The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Vitamin D and Cardiovascular Disease
Open accessAbstract
Vitamin D plays a classical hormonal role in skeletal health by regulating calcium and phosphorus metabolism. Vitamin D metabolites also have physiological functions in nonskeletal tissues, where local synthesis influences regulatory pathways via paracrine and autocrine mechanisms. The active metabolite of vitamin D, 1α,25-dihydroxyvitamin D, binds to the vitamin D receptor that regulates numerous genes involved in fundamental processes of potential relevance to cardiovascular disease, including cell proliferation and differentiation, apoptosis, oxidative stress, membrane transport, matrix homeostasis, and cell adhesion. Vitamin D receptors have been found in all the major cardiovascular cell types including cardiomyocytes, arterial wall cells, and immune cells. Experimental studies have established a role for vitamin D metabolites in pathways that are integral to cardiovascular function and disease, including inflammation, thrombosis, and the renin–angiotensin system. Clinical studies have generally demonstrated an independent association between vitamin D deficiency and various manifestations of degenerative cardiovascular disease including vascular calcification. However, the role of vitamin D supplementation in the management of cardiovascular disease remains to be established. This review summarizes the clinical studies showing associations between vitamin D status and cardiovascular disease and the experimental studies that explore the mechanistic basis for these associations.
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Cites
Holick, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra070553 · Cited by 13,720
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
Li, Y. C., Kong, J., Wei, M., Chen, Z.-F., Liu, S. Q., & Cao, L.-P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215219 · Cited by 1,625
Global vitamin D status and determinants of hypovitaminosis D
on behalf of the IOF Committee of Scientific Advisors (CSA) Nutrition Working Group, Mithal, A., Wahl, D. A., Bonjour, J.-P., Burckhardt, P., Dawson-Hughes, B., Eisman, J. A., El-Hajj Fuleihan, G., Josse, R. G., Lips, P., et al. (2009) · Osteoporosis International · doi:10.1007/s00198-009-0954-6 · Cited by 1,472
Calcitriol blunts the deleterious impact of advanced glycation end products on endothelial cells
Talmor, Y., Golan, E., Benchetrit, S., Bernheim, J., Klein, O., Green, J., & Rashid, G. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00051.2008 · Cited by 169
Hyppönen, E., Berry, D., Cortina-Borja, M., & Power, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010801 · Cited by 96
Vaidya, A., Forman, J. P., Hopkins, P. N., Seely, E. W., & Williams, J. S. (2011) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320310391922 · Cited by 93
Cited by
Vascular calcification: Mechanisms of vascular smooth muscle cell calcification
Leopold, J. A. (2015) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2014.10.021 · Cited by 468
The Role of Vitamin D in the Aging Adult
Meehan, M., & Penckofer, S. (2014) · Journal of Aging and Gerontology · doi:10.12974/2309-6128.2014.02.02.1 · Cited by 189
Vitamin D and chronic diseases: the current state of the art
Muscogiuri, G., Altieri, B., Annweiler, C., Balercia, G., Pal, H. B., Boucher, B. J., Cannell, J. J., Foresta, C., Grübler, M. R., Kotsa, K., et al. (2017) · Archives of Toxicology · doi:10.1007/s00204-016-1804-x · Cited by 151
Effects of Vitamin D Supplementation on Muscle Strength in Athletes: A Systematic Review
Chiang, C.-M., Ismaeel, A., Griffis, R. B., & Weems, S. (2017) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001518 · Cited by 130
Teixeira, T. M., da Costa, D. C., Resende, A. C., Soulage, C. O., Bezerra, F. F., & Daleprane, J. B. (2017) · The Journal of Nutrition · doi:10.3945/jn.116.239475 · Cited by 106
Metadata
- Authors
- Norman, P. E., & Powell, J. T.
- Venue
- Circulation Research
- Published
- 2014-01-17
- Volume
- 114
- Issue
- 2
- Pages
- 379-393
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2128749750
- Cited by
- 576
- References
- 6
- FWCI
- 41.22
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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