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The Cardiomyocyte Circadian Clock: Emerging Roles in Health and Disease

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Durgan, David J., Young, Martin E.·2010·Circulation Research

DOI 10.1161/circresaha.109.209957PMC PMC3223121

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Abstract

Abstract : Circadian misalignment has been implicated in the development of obesity, diabetes mellitus, and cardiovascular disease. Time-of-day–dependent synchronization of organisms with their environment is mediated by circadian clocks. This cell autonomous mechanism has been identified within all cardiovascular-relevant cell types, including cardiomyocytes. Recent molecular- and genetic-based studies suggest that the cardiomyocyte circadian clock influences multiple myocardial processes, including transcription, signaling, growth, metabolism, and contractile function. Following an appreciation of its physiological roles, the cardiomyocyte circadian clock has recently been linked to the pathogenesis of heart disease in response to adverse stresses, such as ischemia/reperfusion, in animal models. The purpose of this review is therefore to highlight recent advances regarding the roles of the cardiomyocyte circadian clock in both myocardial physiology and pathophysiology (ie, health and disease).

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Authors: Durgan, D. J., & Young, M. E.
Affiliations: University of Alabama at Birmingham (US)
ORCID: Durgan, David J.
Young, Martin E.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2010-03-05
Volume: 106
Issue: 4
Pages: 647-658
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.109.209957
PMC: PMC3223121
OpenAlex: W2055331130
Cited by: 277
References: 127
Citations by year: 2026: 17 · 2025: 15 · 2024: 8 · 2023: 11 · 2022: 11 · 2021: 17 · 2020: 18 · 2019: 22 · 2018: 9 · 2017: 24 · 2016: 15 · 2015: 20 · 2014: 26 · 2013: 22 · 2012: 21
FWCI: 2.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (HL-074259, R01HL074259)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords: circadian misalignment, clock genes, heart disease, ischemia-reperfusion injury, cardiomyocyte metabolism, contractile function, cardiovascular disease
MeSH terms: Animals, Biological Clocks, Cardiovascular Diseases, Circadian Rhythm, Energy Metabolism, Gene Expression Regulation, Heart Rate, Humans, Myocardial Contraction, Regeneration, Signal Transduction, Recovery of Function, Myocytes, Cardiac

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The Cardiomyocyte Circadian Clock: Emerging Roles in Health and Disease

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