The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Smooth Muscle Cell Plasticity: Fact or Fiction?
Open accessAbstract
More than 50 years ago, smooth muscle cells (SMC) of the carotid artery were shown to undergo "de-differentiation" upon ligation injury. 1 Since this classic study, scores of research groups have used a variety of in vivo and in vitro model systems as well as numerous clinical studies to demonstrate the conversion of normally contractile vascular SMC to a less differentiated state of proliferation, migration, and exuberant extracellular matrix secretion, a process generally referred to as phenotypic modulation or plasticity [reviewed in 2-6]. Such changes in vascular SMC phenotype are thought to underlie many vascular occlusive diseases. However, in a recent issue of Nature Communications , Tang et al 7 provide data from in vitro cell culture, flow cytometry, and lineage tracing experiments which they believe directly challenge this long-standing and widely accepted paradigm. Specifically, these authors contend that: (1) differentiated (SM myosin heavy chain, SM MHC+) vascular SMC are incapable of proliferation either in vivo in response to injury or in vitro in cell culture; (2) within the media of mature blood vessels there exists a small population (
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A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991
The Tunica Adventitia of Human Arteries and Veins As a Source of Mesenchymal Stem Cells
Corselli, M., Chen, C.-W., Sun, B., Yap, S., Rubin, J. P., & Péault, B. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0200 · Cited by 393
Cited by
Mechanisms of plaque formation and rupture
Bentzon, J. F., Otsuka, F., Virmani, R., & Falk, E. (2014) · Circulation Research · doi:10.1161/circresaha.114.302721 · Cited by 2,391
Vascular smooth muscle cells in atherosclerosis
Bennett, M. R., Sinha, S., & Owens, G. K. (2016) · Circulation Research · doi:10.1161/circresaha.115.306361 · Cited by 2,179
Self-citationShankman, L. S., Gomez, D., Cherepanova, O. A., Salmon, M., Alencar, G. F., Haskins, R. M., Swiatlowska, P., Newman, A. A. C., Greene, E. S., Straub, A. C., et al. (2015) · Nature Medicine · doi:10.1038/nm.3866 · Cited by 1,218
Self-citationCell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis
Mussbacher, M., Salzmann, M., Brostjan, C., Hoesel, B., Schoergenhofer, C., Datler, H., Hohensinner, P., Basílio, J., Petzelbauer, P., Assinger, A., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00085 · Cited by 596
Transdifferentiation of Vascular Smooth Muscle Cells to Macrophage-Like Cells During Atherogenesis
Feil, S., Fehrenbacher, B., Lukowski, R., Essmann, F., Schulze-Osthoff, K., Schaller, M., & Feil, R. (2014) · Circulation Research · doi:10.1161/circresaha.115.304634 · Cited by 578
Metadata
- Authors
- Nguyen, A. T., Gomez, D., Bell, R. D., Campbell, J. H., Clowes, A. W., Gabbiani, G., Giachelli, C. M., Parmacek, M. S., Raines, E. W., Rusch, N. J., Speer, M. Y., Sturek, M., Thyberg, J., Towler, D. A., Weiser-Evans, M. C., Yan, C., Miano, J. M., & Owens, G. K.
- Venue
- Circulation Research
- Published
- 2013-01-04
- Volume
- 112
- Issue
- 1
- Pages
- 17-22
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2129555959
- Cited by
- 162
- References
- 2
- FWCI
- 9.78
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Nguyen, A. T., Gomez, D., Bell, R. D., Campbell, J. H., Clowes, A. W., Gabbiani, G., Giachelli, C. M., Parmacek, M. S., Raines, E. W., Rusch, N. J., Speer, M. Y., Sturek, M., Thyberg, J., Towler, D. A., Weiser-Evans, M. C., Yan, C., Miano, J. M., & Owens, G. K. (2013). Smooth Muscle Cell Plasticity: Fact or Fiction? Circulation Research. https://doi.org/10.1161/circresaha.112.281048
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
