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Cited by 96Vitamin D Research StudiesAntioxidant Activity and Oxidative StressNutritional Studies and Diet

25-Hydroxyvitamin D and pre-clinical alterations in inflammatory and hemostatic markers: a cross sectional analysis in the 1958 British Birth Cohort

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Hyppönen, Elina, Berry, Diane, Cortina-Borja, Mario, Power, Chris·2010·PLoS ONE
DOI 10.1371/journal.pone.0010801PMC PMC2875406
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Abstract

BACKGROUND: Vitamin D deficiency has been suggested as a cardiovascular risk factor, but little is known about underlying mechanisms or associations with inflammatory or hemostatic markers. Our aim was to investigate the association between 25-hydroxyvitamin D [25(OH)D, a measure for vitamin D status] concentrations with pre-clinical variations in markers of inflammation and hemostasis. METHODOLOGY/PRINCIPAL FINDINGS: Serum concentrations of 25(OH)D, C-reactive protein (CRP), fibrinogen, D-dimer, tissue plasminogen activator (tPA) antigen, and von Willebrand factor (vWF) were measured in a large population based study of British whites (aged 45 y). Participants for the current investigation were restricted to individuals free of drug treated cardiovascular disease (n = 6538). Adjusted for sex and month, 25(OH)D was inversely associated with all outcomes (p < or =0.015 for all), but associations with CRP, fibrinogen, and vWF were explained by adiposity. Association with tPA persisted after full adjustment (body mass index, waist circumference, physical activity, TV watching, smoking, alcohol consumption, social class, sex, and month), and average concentrations were 18.44% (95% CI 8.13, 28.75) lower for 25(OH)D > or =75 nmol/l compared to < 25 nmol/l. D-dimer concentrations were lower for participants with 25(OH)D 50-90 nmol/l compared to others (quadratic term p = 0.01). We also examined seasonal variation in hemostatic and inflammatory markers, and evaluated 25(OH)D contribution to the observed patterns using mediation models. TPA concentrations varied by season (p = 0.02), and much of this pattern was related to fluctuations in 25(OH)D concentrations (p < or =0.001). Some evidence of a seasonal variation was observed also for fibrinogen, D-dimer and vWF (p < 0.05 for all), with 25(OH)D mediating some of the pattern for fibrinogen and D-dimer, but not vWF. CONCLUSIONS: Current vitamin D status was associated with tPA concentrations, and to a lesser degree with fibrinogen and D-dimer, suggesting that vitamin D status/intake may be important for maintaining antithrombotic homeostasis.

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  • A higher number of vegetable and fruit varieties consumed was inversely correlated with blood CRP levels.

    “A high number of varieties of vegetables and fruits were inversely correlated with blood CRP levels (322) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [322]

  • Of ten cross-sectional studies, seven reported an inverse association between high vegetable and fruit intake, alone or combined, and blood CRP concentrations.

    “Of the ten cross-sectional studies, seven reported an inverse association between a high intake of vegetables and fruits, either in combination or alone, and blood CRP concentrations (322 -325,327 -329) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [322]

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Authors
Hyppönen, E., Berry, D., Cortina-Borja, M., & Power, C.
Affiliations
University College London (GB)
Corresponding author
Hyppönen, Elina
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2010-05-24
Volume
5
Issue
5
Pages
e10801
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0010801
PMC
PMC2875406
OpenAlex
W2070237142
Cited by
96
References
55
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 8 · 2015: 11 · 2014: 14 · 2013: 17 · 2012: 12
FWCI
7.80
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UniSA Research Outputs Repository (University of South Australia) (acceptedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • National Institute for Health and Care Research (PHCS/C4/4/016)
  • British Heart Foundation (PG/09/023, G0000934)
  • Bupa Foundation
  • University College London
  • Great Ormond Street Hospital for Children
  • Medical Research Council (G0601653, G0000934)
  • Institute of Education, University of London
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
25-hydroxyvitamin D, vitamin D status, vitamin D deficiency, cardiovascular risk, inflammation, hemostasis, C-reactive protein, fibrinogen, D-dimer, tissue plasminogen activator, von Willebrand factor, adiposity, seasonal variation, mediation, 1958 British birth cohort, middle-aged adults, cardiovascular disease
MeSH terms
C-Reactive Protein, Cross-Sectional Studies, Female, Fibrinogen, United Kingdom, Hemostasis, Humans, Inflammation, Male, Middle Aged, Tissue Plasminogen Activator, Seasons, Vitamin D, von Willebrand Factor, Cohort Studies, Biomarkers, Body Mass Index, Parturition, Waist Circumference

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