The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
The Cardiomyocyte Circadian Clock: Emerging Roles in Health and Disease
Open accessAbstract
Abstract : Circadian misalignment has been implicated in the development of obesity, diabetes mellitus, and cardiovascular disease. Time-of-day–dependent synchronization of organisms with their environment is mediated by circadian clocks. This cell autonomous mechanism has been identified within all cardiovascular-relevant cell types, including cardiomyocytes. Recent molecular- and genetic-based studies suggest that the cardiomyocyte circadian clock influences multiple myocardial processes, including transcription, signaling, growth, metabolism, and contractile function. Following an appreciation of its physiological roles, the cardiomyocyte circadian clock has recently been linked to the pathogenesis of heart disease in response to adverse stresses, such as ischemia/reperfusion, in animal models. The purpose of this review is therefore to highlight recent advances regarding the roles of the cardiomyocyte circadian clock in both myocardial physiology and pathophysiology (ie, health and disease).
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“It has been suggested that that clock genes likely influence cardiac physiology and pathophysiology 19, 61.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [61]
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“Human and animal studies suggest that circadian clocks are not only important drivers of rhythms in CVD physiology and pathology but also for disease prevention and management 19, 61.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [61]
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Cited by
Sorted by citations
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
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Circadian rhythms and the molecular clock in cardiovascular biology and disease
Crnko, S., Du Pré, B. C., Sluijter, J. P. G., & Van Laake, L. W. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0167-4 · Cited by 499
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Metadata
- Authors
- Durgan, D. J., & Young, M. E.
- Affiliations
- University of Alabama at Birmingham (US)
- Venue
- Circulation Research
- Published
- 2010-03-05
- Volume
- 106
- Issue
- 4
- Pages
- 647-658
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC3223121
- OpenAlex
- W2055331130
- Cited by
- 277
- References
- 127
- Citations by year
- 2026: 17 · 2025: 15 · 2024: 8 · 2023: 11 · 2022: 11 · 2021: 17 · 2020: 18 · 2019: 22 · 2018: 9 · 2017: 24 · 2016: 15 · 2015: 20 · 2014: 26 · 2013: 22 · 2012: 21
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-074259, R01HL074259)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- circadian misalignment, clock genes, heart disease, ischemia-reperfusion injury, cardiomyocyte metabolism, contractile function, cardiovascular disease
- MeSH terms
- Animals, Biological Clocks, Cardiovascular Diseases, Circadian Rhythm, Energy Metabolism, Gene Expression Regulation, Heart Rate, Humans, Myocardial Contraction, Regeneration, Signal Transduction, Recovery of Function, Myocytes, Cardiac
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