The DOI matches its Crossref record; 220 of the 220 references it cites were found in a registry or an index.
Assessing Cell and Organ Senescence Biomarkers
Open accessAbstract
A major goal in cancer and aging research is to discriminate the biochemical modifications that happen locally that could account for the healthiness or malignancy of tissues. Senescence is one general antiproliferative cellular process that acts as a strong barrier for cancer progression, playing a crucial role in aging. Here, we focus on the current methods to assess cellular senescence, discriminating the advantages and disadvantages of several senescence biomarkers.
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“Expression of p16INK4A and p21CIP1 were both used as markers of senescent cells, as was SAβgal activity [50,51].”
In the citing paper
“Senescent cells are recognized by specific markers, including cyclin-dependent kinase inhibitor 2A (commonly known as p16INK4A) and increased lysosome β-galactosidase activity, although these markers are neither fully sensitive nor specific and, despite intense research, no gold-standard biomarker of cellular senescence has been established90.”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [90]
In the citing paper
“To identify senescent cells in histological section by immunocytochemistry or immunofluorescence, the most common markers used are senescence associated galactosidase (SA gal) expression, the cyclin inhibitor p16/INK or the DNA damage response protein H2AX however these techniques are rarely combined [55].”
From Senescence of T Lymphocytes: Implications for Enhancing Human Immunity (2016) · cites this paper as [55]
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Items 201–220 of 220
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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690
Hickson, L. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.069 · Cited by 1,383
Senescence of T Lymphocytes: Implications for Enhancing Human Immunity
Akbar, A. N., Henson, S. M., & Lanna, A. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.09.002 · Cited by 285
Aging of the cells: Insight into cellular senescence and detection Methods.
Mohamad Kamal, N. S., Safuan, S., Shamsuddin, S., & Foroozandeh, P. (2020) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2020.151108 · Cited by 287
Techniques to induce and quantify cellular senescence
Noren Hooten, N., & Evans, M. K. (2017) · Journal of Visualized Experiments · doi:10.3791/55533 · Cited by 178
Metadata
- Authors
- de Jesus, B. B., & Blasco, M. A.
- Affiliations
- From the Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain.
- Venue
- Circulation Research
- Published
- 2012-06-22
- Volume
- 111
- Issue
- 1
- Pages
- 97-109
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC4824275
- OpenAlex
- W2097942030
- Semantic Scholar
- 24ec5011ed34912ebf7a84c15c5320f843b3b0be
- Cited by
- 187
- References
- 220
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 20 · 2023: 11 · 2022: 7 · 2021: 20 · 2020: 17 · 2019: 12 · 2018: 17 · 2017: 17 · 2016: 19 · 2015: 8 · 2014: 6 · 2013: 9 · 2012: 2
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, senescence biomarkers, aging, tumor progression
- MeSH terms
- Aging, Animals, Genetic Markers, Genotype, Humans, Oncogenes, Phenotype, Biomarkers, Telomere, Cellular Senescence, Telomere Shortening
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