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Cited by 116Atrial Fibrillation Management and OutcomesPhysical Activity and HealthCardiovascular and exercise physiology

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

Physical Activity and the Risk of Incident Atrial Fibrillation in Women

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Everett, Brendan M., Conen, David, Buring, Julie E., Moorthy, M.V., Lee, I-Min, Albert, Christine M.·2011·Circulation: Cardiovascular Quality and Outcomes
DOI 10.1161/circoutcomes.110.951442PMC PMC3097307
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Abstract

Background—: Physical activity (PA) is well known to reduce the risk of cardiovascular disease. We hypothesized that regular PA, possibly acting through reductions in blood pressure and body mass index (BMI), would reduce the risk of incident atrial fibrillation (AF) in women. Methods and Results—: We prospectively followed 34 759 women who reported their leisure-time PA levels for the occurrence of AF. We estimated energy expenditure in metabolic equivalent (MET)-h/wk and validated self-reported AF with medical records. The mean (SD) age of the 34 759 participants was 54.6 (7.0) years, the mean BMI was 26.0 (5.0) kg/m 2 , 26.5% had hypertension, and the median (IQR) PA was 8.4 (2.8, 20.4) MET-h/wk. After a median of 14.4 years of observation, 968 women had development of AF. In age-, cholesterol-, smoking-, alcohol-, diabetes-, and race-adjusted models, increasing quintiles of PA were associated with reduced risks of AF (hazard ratio for extreme quintiles, 0.82; 0.66 to 1.01; P trend=0.007 over quintiles). Although this association was not substantially different after adjusting for hypertension (0.87; 0.70 to 1.07; P trend 0.02), it was attenuated after adjustment for BMI (0.99; 0.80 to 1.23; P trend=0.22). Women who achieved the federal government's recommendation of 7.5 MET-h/wk of PA were at reduced risk of AF compared with those who did not (0.86; 0.75 to 0.98; P =0.03). This association was also attenuated by BMI (0.96; 0.84 to 1.10; P =0.57). Conclusions—: In middle-aged women, physical activity was associated with a modestly reduced risk of AF. However, this relationship was no longer significant after controlling for body mass index.

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Metadata

Authors
Everett, B. M., Conen, D., Buring, J. E., Moorthy, M. V., Lee, I.-M., & Albert, C. M.
Affiliations
Brigham and Women's Hospital (US)
ORCID
Venue
Circulation: Cardiovascular Quality and Outcomes
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2011-05
Volume
4
Issue
3
Pages
321-327
ISSN
  • 1941-7705 (ISSN-L)
  • 1941-7713
DOI
10.1161/circoutcomes.110.951442
PMC
PMC3097307
OpenAlex
W2147818589
Cited by
116
References
43
Citations by year
2026: 4 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 19 · 2020: 14 · 2019: 8 · 2018: 12 · 2017: 6 · 2016: 9 · 2015: 10 · 2014: 5 · 2013: 8 · 2012: 6
FWCI
4.38
Type
journal article
Language
en
Open access
Locations
  • Circulation Cardiovascular Quality and Outcomes (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5r01hl043851-10)
  • National Heart, Lung, and Blood Institute (R01HL080467, HL043851, HL-093613, R01‐HL043851, HL099355, R21HL093613, RC1HL099355, HL080467)
  • National Cancer Institute (CA 047988, R01CA047988)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
physical activity, atrial fibrillation, women, body mass index, hypertension, energy expenditure, leisure-time physical activity, middle-aged women, cardiovascular risk
MeSH terms
Atrial Fibrillation, Blood Pressure, Electrocardiography, Female, Follow-Up Studies, Humans, Middle Aged, Motor Activity, Prospective Studies, Risk Factors, Body Mass Index, Incidence, Self Report

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