Cited by 189Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressCardiac Fibrosis and Remodeling

The DOI matches its Crossref record; 24 of the 25 references it cites were found in a registry or an index.

Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy

Open access

Matsushima, Shouji, Kuroda, Junya, Ago, Tetsuro, Zhai, Peiyong, Park, Ji Yeon, Xie, Lai-Hua, Tian, Bin, Sadoshima, Junichi·2013·Circulation Research

DOI 10.1161/circresaha.112.279760PMC PMC3574183

Open this paper in CoChat — free account Open PDF

Abstract

Rationale: Oxidation of cysteine residues in class II histone deacetylases (HDACs), including HDAC4, causes nuclear exit, thereby inducing cardiac hypertrophy. The cellular source of reactive oxygen species responsible for oxidation of HDAC4 remains unknown. Objective: We investigated whether nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4), a major nicotinamide adenine dinucleotide phosphate oxidase, mediates cysteine oxidation of HDAC4. Methods and Results: Phenylephrine (100 μmol/L), an α1 adrenergic agonist, induced upregulation of Nox4 (1.5-fold; P <0.05) within 5 minutes, accompanied by increases in O 2 − (3.5-fold; P <0.01) from the nuclear membrane and nuclear exit of HDAC4 in cardiomyocytes. Knockdown of Nox4, but not Nox2, attenuated O 2 − production in the nucleus and prevented phenylephrine-induced oxidation and nuclear exit of HDAC4. After continuous infusion of phenylephrine (20 mg/kg per day) for 14 days, wild-type and cardiac-specific Nox4 knockout mice exhibited similar aortic pressures. Left ventricular weight/tibial length (5.7±0.2 versus 6.4±0.2 mg/mm; P <0.05) and cardiomyocytes cross-sectional area (223±13 versus 258±12 μm 2 ; P <0.05) were significantly smaller in cardiac-specific Nox4 knockout than in wild-type mice. Nuclear O 2 − production in the heart was significantly lower in cardiac-specific Nox4 knockout than in wild-type mice (4116±314 versus 7057±1710 relative light unit; P <0.05), and cysteine oxidation of HDAC4 was decreased. HDAC4 oxidation and cardiac hypertrophy were also attenuated in cardiac-specific Nox4 knockout mice 2 weeks after transverse aortic constriction. Conclusions: Nox4 plays an essential role in mediating cysteine oxidation and nuclear exit of HDAC4, thereby mediating cardiac hypertrophy in response to phenylephrine and pressure overload.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/circresaha.112.279760

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
Oxidative stress and heart failure
Tsutsui, H., Kinugawa, S., & Matsushima, S. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00554.2011 · Cited by 1,277
Self-citation
A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation
Erickson, J. R., Joiner, M.-L. A., Guan, X., Kutschke, W., Yang, J., Oddis, C. V., Bartlett, R. K., Lowe, J. S., O'Donnell, S. E., Aykin-Burns, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.048 · Cited by 1,122
Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases
Martyn, K. D., Frederick, L. M., von Loehneysen, K., Dinauer, M. C., & Knaus, U. G. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.03.023 · Cited by 783
NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart
Kuroda, J., Ago, T., Matsushima, S., Zhai, P., Schneider, M. D., & Sadoshima, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002178107 · Cited by 772
Self-citation
Structure, regulation and evolution of Nox‐family NADPH oxidases that produce reactive oxygen species
Sumimoto, H. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06488.x · Cited by 740
CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy
Backs, J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27438 · Cited by 514
Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes
Ago, T., Kuroda, J., Pain, J., Fu, C., Li, H., & Sadoshima, J. (2010) · Circulation Research · doi:10.1161/circresaha.109.213116 · Cited by 506
Self-citation
NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis
Zhang, M., Brewer, A. C., Schröder, K., Santos, C. X. C., Grieve, D., Wang, M., Anilkumar, N. P., Yu, B., Dong, X., Walker, S. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009700107 · Cited by 452
Control of Cardiac Growth by Histone Acetylation/Deacetylation
Backs, J., & Olson, E. N. (2006) · Circulation Research · doi:10.1161/01.res.0000197782.21444.8f · Cited by 440

Flagged first, then by citations

Show all 25 references

1 of the 25 references couldn’t be matched to a known paper.

Sorted by citations

Items 101–189 of 189

AQP1 differentially orchestrates endothelial cell senescence
Shabanian, K., Shabanian, T., Karsai, G., Pontiggia, L., Paneni, F., Ruschitzka, F. T., Beer, J. H., & Saravi, S. S. S. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103317 · Cited by 25
Functional Role of Nox4 in Autophagy
Forte, M., Palmerio, S., Yee, D., Frati, G., & Sciarretta, S. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_16 · Cited by 25
Natural Bioactive Compounds Targeting NADPH Oxidase Pathway in Cardiovascular Diseases
Sofiullah, S. S. M., Murugan, D. D., Muid, S. A., Wu, Y. S., Kadir, S. Z. S. A., Abas, R., Ridzuan, N. R. A., Zamakshshari, N. H., & Choy, K. W. (2023) · Molecules · doi:10.3390/molecules28031047 · Cited by 28
NADPH oxidases—do they play a role in TRPC regulation under hypoxia?
Malczyk, M., Veith, C., SCHERMULY, R. T., Gudermann, T. W., Dietrich, A., Sommer, N., Weißmann, N., & Pak, O. (2015) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-015-1731-3 · Cited by 24
The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes
Mizushima, W., Takahashi, H., Watanabe, M., Kinugawa, S., Matsushima, S., Takada, S., Yokota, T., Furihata, T., Matsumoto, J., Tsuda, M., et al. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.09.013 · Cited by 24
Self-citation
Role of intracellular angiotensin II
Ré, R. N. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00632.2017 · Cited by 24
Paracrine Mechanisms of Redox Signalling for Postmitotic Cell and Tissue Regeneration
Hervera, A., Santos, C. X. C., Virgiliis, F. D., Shah, A. M., & Giovanni, S. D. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.01.006 · Cited by 24
Lanthanum decreased VAPB-PTPP51, BAP31-FIS1, and MFN2-MFN1 expression of mitochondria-associated membranes and induced abnormal autophagy in rat hippocampus
Liu, J., Wang, L., Ge, L., Sun, W., Song, Z., Lu, X., Jin, C., Wu, S., & Yang, J. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.112831 · Cited by 25
NOX4 inhibition promotes the remodeling of dystrophic muscle
Hammers, D. W. (2022) · JCI Insight · doi:10.1172/jci.insight.158316 · Cited by 22
NOX4 Mediates Epithelial Cell Death in Hyperoxic Acute Lung Injury Through Mitochondrial Reactive Oxygen Species
Harijith, A. K., Basa, P., Ha, A. W., Thomas, J., Jafri, A., Fu, P., MacFarlane, P. M., Raffay, T. M., Natarajan, V., & Sudhadevi, T. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.880878 · Cited by 23
G6PD, bond by miR-24, regulates mitochondrial dysfunction and oxidative stress in phenylephrine-induced hypertrophic cardiomyocytes
Li, B., Wang, X., Yu, M., Yang, P. C., & Wang, W. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118378 · Cited by 20
NOX4 Mediates Pseudomonas aeruginosa-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium
Fu, P., Ramchandran, R., Sudhadevi, T., Kumar, P. P., Krishnan, Y., Liu, Y., Zhao, Y., Parinandi, N. L., Harijith, A. K., Sadoshima, J., et al. (2021) · Antioxidants · doi:10.3390/antiox10030477 · Cited by 19
Self-citation
Involvement of vascular peroxidase 1 in angiotensin II–induced hypertrophy of H9c2 cells
Yang, W., Liu, Z., Xu, Q., Peng, H., Chen, L., Huang, X. Y., Yang, T., Yu, Z., Cheng, G., Zhang, G., et al. (2016) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2016.08.002 · Cited by 19
Targeting NRF2 to suppress ferroptosis in brain injury.
Song, S., Gao, Y., Sheng, Y., Rui, T., & Luo, C. (2021) · PubMed · doi:10.14670/hh-18-286 · Cited by 20
Cardiac Cell Senescence and Redox Signaling
Cesselli, D., Aleksova, A., Sponga, S., Cervellin, C., Loreto, C. D., Tell, G., & Beltrami, A. P. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00038 · Cited by 20
Advances in the study of nicotinamide adenine dinucleotide phosphate oxidase in myocardial remodeling
Miao, R., Wang, L., Chen, Z., Ge, S., Li, L., Zhang, K., Chen, Y., Guo, W., Duan, X., Zhu, M., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.1000578 · Cited by 18
RasGRF Couples Nox4-Dependent Endoplasmic Reticulum Signaling to Ras
Wu, R. F., Liao, C., hatoum, H. H., Fu, G., Ochoa, C. D., & Terada, L. S. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307922 · Cited by 19
EndophilinA2 protects against angiotensin II‐induced cardiac hypertrophy by inhibiting angiotensin II type 1 receptor trafficking in neonatal rat cardiomyocytes
Liu, Y., Shen, H., Wang, X.-Q.-Y., Liu, H.-Q., Zheng, L., & Luo, J. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26862 · Cited by 20
NOX-dependent reactive oxygen species production underlies arrhythmias susceptibility in dexamethasone-treated rats
Macedo, F. N., Souza, D. S., Araújo, J. E. D. S., Dantas, C. O., Miguel‐dos‐Santos, R., Silva‐Filha, E., Rabelo, T. K., dos Santos, R. V., Zhang, R., Barreto, A. S., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.03.005 · Cited by 18
Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison
Meneses‐Valdés, R., Gallero, S., Henríquez‐Olguín, C., & Jensen, T. E. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.07.035 · Cited by 17
Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML
Moloney, J. N., Jayavelu, A. K., Stanicka, J., Roche, S. L., O’Brien, R. L., Scholl, S., Böhmer, F.-D., & Cotter, T. G. (2017) · Oncotarget · doi:10.18632/oncotarget.22241 · Cited by 19
Calorie restriction attenuates hypertrophy-induced redox imbalance and mitochondrial ATP-sensitive K+ channel repression
David, C. E. B., Lucas, A. M. B., Araújo, M. T. S., Coelho, B. N., Neto, J. B. S., Portela, B. R. C., Varela, A. L. N., Kowaltowski, A. J., & Facundo, H. T. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.08.008 · Cited by 17
Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1
Chen, L., Zhao, M., Li, J., Wang, Y., Bao, Q., Wu, S., Deng, X., Tang, X., Wu, W., & Liu, X. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1260210 · Cited by 17
The Dual Role of NOX4 in Cardiovascular Diseases: Driver of Oxidative Stress and Mediator of Adaptive Remodeling
Labbé, P., Thorin, É., & Thorin‐Trescases, N. (2025) · Antioxidants · doi:10.3390/antiox14091137 · Cited by 16
Effect of exercise and curcumin on cardiomyocyte molecular mediators associated with oxidative stress and autophagy in aged male rats
Aziz, S. G., Pourheydar, B., Chodari, L., & Hamidifar, F. (2022) · Microvascular Research · doi:10.1016/j.mvr.2022.104380 · Cited by 16
Nuclear Cytoplasmic Trafficking of Proteins is a Major Response of Human Fibroblasts to Oxidative Stress
Baqader, N. O., Radulović, M., Crawford, M., Stoeber, K., & Godovac‐Zimmermann, J. (2014) · Journal of Proteome Research · doi:10.1021/pr500638h · Cited by 16
Genetically Encoded Biosensors to Monitor Intracellular Reactive Oxygen and Nitrogen Species and Glutathione Redox Potential in Skeletal Muscle Cells
Fernández-Puente, E., & Palomero, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910876 · Cited by 16
Elevated meteorin-like protein from high-intensity interval training improves heart function via AMPK/HDAC4 pathway
Wang, Y., Yuan, J., Liu, H., Chen, J., Zou, J., Zeng, X., Du, L., Sun, X., Xia, Z., Geng, Q., et al. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.101100 · Cited by 15
Luminal flow induces NADPH oxidase 4 translocation to the nuclei of thick ascending limbs
Sáez, F., Hong, N. J., & Garvin, J. L. (2016) · Physiological Reports · doi:10.14814/phy2.12724 · Cited by 15
Post-translational modifications talk and crosstalk to class IIa histone deacetylases
Guttzeit, S., & Backs, J. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.08.007 · Cited by 14
DDIT4 gene expression is switched on by a new HDAC4 function in ataxia telangiectasia
Ricci, A., Galluzzi, L., Magnani, M., & Menotta, M. (2019) · The FASEB Journal · doi:10.1096/fj.201902039r · Cited by 15
Chemical biology approaches to uncovering nuclear ROS control
Zhang, J., & Bar‐Peled, L. (2023) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2023.102352 · Cited by 12
Interleukin enhancement binding factor 3 inhibits cardiac hypertrophy by targeting asymmetric dimethylarginine-nitric oxide
Yang, R., Tan, X. L., Ge, L.-J., Sun, J., Peng, X.-D., & Wang, W. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.09.002 · Cited by 11
Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy
Zhang, R., Xu, X., Chen, X., Hao, C., Ji, Z., Zuo, P., Yang, M., Ma, G., & Li, Y. (2022) · BMC Genomics · doi:10.1186/s12864-022-08778-0 · Cited by 11
Inhibition of the ROS-EGFR Pathway Mediates the Protective Action of Nox1/4 Inhibitor GKT137831 against Hypertensive Cardiac Hypertrophy via Suppressing Cardiac Inflammation and Activation of Akt and ERK1/2
Zeng, S., Yan, Q., Yang, L., Mei, Q., & Lu, H. (2020) · Mediators of Inflammation · doi:10.1155/2020/1078365 · Cited by 11
Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas
Ferreira, W. A. S., Vitiello, G. A. F., Medina, T. D. S., & de Oliveira, E. H. C. (2022) · Scientific Reports · doi:10.1038/s41598-022-10114-1 · Cited by 12
Unraveling the toxic link between pesticides and brain cancer: a review on molecular mechanisms, signaling pathways and future research trends
Ahmad, M. B., Islam, A. U., Hassan, S., Tarfeen, N., Nisa, K. U., Nisar, K., Hassan, T., Ganiee, S. A., Bhat, A. R., & Ganai, B. A. (2025) · The Nucleus · doi:10.1007/s13237-024-00529-8 · Cited by 10
Demystifying the management of cancer through smart nano-biomedicine via regulation of reactive oxygen species
Mishra, A. P., Kumar, R., Harilal, S., Nigam, M., Datta, D., Singh, S. K., Waranuch, N., & Chittasupho, C. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03469-x · Cited by 9
HDAC4 Inhibitors as Antivascular Senescence Therapeutics
Huang, C., Lin, Z., Liu, X., Ding, Q., Cai, J., Zhang, Z., Rose, P., & Zhu, Y. Z. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3087916 · Cited by 9
Regulation of cardiovascular diseases by histone deacetylases and NADPH oxidases
Yan, H. M., Yin, Y., Zhou, Y., Li, Z., Li, Y., Ren, L., Wen, J., & Wang, W. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103379 · Cited by 8
Cardiac CIP protein regulates dystrophic cardiomyopathy
He, X., Liu, J., Gu, F., Chen, J., Lu, Y. W., Ding, J., Guo, H., Nie, M., Kataoka, M., Lin, Z., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.08.022 · Cited by 8
Oxidative stress and its related epigenetic modifications in vascular calcification: mechanisms and advances
Lin, Y., Zhang, H., Jiang, Y., & Tian, W. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1662989 · Cited by 5
Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling
Byrne, N. J., Koentges, C., Khan, E., Pfeil, K., Sandulescu, R., Bakshi, S., Költgen, C., Vosko, I., Gollmer, J., Rathner, T., et al. (2025) · Journal of Molecular and Cellular Cardiology Plus · doi:10.1016/j.jmccpl.2025.100299 · Cited by 5
Galectin-3 reflects the echocardiographic quantification of right ventricular failure
Ansari, U., Behnes, M., Hoffmann, J., Weidner, K., Kuche, P., Rusnak, J., Kim, S., Natale, M., Reckord, N., Lang, S., et al. (2021) · Scandinavian Cardiovascular Journal · doi:10.1080/14017431.2021.1995036 · Cited by 5
Delineating the NOX-Mediated Promising Therapeutic Strategies for the Management of Various Cardiovascular Disorders: A Comprehensive Review
Upadhyay, R. K., Kumar, K., Vishwakarma, V. K., Singh, N., Narang, R., Parakh, N., Yadav, M., Yadav, S., Kumar, S., Goyal, A., et al. (2024) · Current Vascular Pharmacology · doi:10.2174/0115701611308870240910115023 · Cited by 6
Dioxygen and Metabolism; Dangerous Liaisons in Cardiac Function and Disease
Angelini, A., Pi, X., & Xie, L. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01044 · Cited by 6
Self-citation
An emerging role for cysteine-mediated redox signaling in aging
Jin, M. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103852 · Cited by 6
Organoselenocyanate-Conjugated NBDHEX Derivatives as Potent Anticancer Agents for the Treatment of Breast Cancer via ROS-Regulated Signaling Pathways
Pal, N., Kesarwani, R., Mandal, T. K., & Bhabak, K. P. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c02154 · Cited by 3
Calorie restriction anti-hypertrophic effects are associated with improved mitochondrial content, blockage of Ca 2+ -induced mitochondrial damage, and lower reverse electron transport-mediated oxidative stress
Lucas, A. M. B., Palácio, P. B., Cunha, P. L. O., & Facundo, H. T. (2024) · Free Radical Research · doi:10.1080/10715762.2024.2342962 · Cited by 3
Histone deacetylase 4: A therapeutic target for cardiovascular diseases (Review)
Ma, X., Wei, R., Song, A., Zhang, X., Zou, J., & Hao, S. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5599 · Cited by 2
NOX2-induced oxidative stress triggers cardiac hypercontractility during severe malaria
de Oliveira, K., Silva, A. O., Bruno, A. S., Ito, H. N., Queiroz‐Junior, C. M., Berg, B. B., Castor, M. G. M. E., Machado, F. S., Ceron, C. S., Teixeira, M. M., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123928 · Cited by 2
NOX4 promotes cardiomyocyte ferroptosis-related injury in septic cardiomyopathy in associated with mitochondrial dysfunction and impaired NRF2 nuclear translocation
Qin, S., Chen, C. F., Wang, X., Deng, L., Wang, J., Zhu, C., Zhu, C., Cao, Y., & Zhang, S. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.153230 · Cited by 2
Knockdown of ANGPTL2 promotes left ventricular systolic dysfunction by upregulation of NOX4 in mice
Labbé, P., Martel, C., Shi, Y., Montezano, A. C. I., He, Y., Gillis, M., Higgins, M., Villeneuve, L. R., Touyz, R. M., Tardif, J., et al. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1320065 · Cited by 2
Pathogenesis of Macrovascular Complications in Diabetes
Gray, S. P., Marco, E. D., Candido, R., Cooper, M. E., & Jandeleit-Dahm, K. A. M. (2016) · Wiley eBooks · doi:10.1002/9781118924853.ch41 · Cited by 2
Effects of calorie restriction on reactive oxygen species production by mitochondrial reverse electron transport, mitochondrial permeability transition pore, and beta-adrenergic stimulation during cardiac hypertrophyPreprint
Lucas, A. M. B., Palácio, P. B., Cunha, P. L. O., & Facundo, H. T. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.02.478846 · Cited by 2
Oxidative Stress and Antioxidant Strategies in Human Diseases
Yuan, K., & Zhang, Y. (2021) · Springer eBooks · doi:10.1007/978-981-16-0522-2_1 · Cited by 2
Goreisan attenuates cardiac hypertrophy and diastolic dysfunction in heart failure with preserved ejection fraction induced by HFD/L-NAME via regulation of ICAT-β-catenin/ERK axis
Isayama, Y. S., Matsushima, S., Shinohara, K., Isayama, K., Enzan, N., Yamamoto, T., Sada, M., Miyake, R., Tsutsui, Y., Toyohara, T., et al. (2025) · Hypertension Research · doi:10.1038/s41440-025-02348-z · Cited by 1
Self-citation
The multifactorial role of HDAC9 at the maternal–fetal interface in the pathogenesis of preeclampsia
Opichka, M. A., McIntosh, J. J., & Grobe, J. L. (2025) · Clinical Science · doi:10.1042/cs20242385 · Cited by 1
BRD4 Inhibition alleviates sepsis-associated acute kidney injury via suppression of NOX4-mediated oxidative stress and inflammation
Jia, J., Ji, K., Zhou, Y., Huang, Y., Li, A., Fan, Y., Huang, W., Chen, F., & Lu, G. (2026) · Cell Death Discovery · doi:10.1038/s41420-026-03113-y · Cited by 1
Making sense of subcellular H2O2 in mammals
Waldeck‐Weiermair, M., Covington, T. A., Pandey, A. K., & Michel, T. M. (2026) · Redox Biochemistry and Chemistry · doi:10.1016/j.rbc.2026.100080 · Cited by 1
Nicotinamide adenine dinucleotide phosphate oxidase 4 in lung disease: a review of its biology and therapeutic potential
Wang, Y., Ben, T., Fang, J., Li, Z., Ding, J., Xu, L., Lin, K., & Jiang, L. (2026) · Experimental Biology and Medicine · doi:10.3389/ebm.2026.10941 · Cited by 2
From Defense to Disease: NADPH Oxidase in Cellular Function and Dysregulation
Prasad, A., Kushwaha, R., Alugoju, P., Pospíšil, P., & Rathi, D. (2026) · Journal of Immunology Research · doi:10.1155/jimr/2847417 · Cited by 1
Nox4: From Discovery to Pathophysiology
Hecker, L., Kato, K., & Griendling, K. K. (2023) · Springer eBooks · doi:10.1007/978-3-031-23752-2_12 · Cited by 2
Cell Cycle, DNA Damage Repair Systems, and Impact of Redox Regulation in Cancer
Bansal, M. P. (2023) · Springer eBooks · doi:10.1007/978-981-99-7342-2_8 · Cited by 1
Cardiomyocytes in Heart Failure
Kartha, C. C. (2021) · Springer eBooks · doi:10.1007/978-3-030-85536-9_15 · Cited by 1
Cardioprotective natural compound pinocembrin prevents acute ischemic myocardial injury through enhancing glycolysisPreprint
Lin, J., Zheng, Y., Wan, G., & Gu, X. (2020) · doi:10.22541/au.159007727.72815269 · Cited by 1
Pathogenesis of Macrovascular Complications in Diabetes
Østergaard, J. A., Block, T. J., Dahm, S. I., Khan, W., & Jandeleit-Dahm, K. A. M. (2024) · Wiley eBooks · doi:10.1002/9781119697473.ch46 · Cited by 1
Hydrogen Peroxide induces resistance to DNA damage in a localization and p53 dependent mannerPreprint
Keijer, J. P., Polderman, P. E., Alcaraz, P. S., van Es, R. M., González, D. M., Kok, R. N. U., Baghdadi, S. E., Gulersonmez, C. M. C., Stigter, E. C. A., Vos, H. R., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.13.724825 · Cited by 1
Recent Advances in Cardiac Myocyte Biology and Function
Hong, K. U., & Moore, J. B. (2013) · Circulation Research · doi:10.1161/circresaha.113.302990
Rational Design and Therapeutic Potential of a Novel Nox1 Inhibitor for the Treatment of Pulmonary Hypertension: In Vitro and In Vivo Effects of Nox1 Inhibition
Ranayhossaini, D. (2014) · D-Scholarship@Pitt (University of Pittsburgh)
REGULATION OF CARDIAC AUTOPHAGY IN RESPONSE TO LIPID OVERLOAD
Jaishy, B. P. (2013)
HDAC Signaling Networks in Heart Failure
Kronlage, M., Katus, H. A., & Backs, J. (2016) · Cardiac and vascular biology · doi:10.1007/978-3-319-41457-7_8
Application of redox biosensor mouse models to study redox processes in cardiomyocytes
Nanadikar, M. S. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7597
Soft electrophile inhibition of selenoenzymes in disease pathologies
Ralston, N. V. C., & Raymond, L. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819092-0.00040-6
心筋リモデリングにおけるFynによるNox4制御機構
松島, 将., Sadoshima, J., & 裕之, 筒. (2017) · Journal of JCS Cardiologists · doi:10.1253/jjcsc.25.2_157
Self-citation
Genetically Encoded Biosensors to Monitor Intracellular Reactive Oxygen and Nitrogen Species and Glutathione Redox Potential in Skeletal Muscle Cells
Fernández-Puente, E., & Palomero, J. (2022) · Vide Leaf, Hyderabad eBooks · doi:10.37247/pamol3ed.3.2022.16
Additional file 1 of Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy
Zhang, R., Xu, X., Chen, X., Hao, C., Ji, Z., Zuo, P., Yang, M., Ma, G., & Li, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20486800
Additional file 4 of Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy
Zhang, R., Xu, X., Chen, X., Hao, C., Ji, Z., Zuo, P., Yang, M., Ma, G., & Li, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20486809
Additional file 3 of Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy
Zhang, R., Xu, X., Chen, X. X., Hao, C., Ji, Z., Zuo, P., Yang, M., Ma, G., & Li, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20486806
Additional file 2 of Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy
Zhang, R., Xu, X., Chen, X., Hao, C., Ji, Z., Zuo, P., Yang, M., Ma, G., & Li, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20486803
Aqp1 Differentially Orchestrates Endothelial Cell SenescencePreprint
Shabanian, K., Shabanian, T., Karsai, G., Lettlová, S., Pontiggia, L., Ruschitzka, F. T., Beer, J. H., & Saravi, S. S. S. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4818945
Exploration of small molecule compounds targeting abdominal aortic aneurysm based on CMap database and molecular dynamics simulation
Li, F., Zhuo, L., Xie, F., Luo, H., Li, Y., Lin, H., & Li, X. (2024) · Vascular · doi:10.1177/17085381241273289
Additional file 5 of Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophy
Zhang, R., Xu, X., Chen, X., Hao, C., Ji, Z., Zuo, P., Yang, M., Ma, G., & Li, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20486812
Preservative-free latanoprost induces meibomian gland dysfunction through inflammatory and oxidative stress pathways
Huang, C., Yang, Y., Wu, S., Liu, Z., Chen, L., Yan, D., Wei, M., Yan, K., Wang, R., Hu, J., et al. (2026) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-025-01078-9
Comparative analysis of laboratory and instrumental markers of cardiovascular remodeling in patients with arterial hypertension and coronary heart disease in the Far North and temperate climate zones
Musikhina, N. A., Евгеньевич, Ш. Н., Викторовна, Д. Н., Gorbatenko, E. A., Larionova, O. N., Tuzmukhametova, O. H., & Анатольевич, А. Д. (2026) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2025-2576
Characterization of an auranofin-resistant ovarian cancer cell line A2780
Limaj, X. (2024) · theses.fr (ABES) · doi:10.70675/5f21b24bzd436z4168z8555zdc660e2b2aca
Natural product clitorin reduces myocardial damage following acute myocardial infarction by mediating NOX4/Nrf2 redox balance
Pan, X., Yang, Y., Liu, C., Xu, L., Yu, J., Ge, S., Wang, W., Wang, C., Wei, W., Wu, S., et al. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179127
BindingDB Entry 50002202: Design, synthesis, and biological evaluation of inhibitors of the NADPH oxidase, Nox4.
BindingDB (2020) · UC San Diego · doi:10.7270/q2vd722w
BindingDB Entry 50043797: Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.
BindingDB (2014) · UC San Diego · doi:10.7270/q2dz09rk

Authors: Matsushima, S., Kuroda, J., Ago, T., Zhai, P., Park, J. Y., Xie, L.-H., Tian, B., & Sadoshima, J.
Affiliations: University of Medicine and Dentistry of New Jersey (US)
ORCID: Matsushima, Shouji
Kuroda, Junya
Ago, Tetsuro
Zhai, Peiyong
Xie, Lai-Hua
Tian, Bin
Sadoshima, Junichi
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-02-15
Volume: 112
Issue: 4
Pages: 651-663
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.112.279760
PMC: PMC3574183
OpenAlex: W2140538799
Cited by: 183
References: 25
Citations by year: 2026: 9 · 2025: 11 · 2024: 11 · 2023: 11 · 2022: 16 · 2021: 9 · 2020: 12 · 2019: 11 · 2018: 11 · 2017: 22 · 2016: 20 · 2015: 16 · 2014: 14 · 2013: 10
FWCI: 8.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Japan Society for the Promotion of Science (21390243)
National Institute on Aging (AG23039, R01AG023039, R21AG042678)
National Heart, Lung, and Blood Institute (R21HL098802, HL91469, R01HL067724, HL102738, R01HL102738, R01HL112330, HL-67724, R01HL091469, HL112330)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: NOX4, HDAC4, cysteine oxidation, cardiac hypertrophy, superoxide, class II histone deacetylases, phenylephrine, pressure overload, transverse aortic constriction, cardiomyocytes, oxidative stress
MeSH terms: NADPH Oxidase 2, NADPH Oxidase 4, Animals, Aortic Valve Stenosis, Cell Nucleus, Cysteine, Enzyme Activation, Enzyme Induction, Cardiomegaly, Histone Deacetylases, Male, Membrane Glycoproteins, Mice, Transgenic, Nuclear Envelope, Oxidation-Reduction, Phenylephrine, Recombinant Fusion Proteins, Reactive Oxygen Species, Mice, Knockout, Oxidative Stress, NADPH Oxidases, Protein Transport, Myocytes, Cardiac, Cell Size, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks