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Cited by 204Cardiovascular Disease and AdiposityCardiovascular Function and Risk FactorsAdipokines, Inflammation, and Metabolic Diseases

The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.

Adipocyte Fatty Acid–Binding Protein Suppresses Cardiomyocyte Contraction: A New Link Between Obesity and Heart Disease

Lamounier-Zepter, Valéria, Look, Christiane, Alvarez, Julio, Christ, Torsten, Ravens, Ursula, Schunck, Wolf-Hagen, Ehrhart-Bornstein, Monika, Bornstein, Stefan R., Morano, Ingo·2009·Circulation Research
DOI 10.1161/circresaha.109.200501
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Abstract

RATIONALE: Adipocyte fatty acid-binding protein (FABP4) is a member of the intracellular lipid-binding protein family and is predominantly expressed in adipose tissue. Emerging evidence suggests that FABP4 plays a role in some aspects of the metabolic syndrome including the development of type 2 diabetes and atherosclerosis. We have recently reported that secretory products from human adipocytes directly and acutely depressed cardiac contractile function. OBJECTIVE: The purpose of this study was to identify this adipocyte-derived cardiodepressant factor. METHODS AND RESULTS: Through mass spectrometry and immunoblotting, we have identified this cardiodepressant factor as FABP4. FABP4 represents 1.8% to 8.1% of total protein secreted by adipocytes in extracellular medium. FABP4 acutely depressed shortening amplitude as well as intracellular systolic peak Ca(2+) in a dose-dependent manner in isolated rat cardiomyocytes. Heart-specific FABP isoform (FABP3) revealed a similar cardiodepressant effect. The N-terminal amino acids 1 to 20 of FABP4 could be identified as the most effective cardiodepressive domain. We could exclude any effect of FABP4 on action potential duration and L-type Ca(2+) current, suggesting a reduced excitation-contraction gain caused by FABP4 as the main inhibitory mechanism. CONCLUSION: We conclude that the release of FABP4 from adipocytes may be involved in the development of cardiac contractile dysfunction of obese subjects.

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Crossref · 10.1161/circresaha.109.200501

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Metadata

Authors
Lamounier-Zepter, V., Look, C., Alvarez, J., Christ, T., Ravens, U., Schunck, W.-H., Ehrhart-Bornstein, M., Bornstein, S. R., & Morano, I.
Affiliations
  • From the Medical Clinic III (V.L.-Z., C.L., M.E.-B., S.R.B.), Dresden University of Technology, Germany; Institute of Cardiology (J.A.), La Habana, Cuba; Department of Pharmacology and Toxicology (T.C., U.R.), Dresden University of Technology, Germany; Max-Delbrueck-Center for Molecular Medicine (W.-H.S., I.M.), Berlin-Buch, Germany; and University Medicine Charité (I.M.), Berlin, Germany.
  • Max Delbrück Center (DE)
ORCID
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2009-08-14
Volume
105
Issue
4
Pages
326-334
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/circresaha.109.200501
OpenAlex
W2169507034
Cited by
203
References
32
Citations by year
2026: 2 · 2025: 12 · 2024: 15 · 2023: 8 · 2022: 5 · 2021: 13 · 2020: 11 · 2019: 12 · 2018: 7 · 2017: 13 · 2016: 16 · 2015: 14 · 2014: 16 · 2013: 21 · 2012: 15
FWCI
7.99
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
  • Site cant be reached (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords
adipocyte fatty acid-binding protein, FABP4, FABP3, cardiomyocyte contraction, cardiac contractile dysfunction, adipocyte secretome, excitation-contraction coupling, intracellular calcium, obesity, metabolic syndrome
MeSH terms
Action Potentials, Adult, Aged, Animals, Calcium, Cells, Cultured, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Myocardial Contraction, Obesity, Rats, Wistar, Adipocytes, Calcium Signaling, Metabolic Syndrome, Myocytes, Cardiac, Atherosclerosis, Fatty Acid-Binding Proteins, Rats

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