόπουλος, Γ., Kaoukis, A., Kossyvakis, C., Raisakis, K., Driva, M., Panagopoulou, V., Tsarouchas, K., Vavetsi, S., Pyrgakis, V. N., et al. (2010) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2009.10.015 · Cited by 227 · see citing works
Freixa, X., Bellera, N., Ortiz-Pérez, J. T., Jiménez, M., Paré, C., Bosch, X., de Caralt, T. M., Betriu, A., & Masotti, M. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr297 · Cited by 227 · see citing works
Thielmann, M., Kottenberg, E., Boengler, K., Raffelsieper, C., Neuhäeuser, M., Peters, J., Jakob, H. G., & Heusch, G. (2010) · Basic Research in Cardiology · doi:10.1007/s00395-010-0104-5 · Cited by 223 · see citing works
Beshansky, J. R. (2012) · JAMA · doi:10.1001/jama.2012.426 · Cited by 216 · see citing works
New Horizons in Cardioprotection
Longacre, L. S., Kloner, R. A., Arai, A. E., Baines, C. P., Bolli, R., D, E. B. M., Downey, J. M., Gibbons, R. J., Gottlieb, R. A., Heusch, G., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.032698 · Cited by 216 · see citing works
Self-citationSTAT5 Activation and Cardioprotection by Remote Ischemic Preconditioning in Humans
Heusch, G., Musiolik, J., Kottenberg, E., Peters, J., Jakob, H. G., & Thielmann, M. (2011) · Circulation Research · doi:10.1161/circresaha.111.259556 · Cited by 214 · see citing works
Lønborg, J., Kelbæk, H., Vejlstrup, N., Bøtker, H. E., Kim, W. Y., Holmvang, L., Jørgensen, E. O., Helqvist, S., Saunamäki, K. I., Terkelsen, C. J., et al. (2012) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.112.968388 · Cited by 210 · see citing works
Effect of Cyclosporine on Left Ventricular Remodeling After Reperfused Myocardial Infarction
Mewton, N., Croisille, P., Gahide, G., Rioufol, G., Bonnefoy‐Cudraz, E., Sanchez, I., Cung, T. T., Sportouch, C., Angoulvant, D., Finet, G., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.10.052 · Cited by 198 · see citing works
Kirsti Ytrehus, B., Liu, Y., Tsuchida, A., Miura, T., Liu, G. S., Yang, X. M., Herbert, D., Cohen, M. V., & Downey, J. M. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.267.6.h2383 · Cited by 189 · see citing works
Cardiac protection during acute myocardial infarction: Where do we stand in 2004?
Kloner, R. A., & Rezkalla, S. H. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.03.068 · Cited by 185 · see citing works
Kim, J.-S., Kim, J., Choi, D., Lee, C. J., Lee, S. H., Ko, Y.-G., Hong, M.-K., Kim, B.-K., Oh, S. J., Jeon, D. W., et al. (2010) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2009.11.021 · Cited by 183 · see citing works
Scintigraphic evidence of the “No reflow” phenomenon in human beings after coronary thrombolysis
Schofer, J. J., Montz, R., & Mathey, D. G. (1985) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(85)80381-8 · Cited by 183 · see citing works
Effect of temperature on myocardial infarction in swine
Duncker, D. J., Klassen, C. L., Ishibashi, Y., Herrlinger, S. H., Pavek, T., & Bache, R. J. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.4.h1189 · Cited by 181 · see citing works
Hearse, D. J., & Tósaki, Á. (1987) · Circulation Research · doi:10.1161/01.res.60.3.375 · Cited by 180 · see citing works
Effect of postconditioning on infarct size in patients with ST elevation myocardial infarction
Sörensson, P., Saleh, N., Bouvier, F., Böhm, F., Settergren, M., Caidahl, K., Tornvall, P., Arheden, H., Rydén, L., & Pernow, J. (2010) · Heart · doi:10.1136/hrt.2010.199430 · Cited by 177 · see citing works
The pH paradox in ischemia-reperfusion injury to cardiac myocytes
Lemasters, J. J., Bond, J. M., Chacon, E., Harper, I. S., Kaplan, S. H., Ohata, H., Trollinger, D. R., Herman, B. A., & Cascio, W. E. (1996) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8988-9_7 · Cited by 165 · see citing works
Atar, D., Petzelbauer, P., Schwitter, J., Huber, K., Rensing, B. J. W. M., Kasprzak, J. D., Butter, C., Grip, L., Hansen, P. R., Süselbeck, T., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.12.017 · Cited by 163 · see citing works
Mitochondrial permeability transition pore as a target for cardioprotection in the human heart
Shanmuganathan, S., Hausenloy, D. J., Duchen, M. R., & Yellon, D. M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01192.2004 · Cited by 161 · see citing works
Self-citationMiyamae, M., Camacho, S. A., Weiner, M. W., & Figueredo, V. M. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.5.h2145 · Cited by 160 · see citing works
Stone, G. W., Martin, J. L., de Boer, M., Margheri, M., Bramucci, E., Blankenship, J. C., Metzger, D. C., Gibbons, R. J., Lindsay, B., Weiner, B. H., et al. (2009) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.108.840066 · Cited by 160 · see citing works
Heusch, G. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.06.013 · Cited by 156 · see citing works
A single dose of erythropoietin in ST-elevation myocardial infarction
Voors, A. A., Belonje, A. M. S., Zijlstra, F., Hillege, H. L., Anker, S. D., Slart, R. H. J. A., Tio, R. A., Hof, A. W. J. V. ’., Jukema, J. W., Peels, H. O., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq304 · Cited by 144 · see citing works
Acute Myocardial Infarction With Hyperoxemic Therapy (AMIHOT)
O’Neill, W. W., Martin, J. L., Dixon, S. R., Bartorelli, A. L., Trabattoni, D., Oemrawsingh, P. V., Atsma, D. E., Chang, M., Marquardt, W., Oh, J. K., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.01.099 · Cited by 134 · see citing works
Doukas, J., Wrasidlo, W., Noronha, G., Dneprovskaia, E., Fine, R., Weis, S. M., Hood, J. D., DeMaria, A. N., Söll, R., & Cheresh, D. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606956103 · Cited by 132 · see citing works
Bogaert, J. G., Kalantzi, M. V., Rademakers, F. E., Dymarkowski, S., & Janssens, S. P. (2007) · European Radiology · doi:10.1007/s00330-007-0627-9 · Cited by 128 · see citing works
Ott, I., Schulz, S., Mehilli, J., Fichtner, S., Hadamitzky, M., Hoppe, K., Ibrahim, T., Martinoff, S., Massberg, S., Laugwitz, K.-L., et al. (2010) · Circulation: Cardiovascular Interventions · doi:10.1161/circinterventions.109.904425 · Cited by 128 · see citing works
Remote Ischemic Conditioning in Patients With Myocardial Infarction Treated With Primary Angioplasty
Munk, K., Andersen, N. H., Schmidt, M. R., Nielsen, S. S., Terkelsen, C. J., Sloth, E., Bøtker, H. E., Nielsen, T. T., & Poulsen, S. H. (2010) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.110.957340 · Cited by 126 · see citing works
MRI in acute myocardial infarction
Marra, M. P., Lima, J. A. C., & Iliceto, S. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq409 · Cited by 126 · see citing works
Hayward, R. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00266-1 · Cited by 125 · see citing works
Kleinbongard, P., Böse, D., Baars, T., Möhlenkamp, S., Konorza, T. F. M., Schöner, S., Elter-Schulz, M., Eggebrecht, H., Degen, H., Haude, M., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.235713 · Cited by 121 · see citing works
Postconditioning during coronary angioplasty in acute myocardial infarction: the POST-AMI trial
Tarantini, G., Favaretto, E., Marra, M. P., Frigo, A. C., Napodano, M., Cacciavillani, L., Giovagnoni, A., Renda, P., Biasio, V. D., Plebani, M., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.03.136 · Cited by 120 · see citing works
Cyclosporine A at Reperfusion Reduces Infarct Size in Pigs
Skyschally, A., Schulz, R., & Heusch, G. (2010) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-010-6219-y · Cited by 119 · see citing works
Fujita, M., Asanuma, H., Hirata, A., Wakeno, M., Takahama, H., Sasaki, H., Kim, J., Takashima, S., Tsukamoto, O., Minamino, T., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01051.2006 · Cited by 118 · see citing works
Lund, G., Stork, A., Muellerleile, K., Barmeyer, A. A., Bansmann, M. P., Knefel, M., Schlichting, U., Müller, M., Verde, P. E., Adam, G., et al. (2007) · Radiology · doi:10.1148/radiol.2451061219 · Cited by 117 · see citing works
Cardiac preconditioning for ischaemia: lost in translation
Ludman, A. J., Yellon, D. M., & Hausenloy, D. J. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.003855 · Cited by 115 · see citing works
Self-citationGradual Reperfusion Reduces Infarct Size and Endothelial Injury but Augments Neutrophil Accumulation
Sato, H., Jordan, J. E., Zhao, Z., Sarvotham, S. S., & Vinten‐Johansen, J. (1997) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(97)00734-0 · Cited by 107 · see citing works
Zhao, Z., Nakamura, M., Wang, N.-P., Velez, D. A., Hewan-Lowe, K. O., Guyton, R. A., & Vinten-Johansen, J. (2000) · Journal of Surgical Research · doi:10.1006/jsre.2000.6029 · Cited by 105 · see citing works
Delayed Postconditioning in the Mouse Heart In Vivo
Roubille, F., Franck-Miclo, A., Covinhes, A., Lafont, C., Cransac, F., Combes, S., Vincent, A., Fontanaud, P., Sportouch, C., Redt‐Clouet, C., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.031864 · Cited by 92 · see citing works
Low-pressure reperfusion alters mitochondrial permeability transition
Bopassa, J.-C., Michel, P., Gateau-Roesch, O., Ovize, M., & Ferrera, R. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01081.2004 · Cited by 82 · see citing works
T2-weighted CMR of the area at risk—a risky business?
Wince, W. B., & Kim, R. J. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2010.124 · Cited by 80 · see citing works
Gao, E., Boucher, M., Chuprun, J. K., Zhou, R., Eckhart, A. D., & Koch, W. J. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00227.2007 · Cited by 80 · see citing works
Bär, F. W. H. M., Tzivoni, D., Dirksen, M. T., Fernández‐Ortíz, A., Heyndrickx, G. R., Brachmann, J., Reiber, J. H. C., Avasthy, N., Tatsuno, J., Davies, M., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl304 · Cited by 79 · see citing works
Zhao, Z., Lefer, D. J., Sato, H., Hart, K. K., Jefforda, R. R., & Vinten-Johansen, J. (1997) · Journal of Leukocyte Biology · doi:10.1002/jlb.62.3.292 · Cited by 79 · see citing works
Musiolik, J., van Caster, P., Skyschally, A., Boengler, K., Gres, P., Schulz, R., & Heusch, G. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp271 · Cited by 78 · see citing works
(2000) · European Heart Journal · doi:10.1053/euhj.1999.2439 · Cited by 76 · see citing works
Ludman, A. J., Yellon, D. M., Hasleton, J. M., Ariti, C. A., Babu, G. G., Boston‐Griffiths, E., Venugopal, V., Walker, J. M., Holdright, D. R., Swanton, H., et al. (2011) · Heart · doi:10.1136/hrt.2011.223867 · Cited by 75 · see citing works
Self-citationReduction of infarct size by ischaemic post-conditioning in humans: fact or fiction?
Heusch, G. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr341 · Cited by 66 · see citing works
Mewton, N., Rapacchi, S., Augeul, L., Ferrera, R., Loufouat, J., Boussel, L., Micolich, A., Rioufol, G., Revel, D., Ovize, M., et al. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0214-8 · Cited by 65 · see citing works
Postconditioning for protection of the infarcting heart
Yellon, D. M., & Opie, L. H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68157-9 · Cited by 64 · see citing works
Self-citationHahn, J., Kim, H.-J., Choi, Y. J., Jo, S., Kim, H. J., Lee, S., Ahn, K.-J., Song, Y. B., Choi, J., Choi, S., et al. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.08.011 · Cited by 56 · see citing works
Post, S., Post, M. C., den Branden, B. J. V., Eefting, F. D., Goumans, M., Stella, P. R., van Es, H. W., Wildbergh, T. X., Rensing, B. J. W. M., & Doevendans, P. A. (2012) · Catheterization and Cardiovascular Interventions · doi:10.1002/ccd.23449 · Cited by 50 · see citing works
Kalantzi, M. V., Janssens, S. P., Rademakers, F. E., & Bogaert, J. G. (2006) · Journal of Cardiovascular Magnetic Resonance · Cited by 48 · see citing works
Herzog, W. R., Vogel, R. A., Schlossberg, M. L., Edenbaum, L. R., Scott, H. J., & Serebruany, V. L. (1997) · International Journal of Cardiology · doi:10.1016/s0167-5273(96)02883-5 · Cited by 45 · see citing works
The ST-Segment–Elevation Myocardial Infarction Chain of Survival
Ornato, J. P. (2007) · Circulation · doi:10.1161/circulationaha.107.710970 · Cited by 29 · see citing works
Spears, J. R., Prcevski, P., Jiang, A. J., Brereton, G. J., & Heide, R. V. (2006) · International Journal of Cardiology · doi:10.1016/j.ijcard.2005.11.099 · Cited by 28 · see citing works
Luo, A. K., & Wu, K. C. (2006) · Heart Failure Reviews · doi:10.1007/s10741-006-0231-0 · Cited by 23 · see citing works
Flagged first, then by citations
1 of the 115 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Schwartz LL, et al. New horizons in cardioprotec- tion: recommendations from the 2010 national heart, lung, and blood institute workshop. Circula- tion. 2011;124(10):1172-1179.
Cited by
Sorted by citations
Mitochondrial dynamics in health and disease: mechanisms and potential targets
Chen, W., Zhao, H., & Li, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01547-9 · Cited by 1,306 · see citing works
Myocardial ischaemia–reperfusion injury and cardioprotection in perspective
Heusch, G. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0403-y · Cited by 1,271 · see citing works
Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease
Re, D. P. D., Amgalan, D., Linkermann, A., Liu, Q., & Kitsis, R. N. (2019) · Physiological Reviews · doi:10.1152/physrev.00022.2018 · Cited by 979 · see citing works
Kalogeris, T. J., Baines, C. P., Krenz, M., & Korthuis, R. J. (2016) · Comprehensive physiology · doi:10.1002/cphy.c160006 · Cited by 841 · see citing works
Mitochondria as a therapeutic target for common pathologies
Murphy, M. P., & Hartley, R. C. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.174 · Cited by 832 · see citing works
ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection
Cadenas, S. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.01.024 · Cited by 821 · see citing works
CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis
Zhang, T., Zhang, Y., Cui, M., Jin, L., Wang, Y., Lv, F., Liu, Y., Zheng, W., Shang, H., Zhang, J., et al. (2016) · Nature Medicine · doi:10.1038/nm.4017 · Cited by 790 · see citing works
Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Zhang, M., Liu, Q., Meng, H., Duan, H., Liu, X., Wu, J., Gao, F., Wang, S., Tan, R., & Yuan, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01688-x · Cited by 773 · see citing works
Zhao, J., Li, X., Hu, J., Chen, F., Qiao, S., Sun, X., Gao, L., Xie, J., & Xu, B. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz040 · Cited by 769 · see citing works
A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury
Chouchani, E. T., Pell, V. R., James, A. M., Work, L. M., Saeb-Parsy, K., Frezza, C., Krieg, T., & Murphy, M. P. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.009 · Cited by 752 · see citing works
Pathophysiology of Myocardial Infarction
Frangogiannis, N. G. (2015) · Comprehensive physiology · doi:10.1002/cphy.c150006 · Cited by 717 · see citing works
Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury
Davidson, S. M., Ferdinandy, P., Andreadou, I., Bøtker, H. E., Heusch, G., Ibáñez, B., Ovize, M., Schulz, R., Yellon, D. M., Hausenloy, D. J., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.09.086 · Cited by 710 · see citing works
Self-citationLavie, L. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.07.003 · Cited by 692 · see citing works
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works
Pan, X., Liu, J., Nguyen, T. T. M., Liu, C., Sun, J., Teng, Y., Fergusson, M. M., Rovira, I. I., Allen, M. D., Springer, D., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2868 · Cited by 645 · see citing works
Mitochondrial uncoupling, ROS generation and cardioprotection
Cadenas, S. (2018) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2018.05.019 · Cited by 591 · see citing works
Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics
Li, Z.-M., Xu, S., & Liu, P. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.193 · Cited by 567 · see citing works
Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury
Vicencio, J. M., Yellon, D. M., Sivaraman, V., Das, D. K., Boi-Doku, C., Arjun, S., Zheng, Y. H., Riquelme, J. A., Kearney, J., Sharma, V., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.02.026 · Cited by 541 · see citing works
Self-citationGuidelines for experimental models of myocardial ischemia and infarction
Lindsey, M. L., Bolli, R., Canty, J. M., Du, X.-J., Frangogiannis, N. G., Frantz, S., Gourdie, R. G., Holmes, J. W., Jones, S. P., Kloner, R. A., et al. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00335.2017 · Cited by 526 · see citing works
Arginase: A Multifaceted Enzyme Important in Health and Disease
Caldwell, R. W., Rodriguez, P. C., Toque, H. A., Narayanan, S. P., & Caldwell, R. B. (2018) · Physiological Reviews · doi:10.1152/physrev.00037.2016 · Cited by 495 · see citing works
Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise
Song, H.-H. G., Rumma, R. T., Ozaki, C. K., Edelman, E. R., & Chen, C. S. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.02.009 · Cited by 476 · see citing works
Halestrap, A. P., & Richardson, A. P. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.08.018 · Cited by 466 · see citing works
Broch, K., Anstensrud, A. K., Woxholt, S., Sharma, K., Tøllefsen, I. M., Bendz, B., Aakhus, S., Ueland, T., Amundsen, B. H., Damås, J. K., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.02.049 · Cited by 457 · see citing works
Cai, W., Liu, L., Shi, X., Liu, Y., Wang, J., Fang, X., Chen, Z., Ai, D., Zhu, Y., & Zhang, X. (2023) · Circulation · doi:10.1161/circulationaha.122.060257 · Cited by 452 · see citing works
Huang, L. S., Hong, Z., Wu, W., Xiong, S., Zhong, M., Gao, X., Rehman, J., & Malik, A. B. (2020) · Immunity · doi:10.1016/j.immuni.2020.02.002 · Cited by 435 · see citing works
Wang, Z. V., Deng, Y., Gao, N., Pedrozo, Z., Li, D. ‘., Morales, C. R., Criollo, A., Luo, X., Tan, W. H., Jiang, N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.014 · Cited by 406 · see citing works
The Role of Oxidative Stress in Cardiac Disease: From Physiological Response to Injury Factor
D’Oria, R., Schipani, R., Leonardini, A., Natalicchio, A., Perrini, S., Cignarelli, A., Laviola, L., & Giorgino, F. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5732956 · Cited by 387 · see citing works
Inflammation and fibrosis in murine models of heart failure
Bacmeister, L., Schwarzl, M., Warnke, S., Stoffers, B., Blankenberg, S., Westermann, D., & Lindner, D. (2019) · Basic Research in Cardiology · doi:10.1007/s00395-019-0722-5 · Cited by 384 · see citing works
Neri, M., Riezzo, I., Pascale, N., Pomara, C., & Turillazzi, E. (2017) · Mediators of Inflammation · doi:10.1155/2017/7018393 · Cited by 376 · see citing works
Acute ischemic stroke therapy overview
Catanese, L., Tarsia, J., & Fisher, M. (2017) · Circulation Research · doi:10.1161/circresaha.116.309278 · Cited by 341 · see citing works
GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury
Shi, H., Gao, Y., Dong, Z., Yang, J., Gao, R., Li, X., Zhang, S., Ma, L., Sun, X., Wang, Z., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.318629 · Cited by 341 · see citing works
Zordoky, B. N. M., Robertson, I. M., & Dyck, J. R. B. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.016 · Cited by 340 · see citing works
Thrombo-inflammation in acute ischaemic stroke — implications for treatment
Stoll, G., & Nieswandt, B. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0221-1 · Cited by 336 · see citing works
Longterm Exercise-Derived Exosomal miR-342-5p
Hou, Z., Qin, X., Hu, Y., Zhang, X., Li, G., Wu, J., Li, J., Sha, J., Chen, J., Xia, J., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314635 · Cited by 333 · see citing works
van Hout, G. P. J., Bosch, L., Ellenbroek, G. H. J. M., de Haan, J. J., van Solinge, W. W., Cooper, M. A., Arslan, F., de Jager, S. C. A., Robertson, A. A. B., Pasterkamp, G., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw247 · Cited by 332 · see citing works
Hausenloy, D. J., Bøtker, H. E., Engstrøm, T., Erlinge, D., Heusch, G., Ibáñez, B., Kloner, R. A., Ovize, M., Yellon, D. M., & García‐Dorado, D. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw145 · Cited by 326 · see citing works
Self-citationOng, S., Samangouei, P., Kalkhoran, S. B., & Hausenloy, D. J. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.11.005 · Cited by 323 · see citing works
Self-citationLi, Y., Chen, B., Yang, X., Zhang, C., Yao, J., Li, P., Liu, Y., Li, Z., Qiao, B., Lau, W. B., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.039262 · Cited by 317 · see citing works
Microvesicles and exosomes: new players in metabolic and cardiovascular disease
Lawson, C., Vicencio, J. M., Yellon, D. M., & Davidson, S. M. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0201 · Cited by 316 · see citing works
Self-citationMacrophages in cardiac remodelling after myocardial infarction
Yap, J., Irei, J. S., Lozano-Gerona, J., Vanapruks, S., Bishop, T., & Boisvert, W. A. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00823-5 · Cited by 316 · see citing works
Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery
Hausenloy, D. J., Barrabés, J. A., Bøtker, H. E., Davidson, S. M., Lisa, F. D., Downey, J. M., Engstrøm, T., Ferdinandy, P., Carbrera-Fuentes, H. A., Heusch, G., et al. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0588-8 · Cited by 309 · see citing works
Self-citationSeropian, I. M., Toldo, S. A., Tassell, B. W. V., & Abbate, A. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.01.014 · Cited by 296 · see citing works
Kapur, N. K., Alkhouli, M. A., DeMartini, T. J., Faraz, H. A., George, Z. H., Goodwin, M. J., Hernández-Montfort, J., Iyer, V., Josephy, N., Kalra, S., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.038269 · Cited by 278 · see citing works
He, J., Liu, D., Zhao, L., Zhou, D., Rong, J., Zhang, L., & Xia, Z. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11357 · Cited by 278 · see citing works
Application of the Nano-Drug Delivery System in Treatment of Cardiovascular Diseases
Deng, Y., Zhang, X., Shen, H., He, Q., Wu, Z., Liao, W., & Yuan, M. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00489 · Cited by 263 · see citing works
Varasteh, Z., Mohanta, S. K., Robu, S., Braeuer, M., Li, Y., Omidvari, N., Topping, G. J., Sun, T., Nekolla, S. G., Richter, A., et al. (2019) · Journal of Nuclear Medicine · doi:10.2967/jnumed.119.226993 · Cited by 260 · see citing works
Ferroptosis and its emerging roles in cardiovascular diseases
Li, N., Jiang, W., Wang, W., Xiong, R., Wu, X., & Geng, Q. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105466 · Cited by 254 · see citing works
Metformin: An Old Drug with New Applications
Zhou, J. Y., Massey, S., Story, D. T., & Li, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102863 · Cited by 236 · see citing works
The Coronary Circulation as a Target of Cardioprotection
Heusch, G. (2016) · Circulation Research · doi:10.1161/circresaha.116.308640 · Cited by 233 · see citing works
New insights into IGF-1 signaling in the heart
Troncoso, R., Ibarra, C., Vicencio, J. M., Jaimovich, E., & Lavandero, S. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.12.002 · Cited by 232 · see citing works
Clinical benefits and pharmacology of scutellarin: A comprehensive review
Wang, L., & Ma, Q. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.05.006 · Cited by 231 · see citing works
Neutrophil stunning by metoprolol reduces infarct size
García‐Prieto, J., Villena-Gutiérrez, R., Gómez, M., Bernardo, E., Pun-García, A., García‐Lunar, I., Crainiciuc, G., Fernández‐Jiménez, R., Sreeramkumar, V., Martinez-Bourio, R., et al. (2017) · Nature Communications · doi:10.1038/ncomms14780 · Cited by 218 · see citing works
Jiang, L., Yin, X., Chen, Y., Chen, Y., Jiang, W., Zheng, H., Huang, F., Liu, B., Zhou, W., Qi, L., et al. (2020) · Theranostics · doi:10.7150/thno.43895 · Cited by 217 · see citing works
Tetramethylpyrazine: A review on its mechanisms and functions
Lin, J., Wang, Q., Zhou, S., Xu, S., & Yao, K. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113005 · Cited by 217 · see citing works
Uric acid aggravates myocardial ischemia–reperfusion injury via ROS/NLRP3 pyroptosis pathway
Shen, S., He, F., Cheng, C., Xu, B., & Sheng, J. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110990 · Cited by 216 · see citing works
Davidson, S. M., Adameová, A., Barile, L., Cabrera-Fuentes, H. A., Lazou, A., Pagliaro, P., Stensløkken, K., García‐Dorado, D., & (CA16225), T. E. C. A. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15127 · Cited by 206 · see citing works
Rodrigo, R., Libuy, M., Feliú, F., & Hasson, D. (2013) · Disease Markers · doi:10.1155/2013/974358 · Cited by 205 · see citing works
Cyclosporine A in Reperfused Myocardial Infarction
Ottani, F., Latini, R., Staszewsky, L. I., Vecchia, L. L., Locuratolo, N., Sicuro, M., Masson, S., Barlera, S., Milani, V., Lombardi, M., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.10.081 · Cited by 202 · see citing works
Wei, Z., Qiao, S., Zhao, J., Liu, Y., Li, Q., Wei, Z., Dai, Q., Kang, L., & Xu, B. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116632 · Cited by 202 · see citing works
Ma, S., Sun, L., Wu, W., Jiang-li, W., Sun, Z., & Ren, J. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.551318 · Cited by 202 · see citing works
RetractedMitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases
Whitaker, R. M., Corum, D. G., Beeson, C., & Schnellmann, R. G. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103155 · Cited by 200 · see citing works
Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury
Zhou, T., Chuang, C., & Zuo, L. (2015) · BioMed Research International · doi:10.1155/2015/864946 · Cited by 200 · see citing works
The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury
Kuznetsov, A. V., Javadov, S. A., Margreiter, R., Grimm, M. F., Hagenbuchner, J., & Ausserlechner, M. J. (2019) · Antioxidants · doi:10.3390/antiox8100454 · Cited by 199 · see citing works
Oxidative Stress-Mediated Blood-Brain Barrier (BBB) Disruption in Neurological Diseases
Song, K., Li, Y., Zhang, H., An, N., Wei, Y., Wang, L., Tian, C., Yuan, M., Sun, Y., Xing, Y., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4356386 · Cited by 199 · see citing works
ESPOSITO, M. L., Zhang, Y., Qiao, X., Reyelt, L. A., Paruchuri, V., Schnitzler, G. R., Morine, K., Annamalai, S., Bogins, C., NATOV, P. S., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.05.034 · Cited by 195 · see citing works
Oxidative Stress and Antioxidant Treatments in Cardiovascular Diseases
Wang, W., & Kang, P. M. (2020) · Antioxidants · doi:10.3390/antiox9121292 · Cited by 192 · see citing works
Mapping immune cell infiltration using restricted diffusion MRI
Yeh, F.-C. F., Liu, L., Hitchens, T. K., & Wu, Y. L. (2016) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26143 · Cited by 188 · see citing works
Zhu, H., Tan, Y., Du, W., Li, Y., Toan, S., Mui, D., Tian, F., & Zhou, H. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101777 · Cited by 188 · see citing works
The SLC9A-C Mammalian Na + /H + Exchanger Family: Molecules, Mechanisms, and Physiology
Pedersen, S. F., & Counillon, L. (2019) · Physiological Reviews · doi:10.1152/physrev.00028.2018 · Cited by 187 · see citing works
Mechanical Unloading in Heart Failure
Uriel, N. Y., SAYER, G. T., Annamalai, S., Kapur, N. K., & Burkhoff, D. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.05.038 · Cited by 186 · see citing works
Lahnwong, C., Palee, S., Apaijai, N., Sriwichaiin, S., Kerdphoo, S., Jaiwongkam, T., Chattipakorn, S. C., & Chattipakorn, N. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01066-9 · Cited by 186 · see citing works
Silvis, M. J. M., Dengler, S. E. K. G., Odille, C. A., Mishra, M., van der Kaaij, N. P., Doevendans, P. A., Sluijter, J. P. G., de Kleijn, D. P. V., de Jager, S. C. A., Bosch, L., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.599511 · Cited by 183 · see citing works
Future directions of acute ischaemic stroke therapy
Fisher, M., & Saver, J. L. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00054-x · Cited by 180 · see citing works
Pathological Roles of Iron in Cardiovascular Disease
Kobayashi, M., Suhara, T., Baba, Y., Kawasaki, N. K., Higa, J. K., & Matsui, T. (2018) · Current Drug Targets · doi:10.2174/1389450119666180605112235 · Cited by 179 · see citing works
Zhu, W., Sun, L. V., Zhao, P., Liu, Y., Zhang, J., Zhang, Y., Hong, Y., Zhu, Y., Lu, Y., Zhao, W., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00808-5 · Cited by 175 · see citing works
Clearance of senescent cells during cardiac ischemia–reperfusion injury improves recovery
Dookun, E., Walaszczyk, A., Redgrave, R., Palmowski, P., Tual‐Chalot, S., Suwana, A., Chapman, J., Jirkovsky, E., Donastorg Sosa, L., Gill, E., et al. (2020) · Aging Cell · doi:10.1111/acel.13249 · Cited by 173 · see citing works
Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation
Mauler, M., Herr, N., Schönichen, C., Witsch, T., Marchini, T., Härdtner, C., Koentges, C., Kienle, K., Ollivier, V., Schell, M., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.033942 · Cited by 173 · see citing works
MicroRNA-210 Controls Mitochondrial Metabolism and Protects Heart Function in Myocardial Infarction
Song, R., Dasgupta, C., Mulder, C., & Zhang, L. (2022) · Circulation · doi:10.1161/circulationaha.121.056929 · Cited by 168 · see citing works
Intramyocardial haemorrhage after acute myocardial infarction
Betgem, R. P., de Waard, G. A., Nijveldt, R., Beek, A. M., Escaned, J., & van Royen, N. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.188 · Cited by 167 · see citing works
Advances and challenges in conductive hydrogels: From properties to applications
Zhou, C., Wu, T., Xie, X., Song, G., Ma, X., Mu, Q., Huang, Z., Liu, X., Sun, C., & Xu, W. (2022) · European Polymer Journal · doi:10.1016/j.eurpolymj.2022.111454 · Cited by 167 · see citing works
Wei, Z., Chen, Z., Zhao, Y., Fan, F., Xiong, W., Song, S., Yin, Y., Hu, J., Yang, K., Yang, L., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121000 · Cited by 163 · see citing works
McFadyen, J. D., Kiefer, J., Braig, D., Loseff-Silver, J., Potempa, L. A., Eisenhardt, S. U., & Peter, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01351 · Cited by 160 · see citing works
T lymphocytes and fractalkine contribute to myocardial ischemia/reperfusion injury in patients
Boag, S. E., Das, R., Shmeleva, E. V., Bagnall, A. J., Egred, M., Howard, N. J., Bennaceur, K., Zaman, A., Keavney, B. D., & Spyridopoulos, I. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80055 · Cited by 158 · see citing works
Francisco, J. J., & Re, D. P. D. (2023) · Antioxidants · doi:10.3390/antiox12111944 · Cited by 160 · see citing works
Zhang, S., Yan, F., Luan, F., Chai, Y., Li, N., Wang, Y., Chen, Z.-L., Xu, D., & Tang, Y. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155649 · Cited by 158 · see citing works
Horio, E., Kadomatsu, T., Miyata, K., Arai, Y., Hosokawa, K., Doi, Y., Ninomiya, T., Horiguchi, H., Endo, M., Tabata, M., et al. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.303116 · Cited by 157 · see citing works
Bejarano, J., Navarro-Márquez, M., Morales-Zavala, F., Morales, J. O., García‐Carvajal, I., Araya, E., Flores, Y., Verdejo, H., Castro, P., Lavandero, S., et al. (2018) · Theranostics · doi:10.7150/thno.26284 · Cited by 156 · see citing works
Xiaodong, Y., He, Y., Wang, S., Wong, G. T. C., Irwin, M. G., & Xia, Z. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2018.37 · Cited by 153 · see citing works
Chen, H.-Y., Xiao, Z.-Z., Ling, X., Xu, R.-N., Zhu, P., & Zheng, S. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00271-w · Cited by 153 · see citing works
Yang, Y., Hong, Y., Nam, G., Chung, J. H., Koh, E., & Kim, I. (2017) · Advanced Materials · doi:10.1002/adma.201605604 · Cited by 151 · see citing works
Roles of mitochondrial dynamics modulators in cardiac ischaemia/reperfusion injury
Maneechote, C., Palee, S., Chattipakorn, S. C., & Chattipakorn, N. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13330 · Cited by 151 · see citing works
Frankenreiter, S., Bednarczyk, P., Kniess, A., Bork, N. I., Straubinger, J., Koprowski, P., Wrzosek, A., Mohr, E., Logan, A., Murphy, M. P., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.028723 · Cited by 151 · see citing works
Bi, X., Zhang, G., Wang, X., Nguyen, C., May, H. I., Li, X., Al‐Hashimi, A., Austin, R. C., Gillette, T. G., Fu, G., et al. (2018) · Circulation Research · doi:10.1161/circresaha.117.312641 · Cited by 151 · see citing works
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
Gong, G. Q., Bilanges, B., Allsop, B., Masson, G. R., Roberton, V. H., Askwith, T., Oxenford, S. J., Madsen, R. R., Conduit, S. E., Bellini, D., et al. (2023) · Nature · doi:10.1038/s41586-023-05972-2 · Cited by 151 · see citing works
Self-citationValls-Lacalle, L., Barba, I., Miró‐Casas, E., Alburquerque-Béjar, J. J., Ruiz‐Meana, M., Fuertes‐Agudo, M., Rodríguez‐Sinovas, A., & David Garcia-dorado, A. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv279 · Cited by 149 · see citing works
Succinate metabolism: a new therapeutic target for myocardial reperfusion injury
Pell, V. R., Chouchani, E. T., Frezza, C., Murphy, M. P., & Krieg, T. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw100 · Cited by 149 · see citing works
Li, X., Dai, Y., Yan, S., Shi, Y., Han, B., Li, J., Cha, L., & Mu, J. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.005 · Cited by 147 · see citing works
Chen, Q., Liu, Y., Ding, X., Li, Q., Qiu, F., Wang, M., Shen, Z., Zheng, H., & Fu, G. (2020) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03671-z · Cited by 146 · see citing works
Zou, Y., Li, L., Li, Y., Chen, S., Xie, X., Jin, X., Wang, X., Ma, C., Fan, G., & Wang, W. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c16481 · Cited by 146 · see citing works
Platelets in cardiac ischaemia/reperfusion injury: a promising therapeutic target
Ziegler, M., Wang, X., & Peter, K. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz070 · Cited by 145 · see citing works
- Authors
- Hausenloy, D. J., & Yellon, D. M.
- Affiliations
- University College London (GB)
- Corresponding author
- Yellon, Derek M.
- Venue
- Journal of Clinical Investigation
- Published
- 2013-01-02
- Volume
- 123
- Issue
- 1
- Pages
- 92-100
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3533275
- OpenAlex
- W2051395985
- Cited by
- 2,357
- References
- 115
- Citations by year
- 2026: 176 · 2025: 177 · 2024: 226 · 2023: 218 · 2022: 236 · 2021: 231 · 2020: 240 · 2019: 226 · 2018: 172 · 2017: 124 · 2016: 130 · 2015: 101 · 2014: 69 · 2013: 28 · 2012: 1
- FWCI
- 16.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0510-10164)
- British Heart Foundation (RG/03/007, RG/08/015/26411, FS/06/023)
- University College London
- Medical Research Council (MR/K002066/1)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- myocardial ischemia-reperfusion injury, acute myocardial infarction, cardiomyocyte death, primary percutaneous coronary intervention, thrombolysis, therapeutic target, cardioprotection
- MeSH terms
- Animals, Humans, Myocardial Infarction, Myocardial Reperfusion Injury, Thrombolytic Therapy, Cell Death, Myocytes, Cardiac, Percutaneous Coronary Intervention
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
