Circadian rhythms and the molecular clock in cardiovascular biology and disease

Crnko, Sandra; Du Pré, Bastiaan C.; Sluijter, Joost P. G.; Van Laake, Linda W.

doi:10.1038/s41569-019-0167-4

Cited by 499Circadian rhythm and melatoninCardiac electrophysiology and arrhythmiasHeart Rate Variability and Autonomic Control

Circadian rhythms and the molecular clock in cardiovascular biology and disease

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Crnko, Sandra, Du Pré, Bastiaan C., Sluijter, Joost P. G., Van Laake, Linda W.·2019·Nature Reviews Cardiology

DOI 10.1038/s41569-019-0167-4

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Abstract

The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism - circadian rhythmicity - to anticipate the daily changes caused by this rotation. The molecular clocks that control circadian rhythms are being revealed as important regulators of physiology and disease. In humans, circadian rhythms have been studied extensively in the cardiovascular system. Many cardiovascular functions, such as endothelial function, thrombus formation, blood pressure and heart rate, are now known to be regulated by the circadian clock. Additionally, the onset of acute myocardial infarction, stroke, arrhythmias and other adverse cardiovascular events show circadian rhythmicity. In this Review, we summarize the role of the circadian clock in all major cardiovascular cell types and organs. Second, we discuss the role of circadian rhythms in cardiovascular physiology and disease. Finally, we postulate how circadian rhythms can serve as a therapeutic target by exploiting or altering molecular time to improve existing therapies and develop novel ones.

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Human and animal studies suggest that circadian clocks are important drivers of rhythms in CVD physiology and pathology and for disease prevention and management.
“Human and animal studies suggest that circadian clocks are not only important drivers of rhythms in CVD physiology and pathology but also for disease prevention and management 19, 61.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [19]
Clock genes likely influence cardiac physiology and pathophysiology.
“It has been suggested that that clock genes likely influence cardiac physiology and pathophysiology 19, 61.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [19]

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Authors: Crnko, S., Du Pré, B. C., Sluijter, J. P. G., & Van Laake, L. W.
Affiliations: Utrecht University (NL)
ORCID: Crnko, Sandra
Sluijter, Joost P. G.
Van Laake, Linda W.
Venue: Nature Reviews Cardiology
Publisher: Springer Science and Business Media LLC
Published: 2019-02-22
Volume: 16
Issue: 7
Pages: 437-447
ISSN: 1759-5002 (ISSN-L)
1759-5010
DOI: 10.1038/s41569-019-0167-4
OpenAlex: W2917295444
Cited by: 499
References: 175
Citations by year: 2026: 63 · 2025: 79 · 2024: 95 · 2023: 59 · 2022: 79 · 2021: 65 · 2020: 45 · 2019: 14
FWCI: 6.22
Type: journal article
Language: en
Open access: green
dspace.library.uu.nl
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: Nature Reviews Cardiology (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
Utrecht University Repository (Utrecht University) (submittedVersion)
Funders: Universiteit Utrecht
Nederlandse Federatie van Universitair Medische Centra
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords: circadian rhythm, circadian clock, cardiovascular physiology, cardiovascular disease, endothelial function, thrombosis, blood pressure, heart rate, myocardial infarction, stroke, cardiac arrhythmias, chronotherapy
MeSH terms: Animals, Biological Clocks, Blood Vessels, Cardiovascular Diseases, Circadian Rhythm, Humans, Chronobiology Disorders

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Circadian rhythms and the molecular clock in cardiovascular biology and disease

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