The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.
Oxidative Stress and Diabetic Complications
Open accessAbstract
Oxidative stress plays a pivotal role in the development of diabetes complications, both microvascular and cardiovascular. The metabolic abnormalities of diabetes cause mitochondrial superoxide overproduction in endothelial cells of both large and small vessels, as well as in the myocardium. This increased superoxide production causes the activation of 5 major pathways involved in the pathogenesis of complications: polyol pathway flux, increased formation of AGEs (advanced glycation end products), increased expression of the receptor for AGEs and its activating ligands, activation of protein kinase C isoforms, and overactivity of the hexosamine pathway. It also directly inactivates 2 critical antiatherosclerotic enzymes, endothelial nitric oxide synthase and prostacyclin synthase. Through these pathways, increased intracellular reactive oxygen species (ROS) cause defective angiogenesis in response to ischemia, activate a number of proinflammatory pathways, and cause long-lasting epigenetic changes that drive persistent expression of proinflammatory genes after glycemia is normalized (“hyperglycemic memory”). Atherosclerosis and cardiomyopathy in type 2 diabetes are caused in part by pathway-selective insulin resistance, which increases mitochondrial ROS production from free fatty acids and by inactivation of antiatherosclerosis enzymes by ROS. Overexpression of superoxide dismutase in transgenic diabetic mice prevents diabetic retinopathy, nephropathy, and cardiomyopathy. The aim of this review is to highlight advances in understanding the role of metabolite-generated ROS in the development of diabetic complications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Chronic overproduction of ROS increases oxidative stress, damages DNA, increases apoptosis, and triggers inflammation, which is a key feature in T2DM and metabolic syndrome (42).”
From TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet–Induced Insulin Resistance in Skeletal Muscle (2019) · cites this paper as [42]
Experimental — accuracy not yet measuredIn the citing paper
“Taken together, our data suggest significant molecular and metabolic perturbations between NHOs and PGDHOs consistent with previous studies on PGD suggesting increased oxidative stress, cardiomyopathy, and altered lipid profiles48–50”
From Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease (2021) · cites this paper as [49]
In the citing paper
“Hyperglycemia and PKC activation-induced ROS production result in inflammatory changes in the vascular endothelium including monocytes adhesion, formation of foam cells, and activation of major biochemical paths including polyol pathway flux and increased formation of advanced glycation end products, further contributing to the development of atherosclerosis.40”
From Glycemic variability and cardiovascular disease in patients with type 2 diabetes (2021) · cites this paper as [40]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
Xie, Z., Zhang, J., Wu, J., Viollet, B., & Zou, M. (2008) · Diabetes · doi:10.2337/db08-0610 · Cited by 165
RetractedReddy, M. A., Villeneuve, L. M., Wang, M., Lanting, L. L., & Natarajan, R. D. (2008) · Circulation Research · doi:10.1161/circresaha.108.175190 · Cited by 83
Retracted(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667
Turner, R. C., Fox, C., Matthews, McElroy, H. H., Cull, C. A., Holman, R. R., Neil, P., Hadden, D. R., Wright, D., Manley, E., et al. (1998) · The Lancet · Cited by 8,419
10-year follow-up of intensive glucose control in type 2 diabetes
Holman, R. R., Paul, S. K., Bethel, M. A., Matthews, D. R., & Neil, H. A. W. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0806470 · Cited by 7,751
Haffner, S. M., Lehto, S., Rönnemaa, T., Pyörälä, K., & Laakso, M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807233390404 · Cited by 7,000
The Pathobiology of Diabetic Complications
Brownlee, M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1615 · Cited by 5,339
Self-citationIntensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
(2005) · New England Journal of Medicine · doi:10.1056/nejmoa052187 · Cited by 5,138
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- National Diabetes Data Group. Diabetes in America. 2nd ed. Bethesda, Md: National Institute of Diabetes and Digestive and Kidney Diseases, NIH; 1995.
Cited by
Sorted by citations
Items 201–300 of 1,018
The endothelium: influencing vascular smooth muscle in many ways
Triggle, C. R., Samuel, S. M., Ravishankar, S., Marei, I., Arunachalam, G., & Ding, H. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-073 · Cited by 229
Roles of Hydrogen Sulfide in the Pathogenesis of Diabetes Mellitus and Its Complications
Szabó, C. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4451 · Cited by 216
Zhao, X., Liu, Y., Ma, R., Chen, J., Qiu, J., Du, S., Li, C., Wu, Z., Yang, X., Chen, Z., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c24569 · Cited by 216
Packer, M. (2020) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2020.04.016 · Cited by 218
Natural Phyto-Bioactive Compounds for the Treatment of Type 2 Diabetes: Inflammation as a Target
Gothai, S., Ganesan, P., Park, S., Fakurazi, S., Choi, D., & Arulselvan, P. (2016) · Nutrients · doi:10.3390/nu8080461 · Cited by 226
Fibroblast Growth Factor in Diabetic Foot Ulcer: Progress and Therapeutic Prospects
Liu, Y., Liu, Y.-Q., Deng, J., Li, W., & Nie, X.-Q. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.744868 · Cited by 196
Zhang, Z., Huang, Q., Zhao, D., Lian, F., Li, X., & Qi, W. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1112363 · Cited by 236
Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing
Ezhilarasu, H., Dinesh, V., Dheen, S. T., Bay, B., & Srinivasan, D. K. (2020) · Nanomaterials · doi:10.3390/nano10061234 · Cited by 218
Yue, T., Shi, Y., Luo, S., Weng, J., Wu, Y., & Zheng, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1055087 · Cited by 230
How Effective Are Antioxidant Supplements in Obesity and Diabetes?
Abdali, D., Samson, S. E., & Grover, A. K. (2015) · Medical Principles and Practice · doi:10.1159/000375305 · Cited by 214
Martinez‐Outschoorn, U., Sotgia, F., & Lisanti, M. P. (2014) · Seminars in Oncology · doi:10.1053/j.seminoncol.2014.03.002 · Cited by 211
In Vitro/In Vivo Toxicity Evaluation and Quantification of Iron Oxide Nanoparticles
Patil, U., Adireddy, S., Jaiswal, A. R., Mandava, S. H., Lee, B. G., & Chrisey, D. B. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161024417 · Cited by 209
Mortuza, R., Chen, S., Feng, B., Sen, S., & Chakrabarti, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054514 · Cited by 208
OxInflammation: From Subclinical Condition to Pathological Biomarker
Valacchi, G., Virgili, F., Cervellati, C., & Pecorelli, A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00858 · Cited by 212
Ceriello, A., Novials, A., Ortega, E., Canivell, S., La Sala, L., Pujadas, G., Esposito, K., Giugliano, D., & Genovese, S. (2013) · Diabetes Care · doi:10.2337/dc12-2469 · Cited by 204
Fang, W., Wang, C., He, Y., Zhou, Y., Peng, X., & Liu, S. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.50 · Cited by 207
Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
Matzinger, M., Fischhuber, K., & Heiß, E. H. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.12.015 · Cited by 208
Modulation of Glucose Transporter Protein by Dietary Flavonoids in Type 2 Diabetes Mellitus
Hajiaghaalipour, F., Khalilpourfarshbafi, M., & Arya, A. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.11241 · Cited by 215
Papatheodorou, K., Banach, M., EDMONDS, M. E., Παπάνας, Ν., & Papazoglou, D. (2015) · Journal of Diabetes Research · doi:10.1155/2015/189525 · Cited by 203
Antioxidant Activity, Metabolism, and Bioavailability of Polyphenols in the Diet of Animals
Bešlo, D., Golubić, N., Rastija, V., Agić, D., Karnaš, M., Šubarić, D., & Lučić, B. (2023) · Antioxidants · doi:10.3390/antiox12061141 · Cited by 226
Devi, T. S., Lee, I., Hüttemann, M., Kumar, A., Nantwi, K. D., & Singh, L. P. (2012) · Experimental Diabetes Research · doi:10.1155/2012/438238 · Cited by 203
Goveia, J., Stapor, P. C., & Carmeliet, P. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404156 · Cited by 203
Ohta, S. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.05.006 · Cited by 202
Paul, S., Ali, A., & Katare, R. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107613 · Cited by 215
Khan, S. R. (2012) · Urological Research · doi:10.1007/s00240-011-0448-9 · Cited by 202
Diabetic retinopathy: a complex pathophysiology requiring novel therapeutic strategies
Whitehead, M. A., Wickremasinghe, S., Osborne, A., van Wijngaarden, P., & Martin, K. R. G. (2018) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2018.1545836 · Cited by 209
Diabetic Foot Ulcers: Pathophysiology, Immune Dysregulation, and Emerging Therapeutic Strategies
Dawi, J., Tumanyan, K., Tomas, K., Misakyan, Y., Gargaloyan, A., Gonzalez, E., Hammi, M., Tomas, S., & Venketaraman, V. (2025) · Biomedicines · doi:10.3390/biomedicines13051076 · Cited by 225
Diabetic nephropathy and antioxidants
Tavafi, M. (2013) · Journal of Nephropathology · doi:10.5812/nephropathol.9093 · Cited by 195
Thrombosis and Vascular Inflammation in Diabetes: Mechanisms and Potential Therapeutic Targets
Pechlivani, N., & Ajjan, R. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00001 · Cited by 204
A bidirectional relationship between sleep and oxidative stress in Drosophila
Hill, V. M., O'Connor, R. M., Sissoko, G. B., Irobunda, I., Leong, S., Canman, J. C., Stavropoulos, N., & Shirasu‐Hiza, M. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005206 · Cited by 200
Ceriello, A., Bortolotti, N., Motz, E., Pieri, C., Marra, M., Tonutti, L., Lizzio, S., Feletto, F., Catone, B., & Taboga, C. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90237-8 · Cited by 197
Oxidative Stress and MicroRNAs in Vascular Diseases
Magenta, A., Greco, S., Gaetano, C., & Martelli, F. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140917319 · Cited by 198
Gu, J., Cheng, Y., Wu, H., Kong, L., Wang, S., Xu, Z., Zhang, Z., Tan, Y., Keller, B. B., Zhou, H., et al. (2016) · Diabetes · doi:10.2337/db15-1274 · Cited by 196
Hu, R., Wang, M., Ni, S.-H., Wang, M., Liu, L., You, H., Wu, X., Wang, Y., Lu, L., & Wei, L. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172797 · Cited by 199
Circulating Oxidative Stress Biomarkers in Clinical Studies on Type 2 Diabetes and Its Complications
Bigagli, E., & Lodovici, M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5953685 · Cited by 208
Journal of Pharmaceutical and Biomedical Sciences
(2016) · Journal of Pharmaceutical and Biomedical Sciences · doi:10.20936/jpbms · Cited by 193
Mitochondrial Hormesis and Diabetic Complications
Sharma, K. (2015) · Diabetes · doi:10.2337/db14-0874 · Cited by 194
Mitochondrial dysfunction and complications associated with diabetes
Blake, R., & Trounce, I. A. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.11.007 · Cited by 190
Al‐Numair, K. S., Govindasamy, C., Veeramani, C., & Alsaif, M. A. (2014) · Redox Report · doi:10.1179/1351000214y.0000000117 · Cited by 198
Bagul, P. K., Middela, H., Mattapally, S., Padiya, R., Bastia, T., Madhusudana, K., Reddy, B. R., Chakravarty, S., & Banerjee, S. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.05.003 · Cited by 193
Endocrine Disruptors Leading to Obesity and Related Diseases
Petrakis, D., Vassilopoulou, L., Mamoulakis, C., Psycharakis, C., Anifantaki, A., Sifakis, S., Docea, A. O., Tsiaoussis, J., Makrigiannakis, A., & Tsatsakis, A. M. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14101282 · Cited by 194
Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress
Ponugoti, B., Dong, G., & Graves, D. T. (2012) · Experimental Diabetes Research · doi:10.1155/2012/939751 · Cited by 196
Schmatz, R., Pereira, L. B., Stefanello, N., Mazzanti, C. M. D. A., Spanevello, R. M., Gutierres, J. M., Bagatini, M. D., Martins, C. C., Abdalla, F. H., Serres, J. D. D. S., et al. (2011) · Biochimie · doi:10.1016/j.biochi.2011.08.005 · Cited by 192
Long noncoding RNA-MEG3 is involved in diabetes mellitus-related microvascular dysfunction
Qiu, G.-Z., Tian, W., Fu, H., Li, C.-P., & Liu, B. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.01.164 · Cited by 191
Buranasin, P., Mizutani, K., Iwasaki, K., Mahasarakham, C. P. N., Kido, D., Takeda, K., & Izumi, Y. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201855 · Cited by 191
Secomandi, L., Borghesan, M., Velarde, M., & Demaria, M. (2022) · Human Reproduction Update · doi:10.1093/humupd/dmab038 · Cited by 208
Diabetes Mellitus and Heart Failure
Lehrke, M., & Marx, N. (2017) · The American Journal of Medicine · doi:10.1016/j.amjmed.2017.04.010 · Cited by 196
Askari, H., Rajani, S. F., Poorebrahim, M., Haghi‐Aminjan, H., Raeis-Abdollahi, E., & Abdollahi, M. R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.012 · Cited by 191
Jiang, S., Young, J. L., Wang, K., Qian, Y., & Cai, L. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11175 · Cited by 206
Molecular Mechanisms of Mitochondrial Quality Control in Ischemic Cardiomyopathy
Chang, X., Liu, R., Li, R., Peng, Y., Zhu, P., & Zhou, H. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.76223 · Cited by 196
Antioxidant peptides, the guardian of life from oxidative stress
Zhu, Y., Wang, K., Jia, X., Fu, C., Yu, H., & Wang, Y. (2023) · Medicinal Research Reviews · doi:10.1002/med.21986 · Cited by 198
Costantino, S., Paneni, F., Battista, R., Castello, L., Capretti, G., Chiandotto, S., Tanese, L., Russo, G., Pitocco, D., Lanza, G. A., et al. (2017) · Diabetes · doi:10.2337/db17-0294 · Cited by 188
Joyal, J., Gantner, M. L., & Smith, L. E. H. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.11.002 · Cited by 193
DiLoreto, R., & Murphy, C. T. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-06-1084 · Cited by 192
Oxidative Stress‐Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy
Li, C., Miao, X., Li, F., Wang, S., Liu, Q., Wang, Y., & Sun, J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9702820 · Cited by 191
Understanding Diabetic Neuropathy: Focus on Oxidative Stress
Pang, L., Lian, X., Liu, H., Zhang, Y., Li, Q., Cai, Y., Ma, H., & Yu, X. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9524635 · Cited by 184
Inflammation and diabetic retinal microvascular complications
Zhang, W., Liu, H., Al‐Shabrawey, M., Caldwell, R. W., & Caldwell, R. B. (2011) · Journal of Cardiovascular Disease Research · doi:10.4103/0975-3583.83035 · Cited by 184
Beneficial roles of honey polyphenols against some human degenerative diseases: A review
Hossen, M. S., Ali, M. Y., Jahurul, M. H. A., Abdel‐Daim, M. M., Gan, S. H., & Khalil, M. I. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.07.002 · Cited by 185
Knockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic Mice
Giacco, F., Du, X., D’Agati, V. D., Milne, R. W., Sui, G., Geoffrion, M., & Brownlee, M. (2013) · Diabetes · doi:10.2337/db13-0316 · Cited by 184
Self-citationThe gut–renal axis: do incretin-based agents confer renoprotection in diabetes?
Muskiet, M. H. A., Smits, M. M., Morsink, L. M., & Diamant, M. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.272 · Cited by 187
Bonner, R., Albajrami, O., Hudspeth, J. C., & Upadhyay, A. (2020) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2020.08.004 · Cited by 200
The Investigation of the Oxidative Stress-Related Parameters in Type 2 Diabetes Mellitus
Aouacheri, O., Saka, S., Krim, M., Messaadia, A., & Maidi, I. (2014) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2014.03.002 · Cited by 180
A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes
Taylor, J. J., Preshaw, P. M., & Lalla, E. (2013) · Journal of Periodontology · doi:10.1902/jop.2013.134005 · Cited by 183
Wang, D., Luo, P., Wang, Y., Li, W., Wang, C., Sun, D., Zhang, R., Su, T., Ma, X., Zeng, C., et al. (2013) · Diabetes · doi:10.2337/db12-1025 · Cited by 179
Tsuchiya, K., Tanaka, J., Yu, S., Welch, C. L., DePinho, R. A., Tabas, I. A., Tall, A. R., Goldberg, I. J., & Accili, D. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.018 · Cited by 178
Lutchmansingh, F., Hsu, J. W.-C., Bennett, F. I., Badaloo, A. V., McFarlane‐Anderson, N., Gordon-Strachan, G. M., Wright-Pascoe, R. A., Jahoor, F., & Boyne, M. S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198626 · Cited by 187
Physiological and Pathological Roles of Aldose Reductase
Singh, M., Kapoor, A., & Bhatnagar, A. (2021) · Metabolites · doi:10.3390/metabo11100655 · Cited by 197
Gülçın, İ., Kaya, R., Gören, A. C., Akıncıoğlu, H., Topal, M., Bingöl, Z., Çakmak, K. C., Sarıkaya, S. B. Ö., Durmaz, L., & Alwasel, S. H. (2019) · International Journal of Food Properties · doi:10.1080/10942912.2019.1656232 · Cited by 178
Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes
Funk, S. D., Yurdagul, A., & Orr, A. W. (2012) · International Journal of Vascular Medicine · doi:10.1155/2012/569654 · Cited by 176
Advances in our understanding of diabetic retinopathy
Stitt, A. W., Lois, N., Medina, R. J., Adamson, P., & Curtis, T. M. (2013) · Clinical Science · doi:10.1042/cs20120588 · Cited by 182
Diabetes mellitus and stroke: A clinical update
Tun, N. N., Arunagirinathan, G., Munshi, S. K., & Pappachan, J. M. (2017) · World Journal of Diabetes · doi:10.4239/wjd.v8.i6.235 · Cited by 177
Extraglycemic Effects of SGLT2 Inhibitors: A Review of the Evidence
Bonora, B. M., Avogaro, A., & Fadini, G. P. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s233538 · Cited by 199
Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy
Byrne, N. J., Rajasekaran, N. S., Abel, E. D., & Bugger, H. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.046 · Cited by 179
Postbiotics as potential new therapeutic agents for metabolic disorders management
Bourebaba, Y., Marycz, K., Mularczyk, M., & Bourebaba, L. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113138 · Cited by 191
Paneni, F., Costantino, S., Battista, R., Castello, L., Capretti, G., Chiandotto, S., Scavone, G., Villano, A., Pitocco, D., Lanza, G. A., et al. (2014) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.114.000671 · Cited by 177
The Role of Zinc and Copper in Insulin Resistance and Diabetes Mellitus
Bjørklund, G., Dadar, M., Pivina, L. M., Doşa, M. D., Semenova, Y. M., & Aaseth, J. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190902122155 · Cited by 178
Eryptosis and oxidative damage in type 2 diabetic mellitus patients with chronic kidney disease
Calderón-Salinas, J. V., Muñoz-Reyes, E. G., Guerrero-Romero, J. F., Rodríguez‐Morán, M., Bracho-Riquelme, R. L., Carrera-Gracia, M., & Escorza, M. A. Q. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0887-1 · Cited by 174
Morris, D., Khurasany, M., Nguyen, T., Kim, J., Guilford, F. T., Mehta, R. J., Gray, D., Saviola, B., & Venketaraman, V. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.10.012 · Cited by 178
Antihyperglycemic Effect ofGinkgo bilobaExtract in Streptozotocin-Induced Diabetes in Rats
Cheng, D., Liang, B., & Li, Y. (2012) · BioMed Research International · doi:10.1155/2013/162724 · Cited by 173
Catalase Deficiency Accelerates Diabetic Renal Injury Through Peroxisomal Dysfunction
Hwang, I., Lee, J., Huh, J. Y., Park, J., Lee, H. B., Ho, Y.-S., & Ha, H. (2012) · Diabetes · doi:10.2337/db11-0584 · Cited by 173
Chattopadhyay, M., Khemka, V., Chatterjee, G., Ganguly, A., Mukhopadhyay, S., & Chakrabarti, S. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2236-7 · Cited by 143
Regulation of Inflammatory Phenotype in Macrophages by a Diabetes-Induced Long Noncoding RNA
Reddy, M. A., Chen, Z., Park, J. T., Wang, M., Lanting, L. L., Zhang, Q., Bhatt, K. S., Leung, A., Wu, X., Putta, S., et al. (2014) · Diabetes · doi:10.2337/db14-0298 · Cited by 172
Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy
Ola, M. S., Nawaz, M. I., Siddiquei, M. M., Al-Amro, S. A., & El‐Asrar, A. M. A. (2012) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2011.11.004 · Cited by 176
Regulation of eNOS Enzyme Activity by Posttranslational Modification
Heiß, E. H., & Dirsch, V. M. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660745 · Cited by 171
m 6 A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin
Liang, D., Lin, W., Ren, M., Qiu, J., Yang, C., Wang, X., Li, N., Zeng, T., Sun, K., You, L., et al. (2021) · Autophagy · doi:10.1080/15548627.2021.1974175 · Cited by 174
Role of free radical in atherosclerosis, diabetes and dyslipidaemia: larger‐than‐life
Singh, R., Devi, S., & Gollen, R. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2558 · Cited by 180
Diabetic retinopathy: Breaking the barrier
Eshaq, R. S., Aldalati, A. M. Z., Alexander, J. S., & Harris, N. R. (2017) · Pathophysiology · doi:10.1016/j.pathophys.2017.07.001 · Cited by 175
Pathophysiology of Coronary Microvascular Dysfunction
Crea, F., Montone, R. A., & Rinaldi, R. (2021) · Circulation Journal · doi:10.1253/circj.cj-21-0848 · Cited by 169
Symbiotic Algae–Bacteria Dressing for Producing Hydrogen to Accelerate Diabetic Wound Healing
Chen, H., Guo, Y., Zhang, Z., Mao, W., Shen, C., Xiong, W. H., Yao, Y., Zhao, X., Hu, Y., Zou, Z., et al. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c03693 · Cited by 169
Singh, A. P., Shadangi, S., Gupta, P. K., & Rana, S. (2025) · Comprehensive physiology · doi:10.1002/cph4.70003 · Cited by 201
Honey - A Novel Antidiabetic Agent
Erejuwa, O. O., Sulaiman, S. A., & Wahab, M. S. A. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.3697 · Cited by 173
Timar, B., Timar, R. Z., Gaiţă, L., Oancea, C. I., Levai, C., & Lungeanu, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154654 · Cited by 168
González, N., Prieto, I., del Puerto‐Nevado, L., Portal‐Núñez, S., Ardura, J. A., Cortón, M., Fernández‐Fernández, B., Aguilera, Ó., Gómez‐Guerrero, C., Mas, S., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14472 · Cited by 177
Tanaka, S., Sugiura, Y., Saito, H., Sugahara, M., Higashijima, Y., Yamaguchi, J., Inagi, R., Suematsu, M., Nangaku, M., & Tanaka, T. (2018) · Kidney International · doi:10.1016/j.kint.2018.04.025 · Cited by 166
Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies
Bule, M. H., Abdurahman, A. A., Nikfar, S., Abdollahi, M. R., & Amini, M. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.01.037 · Cited by 176
Oxidative Stress and Lectin-Like Ox-LDL-Receptor LOX-1 in Atherogenesis and Tumorigenesis
Lü, J., Mitra, S., Wang, X., Khaidakov, M., & Mehta, J. L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3792 · Cited by 168
Opuntia spp.: Characterization and Benefits in Chronic Diseases
Díaz, M. D. S. S., de la Rosa, A. P. B., Héliès‐Toussaint, C., Guéraud, F., & Nègre‐Salvayre, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8634249 · Cited by 166
Razmpoosh, E., Javadi, A., Ejtahed, H., Mirmiran, P., Javadi, M., & Yousefinejad, A. (2018) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2018.08.008 · Cited by 172
Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases
da Costa, R. M., Rodrigues, D., Pereira, C. A., da Silva, J. F., Alves, J. V., Lobato, N. S., & Tostes, R. C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00382 · Cited by 168
Módis, K., Bos, E. M., Calzia, E., van Goor, H., Coletta, C., Papapetropoulos, A., Hellmich, M. R., Radermacher, P., Bouillaud, F., & Szabó, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12368 · Cited by 163
Metadata
- Authors
- Giacco, F., & Brownlee, M.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Brownlee, Michael
- Venue
- Circulation Research
- Published
- 2010-10-29
- Volume
- 107
- Issue
- 9
- Pages
- 1058-1070
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC2996922
- OpenAlex
- W2105731956
- Cited by
- 5,461
- References
- 152
- Citations by year
- 2026: 305 · 2025: 331 · 2024: 416 · 2023: 448 · 2022: 478 · 2021: 435 · 2020: 411 · 2019: 349 · 2018: 370 · 2017: 367 · 2016: 338 · 2015: 318 · 2014: 327 · 2013: 260 · 2012: 203
- FWCI
- 17.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK074153, R01-DK07453, P60DK020541)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- oxidative stress, diabetes complications, superoxide, reactive oxygen species, mitochondrial dysfunction, polyol pathway, advanced glycation end products, AGE receptor, protein kinase C, hexosamine biosynthetic pathway, endothelial nitric oxide synthase, prostacyclin synthase, angiogenesis, inflammation, epigenetic modifications, atherosclerosis, diabetic cardiomyopathy, type 2 diabetes, insulin resistance, superoxide dismutase, diabetic retinopathy, diabetic nephropathy
- MeSH terms
- Animals, Humans, Hyperglycemia, Cardiomyopathies, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Diabetes Complications, Atherosclerosis, Microvessels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review