Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis
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Plaque destabilization through cap thinning is promoted by various MMPs secreted as part of the SASP of senescent VSMCs, monocytes, macrophages, and foam cells.
“Plaque destabilization through cap thinning is promoted by various MMPs,49 such as MMP-1, -2, -3, -7, -8, -9, -10, -12, -13, and -14,45,49,51 which are secreted as part of the SASP of senescent VSMCs, monocytes, macrophages, and foam cells.”
From Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis (2020) · cites this paper as [49]
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- Authors
- Wang, M., Kim, S. H., Monticone, R. E., & Lakatta, E. G.
- Affiliations
- National Institutes of Health (US)
- Venue
- Hypertension
- Published
- 2015-04
- Volume
- 65
- Issue
- 4
- Pages
- 698-703
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC4359070
- OpenAlex
- W2147065016
- Cited by
- 207
- References
- 74
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 19 · 2023: 12 · 2022: 15 · 2021: 17 · 2020: 21 · 2019: 21 · 2018: 22 · 2017: 22 · 2016: 17 · 2015: 4
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (ZIAAG000239)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- matrix metalloproteinases, arterial remodeling, aging, atherosclerosis, vascular remodeling
- MeSH terms
- Aging, Animals, Arteries, Humans, Hypertension, Disease Progression, Matrix Metalloproteinases, Atherosclerosis, Vascular Remodeling
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