The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Short Communication: Vascular Smooth Muscle Cell Stiffness As a Mechanism for Increased Aortic Stiffness With Aging
Open accessAbstract
Rationale: Increased aortic stiffness, an important feature of many vascular diseases, eg, aging, hypertension, atherosclerosis, and aortic aneurysms, is assumed because of changes in extracellular matrix (ECM). Objective: We tested the hypothesis that the mechanisms also involve intrinsic stiffening of vascular smooth muscle cells (VSMCs). Methods and Results: Stiffness was measured in vitro both by atomic force microscopy (AFM) and in a reconstituted tissue model, using VSMCs from aorta of young versus old male monkeys ( Macaca fascicularis ) (n=7/group), where aortic stiffness increases by 200% in vivo. The apparent elastic modulus was increased ( P <0.05) in old (41.7±0.5 kPa) versus young (12.8±0.3 kPa) VSMCs but not after disassembly of the actin cytoskeleton with cytochalasin D. Stiffness of the VSMCs in the reconstituted tissue model was also higher ( P <0.05) in old (23.3±3.0 kPa) than in young (13.7±2.4 kPa). Conclusions: These data support the novel concept, not appreciated previously, that increased vascular stiffness with aging is attributable not only to changes in ECM but also to intrinsic changes in VSMCs.
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Cites
Integrins and the actin cytoskeleton
Delon, I., & Brown, N. H. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.12.013 · Cited by 249
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Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease
Lacolley, P., Regnault, V., Segers, P., & Laurent, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00003.2017 · Cited by 734
Cell mechanics: principles, practices, and prospects
Moeendarbary, E., & Harris, A. R. (2014) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1275 · Cited by 342
Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity
Weisbrod, R. M., Shiang, T., Al Sayah, L., Fry, J. L., Bajpai, S., Reinhart-King, C. A., Lob, H. E., Santhanam, L., Mitchell, G., Cohen, R. A., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01744 · Cited by 317
Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis
Wang, M., Kim, S. H., Monticone, R. E., & Lakatta, E. G. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.03618 · Cited by 207
Cellular Senescence and Vascular Disease: Novel Routes to Better Understanding and Therapy
Yin, H., & Pickering, J. G. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.02.051 · Cited by 82
Metadata
- Authors
- Qiu, H., Zhu, Y., Sun, Z., Trzeciakowski, J. P., Gansner, M., Depre, C., Resuello, R. R. G., Natividad, F. F., Hunter, W. C., Genin, G. M., Elson, E. L., Vatner, D. E., Meininger, G. A., & Vatner, S. F.
- Venue
- Circulation Research
- Published
- 2010-09-03
- Volume
- 107
- Issue
- 5
- Pages
- 615-619
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2126284874
- Cited by
- 340
- References
- 1
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Short Communication: Vascular Smooth Muscle Cell Stiffness As a Mechanism for Increased Aortic Stiffness With Aging. https://app.cochat.ai/papers/10.1161/circresaha.110.221846
- The paper
- Qiu, H., Zhu, Y., Sun, Z., Trzeciakowski, J. P., Gansner, M., Depre, C., Resuello, R. R. G., Natividad, F. F., Hunter, W. C., Genin, G. M., Elson, E. L., Vatner, D. E., Meininger, G. A., & Vatner, S. F. (2010). Short Communication: Vascular Smooth Muscle Cell Stiffness As a Mechanism for Increased Aortic Stiffness With Aging. Circulation Research. https://doi.org/10.1161/circresaha.110.221846
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
