The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling
Open accessAbstract
Cyclic mechanical strain produced by pulsatile blood flow regulates the orientation of endothelial cells lining blood vessels and influences critical processes such as angiogenesis. Mechanical stimulation of stretch-activated calcium channels is known to mediate this reorientation response; however, the molecular basis remains unknown. Here, we show that cyclically stretching capillary endothelial cells adherent to flexible extracellular matrix substrates activates mechanosensitive TRPV4 (transient receptor potential vanilloid 4) ion channels that, in turn, stimulate phosphatidylinositol 3-kinase–dependent activation and binding of additional β1 integrin receptors, which promotes cytoskeletal remodeling and cell reorientation. Inhibition of integrin activation using blocking antibodies and knock down of TRPV4 channels using specific small interfering RNA suppress strain-induced capillary cell reorientation. Thus, mechanical forces that physically deform extracellular matrix may guide capillary cell reorientation through a strain-dependent “integrin-to-integrin” signaling mechanism mediated by force-induced activation of mechanically gated TRPV4 ion channels on the cell surface.
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Cites
Geometric Control of Cell Life and Death
Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M., & Ingber, D. E. (1997) · Science · doi:10.1126/science.276.5317.1425 · Cited by 4,657
Self-citationA mechanosensory complex that mediates the endothelial cell response to fluid shear stress
Tzima, E., Irani-Tehrani, M., Kiosses, W. B., Dejana, E., Schultz, D. A., Engelhardt, B., Cao, G., DeLisser, H., & Schwartz, M. A. (2005) · Nature · doi:10.1038/nature03952 · Cited by 1,711
Ausprunk, D. H., & Folkman, J. (1977) · Microvascular Research · doi:10.1016/0026-2862(77)90141-8 · Cited by 1,281
Heat-Evoked Activation of the Ion Channel, TRPV4
Güler, A. D., Lee, H., Iida, T., Shimizu, I., Tominaga, M., & Caterina, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06408.2002 · Cited by 1,031
Ingber, D. E., & Folkman, J. (1989) · The Journal of cell biology · doi:10.1083/jcb.109.1.317 · Cited by 868
Self-citationBlock of Stretch-Activated Ion Channels in Xenopus Oocytes by Gadolinium and Calcium Ions
Yang, X.-C., & Sachs, F. (1989) · Science · doi:10.1126/science.2466333 · Cited by 803
Long-term culture of capillary endothelial cells.
Folkman, J., Haudenschild, C. C., & Zetter, B. R. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.10.5217 · Cited by 772
TRPC1 forms the stretch-activated cation channel in vertebrate cells
Maroto, R., Raso, A., Wood, T. G., Kurosky, A., Martinac, B., & Hamill, O. P. (2005) · Nature Cell Biology · doi:10.1038/ncb1218 · Cited by 663
Ingber, D. E. (2002) · Circulation Research · doi:10.1161/01.res.0000039537.73816.e5 · Cited by 621
Self-citationActivation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives
Watanabe, H., Davis, J. B., Smart, D., Jerman, J. C., Smith, G. D., Hayes, P., Vriens, J., Cairns, W., Wissenbach, U., Prenen, J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200062200 · Cited by 605
Cited by
Reconstituting organ-level lung functions on a chip
Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250
Self-citationBhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305
Self-citationA Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice
Huh, D., Leslie, D. C., Matthews, B. D., Fraser, J. P., Jurek, S., Hamilton, G. A., Thorneloe, K. S., McAlexander, M. A., & Ingber, D. E. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004249 · Cited by 993
Self-citationMechanical control of tissue and organ development
Mammoto, T., & Ingber, D. E. (2010) · Development · doi:10.1242/dev.024166 · Cited by 850
Self-citationIntegrins and Extracellular Matrix in Mechanotransduction
Schwartz, M. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005066 · Cited by 662
Metadata
- Authors
- Thodeti, C. K., Matthews, B., Ravi, A., Mammoto, A., Ghosh, K., Bracha, A. L., & Ingber, D. E.
- Venue
- Circulation Research
- Published
- 2009-05-08
- Volume
- 104
- Issue
- 9
- Pages
- 1123-1130
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2138695033
- Cited by
- 375
- References
- 55
- FWCI
- 11.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling. https://app.cochat.ai/papers/10.1161/circresaha.108.192930
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- Thodeti, C. K., Matthews, B., Ravi, A., Mammoto, A., Ghosh, K., Bracha, A. L., & Ingber, D. E. (2009). TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling. Circulation Research. https://doi.org/10.1161/circresaha.108.192930
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