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Cited by 607

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Refined Balloon Pulmonary Angioplasty for Inoperable Patients with Chronic Thromboembolic Pulmonary Hypertension

Mizoguchi, Hiroki, Ogawa, Aiko, Munemasa, Mitsuru, Mikouchi, Hiroshi, Ito, Hiroshi, Matsubara, Hiromi·2012·Circulation: Cardiovascular Interventions

Abstract

Background—: Although balloon pulmonary angioplasty (BPA) for inoperable patients with chronic thromboembolic pulmonary hypertension was first reported over a decade ago, its clinical application has been restricted because of limited efficacy and complications. We have refined the procedure of BPA to maximize its clinical efficacy. Methods and Results—: Sixty-eight consecutive patients with inoperable chronic thromboembolic pulmonary hypertension underwent BPA. We evaluated pulmonary artery diameters and determined the appropriate balloon size by using intravascular ultrasound. We performed BPA in a staged fashion over multiple, separate procedures to maximize efficacy and reduce the risk of reperfusion pulmonary injury. A total of 4 (2–8) sessions were performed in each patient, and the number of vessels dilated per session was 3 (1–14). The World Health Organization functional class improved from 3 to 2 ( P <0.01), and mean pulmonary arterial pressure was decreased from 45.4±9.6 to 24.0±6.4 mm Hg ( P <0.01). One patient died because of right heart failure 28 days after BPA. During follow-up for 2.2±1.4 years after the final BPA, another patient died of pneumonia, and the remaining 66 patients are alive. In 57 patients who underwent right heart catheterization at follow-up, improvement of mean pulmonary arterial pressure was maintained (24.0±5.8 mm Hg at 1.0±0.9 years). Forty-one patients (60%) developed reperfusion pulmonary injury after BPA, but mechanical ventilation was required in only 4 patients. Conclusions—: Our refined BPA procedure improves clinical status and hemodynamics of inoperable patients with chronic thromboembolic pulmonary hypertension, with a low mortality. A refined BPA procedure could be considered as a therapeutic approach for patients with inoperable chronic thromboembolic pulmonary hypertension.

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Metadata

Authors
Mizoguchi, H., Ogawa, A., Munemasa, M., Mikouchi, H., Ito, H., & Matsubara, H.
Venue
Circulation: Cardiovascular Interventions
Published
2012-12
Volume
5
Issue
6
Pages
748-755
ISSN
  • 1941-7632 (ISSN-L)
  • 1941-7640
OpenAlex
W2106794486
Cited by
607
References
21
FWCI
22.53
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Refined Balloon Pulmonary Angioplasty for Inoperable Patients with Chronic Thromboembolic Pulmonary Hypertension. https://app.cochat.ai/papers/10.1161/circinterventions.112.971077
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Mizoguchi, H., Ogawa, A., Munemasa, M., Mikouchi, H., Ito, H., & Matsubara, H. (2012). Refined Balloon Pulmonary Angioplasty for Inoperable Patients with Chronic Thromboembolic Pulmonary Hypertension. Circulation: Cardiovascular Interventions. https://doi.org/10.1161/circinterventions.112.971077

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