The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Nuclear Shape, Mechanics, and Mechanotransduction
Open accessAbstract
In eukaryotic cells, the nucleus contains the genome and is the site of transcriptional regulation. The nucleus is the largest and stiffest organelle and is exposed to mechanical forces transmitted through the cytoskeleton from outside the cell and from force generation within the cell. Here, we discuss the effect of intra- and extracellular forces on nuclear shape and structure and how these force-induced changes could be implicated in nuclear mechanotransduction, ie, force-induced changes in cell signaling and gene transcription. We review mechanical studies of the nucleus and nuclear structural proteins, such as lamins. Dramatic changes in nuclear shape, organization, and stiffness are seen in cells where lamin proteins are mutated or absent, as in genetically engineered mice, RNA interference studies, or human disease. We examine the different mechanical pathways from the force-responsive cytoskeleton to the nucleus. We also highlight studies that link changes in nuclear shape with cell function during developmental, physiological, and pathological modifications. Together, these studies suggest that the nucleus itself may play an important role in the response of the cell to force.
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Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
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Local force and geometry sensing regulate cell functions
Vogel, V., & Sheetz, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1890 · Cited by 2,328
Cellular mechanotransduction: putting all the pieces together again
Ingber, D. E. (2006) · The FASEB Journal · doi:10.1096/fj.05-5424rev · Cited by 1,627
Goldman, R. D., Shumaker, D. K., Erdos, M. R., Eriksson, M., Goldman, A. E., Gordon, L. B., Gruenbaum, Y., Khuon, S., Mendez, M., Varga, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402943101 · Cited by 1,103
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
Shumaker, D. K., Dechat, T., Kohlmaier, A., Adam, S. A., Bozovsky, M. R., Erdos, M. R., Eriksson, M., Goldman, A. E., Khuon, S., Collins, F. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602569103 · Cited by 791
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Cited by
Actin Dynamics, Architecture, and Mechanics in Cell Motility
Blanchoin, L., Boujemaa-Paterski, R., Sykes, C., & Plastino, J. (2014) · Physiological Reviews · doi:10.1152/physrev.00018.2013 · Cited by 1,457
Investigating cell mechanics with atomic force microscopy
Haase, K., & Pelling, A. E. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.0970 · Cited by 396
Dechat, T., Adam, S. A., Taimen, P., Shimi, T., & Goldman, R. D. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000547 · Cited by 379
Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases
Kubben, N., & Misteli, T. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.68 · Cited by 320
The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate
(2018) · Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2018.02.002 · Cited by 286
Metadata
- Authors
- Dahl, K. N., Ribeiro, A. J. S., & Lammerding, J.
- Venue
- Circulation Research
- Published
- 2008-06-06
- Volume
- 102
- Issue
- 11
- Pages
- 1307-1318
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2132917470
- Cited by
- 708
- References
- 7
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- green
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- Dahl, K. N., Ribeiro, A. J. S., & Lammerding, J. (2008). Nuclear Shape, Mechanics, and Mechanotransduction. Circulation Research. https://doi.org/10.1161/circresaha.108.173989
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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