Assessing Cell and Organ Senescence Biomarkers

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Oxidative stress shortens telomeres

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

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Switching and Signaling at the Telomere

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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

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Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

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How Shelterin Protects Mammalian Telomeres

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TRF2 Protects Human Telomeres from End-to-End Fusions

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Cellular senescence in cancer and aging.

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The RB and p53 pathways in cancer

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

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Telomeres and human disease: ageing, cancer and beyond

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Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

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DNA Damage Foci at Dysfunctional Telomeres

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Telomere states and cell fates

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The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

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Telomere dysfunction induces metabolic and mitochondrial compromise

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Heart regeneration

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The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

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Senescence in tumours: evidence from mice and humans

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Cellular Senescence in Aging Primates

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p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2

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Autophagy mediates the mitotic senescence transition

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p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

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Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

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The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

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Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

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Telomerase modulates Wnt signalling by association with target gene chromatin

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DNA damage response and cellular senescence in tissues of aging mice

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De novo cardiomyocytes from within the activated adult heart after injury

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Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

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Senescent cells as a source of inflammatory factors for tumor progression

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A novel role for high-mobility group A proteins in cellular senescence and heterochromatin formation

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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

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The epigenetic regulation of mammalian telomeres

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Targeted disruption of the three Rb-related genes leads to loss of G 1 control and immortalization

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Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

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Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

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Cardiac Stem Cell and Myocyte Aging, Heart Failure, and Insulin-Like Growth Factor-1 Overexpression

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PML is induced by oncogenic ras and promotes premature senescence

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DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

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Methods to Detect Biomarkers of Cellular Senescence

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The Mechanisms of PML-Nuclear Body Formation

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