The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hemizygous Deficiency of Krüppel-Like Factor 2 Augments Experimental Atherosclerosis
Open accessAbstract
Krüppel-like factor (KLF)2 is a central regulator of endothelial and monocyte/macrophage gene expression and function in vitro. Although the composite effects of KLF2 in these 2 cell types predict that it likely inhibits vascular inflammation, the role of KLF2 in this process in vivo is uncharacterized. In this study, we provide evidence that hemizygous deficiency of KLF2 increased diet-induced atherosclerosis in apolipoprotein E–deficient mice. Our studies highlight an important role for KLF2 in primary macrophage foam cell formation via the potential regulation of the key lipid binding protein adipocyte protein 2/fatty acid–binding protein 4. These novel observations establish that KLF2 is an atheroprotective factor.
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Cites
Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237
Cited by
Recent insights into the cellular biology of atherosclerosis
Tabas, I., García-Cardeña, G., & Owens, G. K. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201412052 · Cited by 1,016
Mammalian Krüppel-Like Factors in Health and Diseases
McConnell, B. B., & Yang, V. W. (2010) · Physiological Reviews · doi:10.1152/physrev.00058.2009 · Cited by 1,018
Krüppel-like factor 4 regulates macrophage polarization
Liao, X., Sharma, N., Kapadia, F., Zhou, G., Lu, Y., Hong, H., Paruchuri, K., Mahabeleshwar, G. H., Dalmas, E., Venteclef, N., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45444 · Cited by 778
Self-citationVascular endothelium, hemodynamics, and the pathobiology of atherosclerosis
Gimbrone, M. A., & García-Cardeña, G. (2013) · Cardiovascular Pathology · doi:10.1016/j.carpath.2012.06.006 · Cited by 434
Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation
Wettschureck, N., Strilic, B., & Offermanns, S. (2019) · Physiological Reviews · doi:10.1152/physrev.00037.2018 · Cited by 286
Metadata
- Authors
- Atkins, G. B., Wang, Y., Mahabeleshwar, G. H., Shi, H., Gao, H., Kawanami, D., Natesan, V., Lin, Z., Simon, D. I., & Jain, M. K.
- Venue
- Circulation Research
- Published
- 2008-09-26
- Volume
- 103
- Issue
- 7
- Pages
- 690-693
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2140915672
- Cited by
- 180
- References
- 1
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Atkins, G. B., Wang, Y., Mahabeleshwar, G. H., Shi, H., Gao, H., Kawanami, D., Natesan, V., Lin, Z., Simon, D. I., & Jain, M. K. (2008). Hemizygous Deficiency of Krüppel-Like Factor 2 Augments Experimental Atherosclerosis. Circulation Research. https://doi.org/10.1161/circresaha.108.184663
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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