The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.
Physical Activity and the Risk of Incident Atrial Fibrillation in Women
Open accessAbstract
Background—: Physical activity (PA) is well known to reduce the risk of cardiovascular disease. We hypothesized that regular PA, possibly acting through reductions in blood pressure and body mass index (BMI), would reduce the risk of incident atrial fibrillation (AF) in women. Methods and Results—: We prospectively followed 34 759 women who reported their leisure-time PA levels for the occurrence of AF. We estimated energy expenditure in metabolic equivalent (MET)-h/wk and validated self-reported AF with medical records. The mean (SD) age of the 34 759 participants was 54.6 (7.0) years, the mean BMI was 26.0 (5.0) kg/m 2 , 26.5% had hypertension, and the median (IQR) PA was 8.4 (2.8, 20.4) MET-h/wk. After a median of 14.4 years of observation, 968 women had development of AF. In age-, cholesterol-, smoking-, alcohol-, diabetes-, and race-adjusted models, increasing quintiles of PA were associated with reduced risks of AF (hazard ratio for extreme quintiles, 0.82; 0.66 to 1.01; P trend=0.007 over quintiles). Although this association was not substantially different after adjusting for hypertension (0.87; 0.70 to 1.07; P trend 0.02), it was attenuated after adjustment for BMI (0.99; 0.80 to 1.23; P trend=0.22). Women who achieved the federal government's recommendation of 7.5 MET-h/wk of PA were at reduced risk of AF compared with those who did not (0.86; 0.75 to 0.98; P =0.03). This association was also attenuated by BMI (0.96; 0.84 to 1.10; P =0.57). Conclusions—: In middle-aged women, physical activity was associated with a modestly reduced risk of AF. However, this relationship was no longer significant after controlling for body mass index.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In women, vigorous exercise has not been shown to increase AF risk, although moderate exercise is associated with a lower risk of AF than sedentary lifestyle.47,48”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [48]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Impact of Atrial Fibrillation on the Risk of Death: The Framingham Heart Study
Benjamin, E. J., Wolf, P. A., D’Agostino, R. B., Silbershatz, H., Kannel, W. B., & Levy, D. (1998) · Circulation · doi:10.1161/01.cir.98.10.946 · Cited by 4,575
Compendium of Physical Activities: Classification of energy costs of human physical activities
AINSWORTH, B. E., HASKELL, W. L., LEON, A. S., JACOBS, D. R., MONTOYE, H. J., SALLIS, J. F., & PAFFENBARGER, R. S. (1993) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199301000-00011 · Cited by 4,102
Benjamin, E. J. (1994) · JAMA · doi:10.1001/jama.1994.03510350050036 · Cited by 2,613
Miyasaka, Y., Barnes, M. E., Gersh, B. J., Cha, S. S., Bailey, K. R., Abhayaratna, W. P., Seward, J. B., & Tsang, T. S. M. (2006) · Circulation · doi:10.1161/circulationaha.105.595140 · Cited by 2,564
Rothman, K. J., Greenland, S., & Lash, T. L. (1998) · Cited by 2,096
Kannel, W. B., Wolf, P. A., Benjamin, E. J., & Levy, D. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00583-9 · Cited by 2,033
Effect of Aerobic Exercise on Blood Pressure: A Meta-Analysis of Randomized, Controlled Trials
Whelton, S. P., Chin, A., Xin, X., & He, J. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-136-7-200204020-00006 · Cited by 1,970
Stewart, S., Hart, C. L., Hole, D. J., & McMurray, J. J. V. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01236-6 · Cited by 1,562
Krahn, A. D., Manfreda, J., TATE, R. B., Mathewson, F. A. L., & Cuddy, T. E. (1995) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)80348-9 · Cited by 1,478
Incidence of and risk factors for atrial fibrillation in older adults
Psaty, B. M., Manolio, T. A., Kuller, L. H., Kronmal, R. A., Cushman, M., Fried, L. P., White, R., Furberg, C. D., & Rautaharju, P. M. (1997) · Circulation · doi:10.1161/01.cir.96.7.2455 · Cited by 1,462
Obesity and the risk of new-onset atrial fibrillation
Wang, T. J. (2004) · JAMA · doi:10.1001/jama.292.20.2471 · Cited by 1,427
Walking Compared with Vigorous Exercise for the Prevention of Cardiovascular Events in Women
Manson, J. E., Greenland, P., LaCroix, A. Z., Stefanick, M. L., Mouton, C. P., Oberman, A., Perri, M. G., Sheps, D. S., Pettinger, M. B., & Siscovick, D. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021067 · Cited by 1,349
Reproducibility and validity of a self-administered physical activity questionnaire
WOLF, A. M., HUNTER, D. J., COLDITZ, G. A., MANSON, J. E., STAMPFER, M. J., CORSANO, K. A., ROSNER, B., KRISKA, A., & WILLETT, W. C. (1994) · International Journal of Epidemiology · doi:10.1093/ije/23.5.991 · Cited by 1,038
Triggering of Sudden Death from Cardiac Causes by Vigorous Exertion
Albert, C. M., Mittleman, M. A., Chae, C. U., Lee, I.-M., Hennekens, C. H., & Manson, J. E. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011093431902 · Cited by 1,020
Self-citationPhysical Activity and Reduced Risk of Cardiovascular Events: Potential Mediating Mechanisms
Mora, S., Cook, N., Buring, J. E., Ridker, P. M., & Lee, I.-M. (2007) · Circulation · doi:10.1161/circulationaha.107.729939 · Cited by 1,000
Self-citationExercise Type and Intensity in Relation to Coronary Heart Disease in Men
Tanasescu, M. (2002) · JAMA · doi:10.1001/jama.288.16.1994 · Cited by 928
The Incidence of Primary Cardiac Arrest during Vigorous Exercise
Siscovick, D. S., Weiss, N. S., Fletcher, R. H., & Lasky, T. (1984) · New England Journal of Medicine · doi:10.1056/nejm198410043111402 · Cited by 838
Impact of Atrial Fibrillation on Mortality, Stroke, and Medical Costs
Wolf, P. A., Mitchell, J. B., Baker, C. S., Kannel, W. B., & D’Agostino, R. B. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.3.229 · Cited by 683
Physical Activity and Coronary Heart Disease in Women
Lee, I.-M. M., Rexrode, K. M., Cook, N. R., Manson, J. E., & Buring, J. E. (2001) · JAMA · doi:10.1001/jama.285.11.1447 · Cited by 552
Self-citationThe Long- and Short-Term Impact of Elevated Body Mass Index on the Risk of New Atrial Fibrillation
Tedrow, U. B., Conen, D., Ridker, P. M., Cook, N. R., Koplan, B. A., Manson, J. E., Buring, J. E., & Albert, C. M. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.02.029 · Cited by 500
Self-citationMozaffarian, D., Furberg, C. D., Psaty, B. M., & Siscovick, D. (2008) · Circulation · doi:10.1161/circulationaha.108.785626 · Cited by 476
Electrical Stimulation to Identify Neural Elements on the Heart: Their Role in Atrial Fibrillation
Scherlag, B. J., Nakagawa, H., Jackman, W. M., Yamanashi, W. S., Patterson, E. S., Po, S. S., & Lazzara, R. (2005) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-005-2492-2 · Cited by 425
Paroxysmal Atrial Fibrillation: A Disorder of Autonomic Tone?
Coumel, P. (1994) · European Heart Journal · doi:10.1093/eurheartj/15.suppl_a.9 · Cited by 422
Relation of vigorous exercise to risk of atrial fibrillation
Aizer, A., Gaziano, J. M., Cook, N. R., Manson, J. E., Buring, J. E., & Albert, C. M. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.01.374 · Cited by 383
Self-citationSinus node disease and arrhythmias in the long-term follow-up of former professional cyclists
Baldesberger, S., Bauersfeld, U., CANDINAS, R., Seifert, B., Zuber, M., Ritter, M., Jenni, R., Oechslin, E. N., Luthi, P., Scharf, C., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm555 · Cited by 352
MURPHY, M. H., Nevill, A. M., Murtagh, E., & HOLDER, R. L. (2006) · Preventive Medicine · doi:10.1016/j.ypmed.2006.12.008 · Cited by 344
Physical Activity and Weight Gain Prevention
Lee, I.-M. (2010) · JAMA · doi:10.1001/jama.2010.312 · Cited by 331
Self-citationLong-lasting sport practice and lone atrial fibrillation
Mont, L. (2002) · European Heart Journal · doi:10.1053/euhj.2001.2802 · Cited by 331
Molina, L., Mont, L., Marrugat, J., Berruezo, A., Brugada, J., Bruguera, J., Rebato, C., & Elosua, R. (2008) · EP Europace · doi:10.1093/europace/eun071 · Cited by 327
Lone atrial fibrillation in vigorously exercising middle aged men: case-control study
Karjalainen, J., Kujala, U. M., Kaprio, J., Sarna, S., & Viitasalo, M. (1998) · BMJ · doi:10.1136/bmj.316.7147.1784 · Cited by 326
Conen, D., Tedrow, U. B., Koplan, B. A., Glynn, R. J., Buring, J. E., & Albert, C. M. (2009) · Circulation · doi:10.1161/circulationaha.108.830042 · Cited by 312
Self-citationNonuniform Distribution of Vagal Effects on the Atrial Refractory Period
Alessi, R., Nusynowitz, M. L., Abildskov, J. A., & Moe, G. K. (1958) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1958.194.2.406 · Cited by 307
Endurance sport practice as a risk factor for atrial fibrillation and atrial flutter
Mont, L., Elosua, R., & Brugada, J. (2008) · Europace · doi:10.1093/europace/eun289 · Cited by 287
Mont, L., Tamborero, D., Elosua, R., Molina, I., Coll-Vinent, B., Sitges, M., Vidal, B., Scalise, A., Tejeira, A., Berruezo, A., et al. (2008) · EP Europace · doi:10.1093/europace/eum263 · Cited by 270
Sizer, T. R. (1991) · Educational leadership · Cited by 269
Sport practice and the risk of lone atrial fibrillation: a case-control study
Elosua, R., Arquer, A., Mont, L., Sambola, A., Molina, L., García-Morán, E., Brugada, J., & Marrugat, J. (2006) · International Journal of Cardiology · doi:10.1016/j.ijcard.2005.05.020 · Cited by 250
Physical Exertion, Exercise, and Sudden Cardiac Death in Women
Whang, W., Manson, J. E., Hu, F. B., Chae, C. U., Rexrode, K. M., Willett, W. C., Stampfer, M. J., & Albert, C. M. (2006) · JAMA · doi:10.1001/jama.295.12.1399 · Cited by 192
Self-citation(1998) · PubMed · Cited by 152
Paroxysmal atrial fibrillation in male endurance athletes. A 9-year follow up
Hoogsteen, J. (2004) · Europace · doi:10.1016/j.eupc.2004.01.004 · Cited by 134
The effects of exercise and training on human cardiovascular reflex control
O’Sullivan, S. E., & Bell, C. (2000) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(00)00148-x · Cited by 118
Leisure-Time Physical Activity and the Risk of Primary Cardiac Arrest
Lemaitre, R. N., Siscovick, D. S., Raghunathan, T. E., Weinmann, S., Arbogast, P., & Lin, D.-Y. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.7.686 · Cited by 114
Frost, L., Frost, P., & Vestergaard, P. F. (2004) · Occupational and Environmental Medicine · doi:10.1136/oem.2004.014266 · Cited by 50
Cited by
Sorted by citations
Epidemiology of Atrial Fibrillation in the 21st Century
Kornej, J., Börschel, C. S., Benjamin, E. J., & Schnabel, R. B. (2020) · Circulation Research · doi:10.1161/circresaha.120.316340 · Cited by 1,625
The Clinical Profile and Pathophysiology of Atrial Fibrillation
Andrade, J. G., Khairy, P., Dobrev, D., & Nattel, S. (2014) · Circulation Research · doi:10.1161/circresaha.114.303211 · Cited by 1,232
Andrade, J. G., Aguilar, M., Atzema, C. L., Bell, A., Cairns, J. A., Cheung, C. C., Cox, J. L., Dorian, P., Gladstone, D. J., Healey, J. S., et al. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.09.001 · Cited by 593
Chung, M. K., Eckhardt, L. L., Chen, L. Y., Ahmed, H. M., Gopinathannair, R., Joglar, J. A., Noseworthy, P. A., Pack, Q. R., Sanders, P., & Trulock, K. M. (2020) · Circulation · doi:10.1161/cir.0000000000000748 · Cited by 565
Epidemiology and modifiable risk factors for atrial fibrillation
Elliott, A. D., Middeldorp, M. E., Gelder, I. C. V., Albert, C. M., & Sanders, P. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00820-8 · Cited by 392
Self-citation
Metadata
- Authors
- Everett, B. M., Conen, D., Buring, J. E., Moorthy, M. V., Lee, I.-M., & Albert, C. M.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Circulation: Cardiovascular Quality and Outcomes
- Published
- 2011-05
- Volume
- 4
- Issue
- 3
- Pages
- 321-327
- ISSN
- 1941-7705 (ISSN-L)
- 1941-7713
- PMC
- PMC3097307
- OpenAlex
- W2147818589
- Cited by
- 116
- References
- 43
- Citations by year
- 2026: 4 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 19 · 2020: 14 · 2019: 8 · 2018: 12 · 2017: 6 · 2016: 9 · 2015: 10 · 2014: 5 · 2013: 8 · 2012: 6
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Cardiovascular Quality and Outcomes (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01hl043851-10)
- National Heart, Lung, and Blood Institute (R01HL080467, HL043851, HL-093613, R01‐HL043851, HL099355, R21HL093613, RC1HL099355, HL080467)
- National Cancer Institute (CA 047988, R01CA047988)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- physical activity, atrial fibrillation, women, body mass index, hypertension, energy expenditure, leisure-time physical activity, middle-aged women, cardiovascular risk
- MeSH terms
- Atrial Fibrillation, Blood Pressure, Electrocardiography, Female, Follow-Up Studies, Humans, Middle Aged, Motor Activity, Prospective Studies, Risk Factors, Body Mass Index, Incidence, Self Report
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
