25-Hydroxyvitamin D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians

Vaidya, Anand; Forman, John P; Hopkins, Paul N; Seely, Ellen W; Williams, Jonathan S

doi:10.1177/1470320310391922

Cited by 93Renin-Angiotensin System StudiesSodium Intake and HealthVitamin D Research Studies

25-Hydroxyvitamin D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians

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Vaidya, Anand, Forman, John P, Hopkins, Paul N, Seely, Ellen W, Williams, Jonathan S·2011·Journal of the Renin-Angiotensin-Aldosterone System

DOI 10.1177/1470320310391922PMC PMC3146958

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Abstract

Introduction: Concentrations of 1,25-hydroxyvitamin D have been positively associated with dietary sodium and salt sensitivity (SS) of blood pressure (BP), and inversely with plasma renin activity (PRA). We investigated the association between PRA and 25-hydroxyvitamin D (25OHD), the most clinically relevant vitamin D metabolite, and whether 25OHD associates with SS of BP in renin phenotypes of hypertension. Methods: We performed cross-sectional analyses on 223 Caucasian subjects with hypertension maintained in high and low dietary sodium balance. Subjects were distinguished as having low-renin (LR) or normal-renin (NR) hypertension. Multivariable linear regression was used to evaluate adjusted relationships. Results: Increasing 25OHD concentrations were inversely associated with PRA ( p < 0.05) on both salt diets. Furthermore, 25OHD was associated with SS of BP in LR hypertension (b = 0.62, p = 0.04), but not in NR hypertension (b = 0.06, p = 0.59). In an adjusted multivariable interaction model, renin status (LR vs . NR) was a significant effect modifier of the relationship between 25OHD and SS of BP ( p = 0.04). Conclusions: Our findings suggest that 25OHD is inversely associated with PRA and positively associated with SS of BP in LR hypertension subjects. These results extend and support prior evidence indicating an interaction between dietary sodium, the RAS, and vitamin D that influences BP in hypertension.

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Vitamin D Deficiency
Holick, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra070553 · Cited by 13,720 · see citing works
Vitamin D deficiency: a worldwide problem with health consequences
Holick, M. F., & Chen, T. C. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.1080s · Cited by 2,689 · see citing works
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
Li, Y. C., Kong, J., Wei, M., Chen, Z.-F., Liu, S. Q., & Cao, L.-P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215219 · Cited by 1,625 · see citing works
Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension
Forman, J. P., Giovannucci, E. L., Holmes, M. D., Bischoff-Ferrari, H. A., Tworoger, S. S., Willett, W. C., & Curhan, G. C. (2007) · Hypertension · doi:10.1161/hypertensionaha.107.087288 · Cited by 896 · see citing works
Self-citation
Prevalence of Vitamin D Inadequacy among Postmenopausal North American Women Receiving Osteoporosis Therapy
Holick, M. F., Siris, E. S., Binkley, N., Beard, M. K., Khan, A., Katzer, J. T., Petruschke, R. A., Chen, E., & de Papp, A. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2364 · Cited by 886 · see citing works
Salt Sensitivity of Blood Pressure in Humans
Weinberger, M. H. (1996) · Hypertension · doi:10.1161/01.hyp.27.3.481 · Cited by 857 · see citing works
Definitions and characteristics of sodium sensitivity and blood pressure resistance.
Weinberger, M. H., Miller, J. Z., Luft, F. C., Grim, C. E., & Fineberg, N. S. (1986) · Hypertension · doi:10.1161/01.hyp.8.6_pt_2.ii127 · Cited by 775 · see citing works
Correlation of Platelet Calcium with Blood Pressure
Erné, P., Bolli, P., Bürgisser, E., & Bühler, F. R. (1984) · New England Journal of Medicine · doi:10.1056/nejm198404263101705 · Cited by 532 · see citing works
Subtle Acquired Renal Injury as a Mechanism of Salt-Sensitive Hypertension
Johnson, R. J., Herrera-Acosta, J., Schreiner, G. F., & Rodríguez‐Iturbe, B. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011078 · Cited by 443 · see citing works
Plasma Parathyroid Hormone and the Risk of Cardiovascular Mortality in the Community
Hagström, E., Hellman, P., Larsson, T. E., Ingelsson, E., Berglund, L., Sundström, J., Melhus, H., Held, C., Lind, L., Michaëlsson, K., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.808733 · Cited by 416 · see citing works
Vitamin D status and arterial hypertension: a systematic review
Pilz, S., Tomaschitz, A., Ritz, E., & Pieber, T. R. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.135 · Cited by 397 · see citing works
Journal of Human Hypertension
(2019) · Journal of Human Hypertension · doi:10.1038/41371.1476-5527 · Cited by 389 · see citing works
Calcium-Regulating Hormones in Essential Hypertension
Resnick, L. M., MÜLLER, F. B., & LARAGH, J. H. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-105-5-649 · Cited by 371 · see citing works
Vitamin D regulation of the renin–angiotensin system
Li, Y. C. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10343 · Cited by 357 · see citing works
Plasma 25-Hydroxyvitamin D and Regulation of the Renin-Angiotensin System in Humans
Forman, J. P., Williams, J. S., & Fisher, N. D. L. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.148619 · Cited by 331 · see citing works
Self-citation
Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin–angiotensin system
Tomaschitz, A., Pilz, S., Ritz, E., Grammer, T., Drechsler, C., Boehm, B. O., & März, W. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.05.037 · Cited by 246 · see citing works
Vitamin D Receptor Attenuates Renal Fibrosis by Suppressing the Renin-Angiotensin System
Zhang, Y., Kong, J., Deb, D. K., Chang, A., & Li, Y. C. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009080872 · Cited by 242 · see citing works
Prevalence of Vitamin D Inadequacy Among Postmenopausal North American Women Receiving Osteoporosis Therapy
Holick, M. F., Siris, E. S., Binkley, N., Beard, M. K., Khan, A. A., Katzer, J. T., Petruschke, R. A., Chen, E., & de Papp, A. E. (2005) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000180860.99260.dd · Cited by 239 · see citing works
Salt sensitivity and resistance of blood pressure. Age and race as factors in physiological responses.
Luft, F. C., Miller, J. Z., Grim, C. E., Fineberg, N. S., Christian, J. C., Daugherty, S. A., & Weinberger, M. H. (1991) · Hypertension · doi:10.1161/01.hyp.17.1_suppl.i102 · Cited by 198 · see citing works
Activity Assays and Immunoassays for Plasma Renin and Prorenin: Information Provided and Precautions Necessary for Accurate Measurement
Campbell, D. J., Nussberger, J., Stowasser, M., Danser, A. H. J., Morganti, A., Frandsen, E., & Ménard, J. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.118000 · Cited by 187 · see citing works
Ionic Basis of Hypertension, Insulin Resistance, Vascular Disease, and Related Disorders The Mechanism of “Syndrome X”
Resnick, L. M. (1993) · American Journal of Hypertension · doi:10.1093/ajh/6.4s.123s · Cited by 166 · see citing works
Vitamin D deficiency and myocardial diseases
Pilz, S., Tomaschitz, A., Drechsler, C., Dekker, J. M., & März, W. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900474 · Cited by 164 · see citing works
Chronic continuous PTH infusion results in hypertension in normal subjects.
Hulter, H. N., Melby, J. C., Peterson, J. C., & Cooke, C. R. (1986) · PubMed · Cited by 161 · see citing works
Parathyroid hormone level is associated with mortality and cardiovascular events in patients undergoing coronary angiography
Pilz, S., Tomaschitz, A., Drechsler, C., Ritz, E., Boehm, B. O., Grammer, T. B., & Marz, W. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq109 · Cited by 160 · see citing works
Vitamin D and Hypertension
Vaidya, A., & Forman, J. P. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.140160 · Cited by 147 · see citing works
Self-citation
Interaction of 1,25-Dihydroxyvitamin D and Plasma Renin Activity in High Renin Essential Hypertension
Burgess, E. D., Hawkins, R. G., & Watanabe, M. (1990) · American Journal of Hypertension · doi:10.1093/ajh/3.12.903 · Cited by 134 · see citing works
Targeted vitamin D receptor expression in juxtaglomerular cells suppresses renin expression independent of parathyroid hormone and calcium
Kong, J., Qiao, G., Zhang, Z., Liu, S. Q., & Li, Y. C. (2008) · Kidney International · doi:10.1038/ki.2008.452 · Cited by 122 · see citing works
Possible renoprotection by vitamin D in chronic renal disease: beyond mineral metabolism
Doorenbos, C. R. C., van den Born, J., Navis, G. J., & de Borst, M. H. (2009) · Nature Reviews Nephrology · doi:10.1038/nrneph.2009.185 · Cited by 113 · see citing works
The role of calcium in the regulation of renin secretion
Beierwaltes, W. H. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00143.2009 · Cited by 110 · see citing works
Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT 1 receptor antagonist
Zhang, Y., Deb, D. K., Kong, J., Ning, G., Wang, Y., Li, G. Q., Chen, Y., Zhang, Z., Strugnell, S. A., Sabbagh, Y., et al. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00247.2009 · Cited by 95 · see citing works
Reduction of Blood Pressure During Long-term Treatment With Active Vitamin D (Alphacalcidol) Is Dependent on Plasma Renin Activity and Calcium Status
Lind, L., Wengle, B., WIDE, L. E., & Ljunghall, S. (1989) · American Journal of Hypertension · doi:10.1093/ajh/2.1.20 · Cited by 90 · see citing works
Hypertension and primary hyperparathyroidism: the role of adrenergic and renin-angiotensin-aldosterone systems.
Gennari, C., Nami, R., & Gonnelli, S. (1995) · PubMed · Cited by 86 · see citing works
Independent associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with blood pressure among US adults
Zhao, G., Ford, E. S., Li, C., Kris‐Etherton, P. M., Etherton, T. D., & Balluz, L. S. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e32833bc5b4 · Cited by 84 · see citing works
Interrelationships between the renin-angiotensin-aldosterone and calcium homeostatic systems
Grant, F. D., Mandel, S. J., Brown, E. M., Williams, G. H., & Seely, E. W. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.4.1400892 · Cited by 76 · see citing works
Self-citation
Calcium metabolism in essential hypertension: relationship to altered renin system activity.
Resnick, L. M., Nicholson, J., & Laragh, J. H. (1986) · PubMed · Cited by 71 · see citing works
Autonomy of the renin system in type II diabetes mellitus: Dietary sodium and renal hemodynamic responses to ACE inhibition
DE'OLIVEIRA, J. M. F., Price, D. A., Fisher, N. D. L., Allan, D. R., McKnight, J. A., Williams, G. H., & Hollenberg, N. K. (1997) · Kidney International · doi:10.1038/ki.1997.394 · Cited by 68 · see citing works
Uniformity and diversity of calcium metabolism in hypertension: A conceptual framework
Resnick, L. M. (1987) · The American Journal of Medicine · doi:10.1016/0002-9343(87)90267-1 · Cited by 68 · see citing works
Altered Adrenal Sensitivity to Angiotensin II in Low-Renin Essential Hypertension
Fisher, N. D. L., Hurwitz, S., Ferri, C., Jeunemaı̂tre, X., Hollenberg, N. K., & Williams, G. H. (1999) · Hypertension · doi:10.1161/01.hyp.34.3.388 · Cited by 68 · see citing works
Renal Perfusion in Blacks
Price, D. A., Fisher, N. D. L., Lansang, M. C., Stevanovic, R. D., Williams, G. H., & Hollenberg, N. K. (2002) · Hypertension · doi:10.1161/01.hyp.0000024349.85680.87 · Cited by 65 · see citing works
Insulin resistance in hypertensives: effect of salt sensitivity, renin status and sodium intake
Raji, A., Williams, G. H., Jeunemaı̂tre, X., Hopkins, P. N., Hunt, S. C., Hollenberg, N. K., & Seely, E. W. (2001) · Journal of Hypertension · doi:10.1097/00004872-200101000-00013 · Cited by 64 · see citing works
Self-citation
The state and responsiveness of the renin-angiotensin-aldosterone system in patients with type II diabetes mellitus
PRICE, D., DEOLIVEIRA, J., Fisher, N. D. L., WILLIAMS, G., & Hollenberg, N. K. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(00)86960-5 · Cited by 64 · see citing works
1,25-Dihydroxyvitamin D as a Cardiovascular Hormone Effects on Calcium Current and Cytosolic Free Calcium in Vascular Smooth Muscle Cells
Shan, J. J., Resnick, L. M., Lewanczuk, R. Z., Karpinski, E., Li, B., & Pang, P. K. T. (1993) · American Journal of Hypertension · doi:10.1093/ajh/6.12.983 · Cited by 54 · see citing works
Vitamin D and the vascular sensitivity to angiotensin II in obese Caucasians with hypertension
Vaidya, A., Forman, J. P., & Williams, J. S. (2011) · Journal of Human Hypertension · doi:10.1038/jhh.2010.110 · Cited by 52 · see citing works
Self-citation
A Gender Difference in the Association Between Salt Sensitivity and Family History of Hypertension
Shunichi, K., Kazuo, M., Genjiro, K., Toru, S., Kaoru, Y., Masahito, I., Hitoshi, A., Minoru, K., Yuhei, K., Ashida, T., et al. (1992) · American Journal of Hypertension · doi:10.1093/ajh/5.1.1 · Cited by 52 · see citing works
The role of calcium in the control of renin release.
Naftilan, A. J., & Oparil, S. (1982) · Hypertension · doi:10.1161/01.hyp.4.5.670 · Cited by 48 · see citing works
Aldosterone to Renin Ratio – A Reliable Screening Tool for Primary Aldosteronism?
Tomaschitz, A., & Pilz, S. (2010) · Hormone and Metabolic Research · doi:10.1055/s-0030-1248326 · Cited by 47 · see citing works
Regulation of aldosterone secretion in hypertensive blacks.
Fisher, N. D. L., Gleason, R. E., Moore, T. J., Williams, G. H., & Hollenberg, N. K. (1994) · Hypertension · doi:10.1161/01.hyp.23.2.179 · Cited by 45 · see citing works
CALCIUM METABOLISM IN ELDERLY HYPERTENSIVE PATIENTS: POSSIBLE PARTICIPATION OF EXAGGERATED SODIUM, CALCIUM AND PHOSPHATE EXCRETION
Imaoka, M., Morimoto, S., Kitano, S., Fukuo, F., & Ogihara, T. (1991) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1991.tb01637.x · Cited by 42 · see citing works
The renin-angiotensin system in blacks: Active, passive, or what?
Price, D. A., & Fisher, N. D. L. (2003) · Current Hypertension Reports · doi:10.1007/s11906-003-0025-x · Cited by 41 · see citing works
Insulin Induces Renal Vasodilation, Increases Plasma Renin Activity, and Sensitizes the Renal Vasculature to Angiotensin Receptor Blockade in Healthy Subjects
Perlstein, T. S., Gerhard-Herman, M., Hollenberg, N. K., Williams, G. H., & Thomas, A. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006091026 · Cited by 39 · cited 2× · see citing works
“The generalizability of our findings is limited to the population we analyzed, a relatively homogenous group of hypertensive Caucasians without diabetes; this demographic restriction allowed for more reliable results since race [29–31] and diabetes [27, 32–34] are potential confounders of the RAS.”
BackgroundResult
Effects of age and sex on sodium chloride sensitivity: association with plasma renin activity.
Ishibashi, K., Oshima, T., Matsuura, H., WATANABE, M., Ishida, M., Ishida, T., Ozono, R., Kajiyama, G., & KANBE, M. (1994) · PubMed · Cited by 32 · see citing works
Intravenous Delivery of PTH/PTHrP Type 1 Receptor cDNA to Rats Decreases Heart Rate, Blood Pressure, Renal Tone, Renin Angiotensin System, and Stress-Induced Cardiovascular Responses
Fritsch, S., Lindner, V., Welsch, S., Massfelder, T., Grima, M., Rothhut, S., Barthelmebs, M., & Helwig, J. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000141040.77536.af · Cited by 31 · see citing works
Calciotropic Hormones in Human and Experimental Hypertension
Resnick, L. M. (1990) · American Journal of Hypertension · doi:10.1093/ajh/3.8.171 · Cited by 25 · see citing works
Clinical biochemical and haemodynamic correlates of sodium sensitivity in essential hypertension.
Koolen, M. I., den Boer, E. B.-V., & van Brummelen, P. (1983) · PubMed · Cited by 25 · see citing works
Regulation of parathyroid hormone and vitamin D in essential hypertension*
Young, E. W., Morris, C. D., Holcomb, S., McMillan, G., & McCarron, D. A. (1995) · American Journal of Hypertension · doi:10.1016/0895-7061(95)00214-6 · Cited by 23 · see citing works
Influence of dietary sodium on the renin–angiotensin–aldosterone system and prevalence of left ventricular hypertrophy by EKG criteria
Williams, J. S., Williams, G. H., Jeunemaı̂tre, X., Hopkins, P. N., & Conlin, P. R. (2004) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001784 · Cited by 19 · see citing works
Self-citation
Calciotropic hormones in salt-sensitive essential hypertension: 1,25-dihydroxyvitamin D and parathyroid hypertensive factor.
Lm, R. (1994) · PubMed · Cited by 17 · see citing works
Racial differences in renal vascular response to angiotensin blockade with captopril or candesartan
Forman, J. P., Price, D. A., Stevanovic, R. D., & Fisher, N. D. L. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e32803cae1a · Cited by 9 · see citing works
Self-citation
Calcium, Parathyroid Hormone, and Vitamin D in the "Prehypertensive" Dahl Salt-Sensitive Rat
Kotchen, T. A., Oit, C. E., Whitescarver, S. A., Resnick, L. M., Gertner, J. M., & Blehschmidt, N. G. (1990) · American Journal of Hypertension · doi:10.1093/ajh/3.8.167 · Cited by 8 · see citing works
The Antihypertensive Effects of Calcium Channel Blockade
Resnick, L. M., Nicholson, J., & LARAGH, J. H. (1988) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-198812006-00028 · Cited by 7 · see citing works
The Pressor Effect of Sodium-Volume Expansion Is Calcium Mediated
Nicholson, J., Resnick, L. M., Cigarroa, J. E., Marion, D. N., Vaughan, E. D., & Laragh, J. H. (1991) · American Journal of Hypertension · doi:10.1093/ajh/4.11.904 · Cited by 5 · see citing works

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[22]Vaidya A Forman JP Fisher ND Williams JS Vitamin D Deficiency Blunts Vascular Sensitivity to Angiotensin II in Obesity The Journal of Clinical Hypertension 2010 12 Supplement 1 A1 A165

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Panizo, S., Martínez‐Arias, L., Alonso‐Montes, C., Cannata, P., Martín-Carro, B., Martín, J. L. F., Naves‐Díaz, M., Carrillo‐López, N., & Cannata-Andía, J. B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010408 · Cited by 375 · see citing works
Effect of Vitamin D Supplementation on Blood Pressure in Blacks
Forman, J. P., Scott, J. B., Ng, K., Drake, B. F., Suarez, E. G., Hayden, D. L., Bennett, G. G., Chandler, P. D., Hollis, B. W., Emmons, K. M., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00659 · Cited by 218 · see citing works
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Motiwala, S. R., & Wang, T. J. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0262-y · Cited by 61 · see citing works
The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians: Vitamin D receptor polymorphisms and plasma renin activity
Vaidya, A., Sun, B., Forman, J. P., Hopkins, P. N., Brown, N. J., Kolatkar, N. S., Williams, G. H., & Williams, J. S. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.03991.x · Cited by 58 · see citing works
Self-citation
Interaction of Vitamin D with Peptide Hormones with Emphasis on Parathyroid Hormone, FGF23, and the Renin-Angiotensin-Aldosterone System
Latic, N., & Erben, R. G. (2022) · Nutrients · doi:10.3390/nu14235186 · Cited by 61 · see citing works
Vitamin D Depletion Aggravates Hypertension and Target‐Organ Damage
Andersen, L. B., Przybył, Ł., Haase, N., von Versen‐Höynck, F., Qadri, F., Jørgensen, J. S., Sørensen, G. L., Fruekilde, P. B. N., Poglitsch, M., Szijártó, I. A., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.114.001417 · Cited by 56 · see citing works
Cholecalciferol administration blunts the systemic renin–angiotensin system in essential hypertensives with hypovitaminosis D
Carrara, D., Bernini, M., Bacca, A., Rugani, I., Duranti, E., Virdis, A., Ghiadoni, L., Taddei, S., & Bernini, G. P. (2013) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320312471149 · Cited by 56 · see citing works
Vitamin D and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms
Marquina, C., Mousa, A., Scragg, R. K. R., & de Courten, B. V. (2018) · Obesity Reviews · doi:10.1111/obr.12793 · Cited by 56 · see citing works
The influence of body mass index and renin–angiotensin–aldosterone system activity on the relationship between 25-hydroxyvitamin D and adiponectin in Caucasian men
Vaidya, A., Forman, J. P., UNDERWOOD, P. C., Hopkins, P. N., Williams, G. H., Pojoga, L. H., & Williams, J. S. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0025 · Cited by 54 · see citing works
Self-citation
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Trehan, N., Afonso, L., Levine, D. L., & Levy, P. D. (2017) · Critical Pathways in Cardiology A Journal of Evidence-Based Medicine · doi:10.1097/hpc.0000000000000122 · Cited by 50 · see citing works
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Martínez‐Arias, L., Panizo, S., Alonso‐Montes, C., Martín-Vírgala, J., Martín-Carro, B., Fernández-Villabrille, S., Gil-Albert, C. G., Antequera, C. P., Martín, J. L. F., Ruiz‐Torres, M. P., et al. (2020) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaa373 · Cited by 47 · see citing works
The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?
Taha, R., Abureesh, S., Alghamdi, S., Hassan, R., Cheikh, M., Bagabir, R. A., Almoallim, H. M., & Abdulkhaliq, A. A. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s317421 · Cited by 49 · see citing works
Cardiometabolic Risk Factors and Benign Gynecologic Disorders
AlAshqar, A., Patzkowsky, K. E., Afrin, S., Wild, R. A., Taylor, H. S., & Borahay, M. A. (2019) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000718 · Cited by 41 · see citing works
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Vaidya, A., & Forman, J. P. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0248-9 · Cited by 41 · see citing works
Self-citation
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Brown, J. M., & Vaidya, A. (2014) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0000000000000062 · Cited by 39 · see citing works
Self-citation
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Maia, J. M. L., da Silva, A. S., do Carmo, R. F., de Mendonça, T. F., Griz, L., de Moura, P. M. M. F., & Bandeira, F. A. F. (2016) · The Application of Clinical Genetics · doi:10.2147/tacg.s101410 · Cited by 36 · see citing works
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Carrara, D., Bruno, R. M., Bacca, A., Taddei, S., Duranti, E., Ghiadoni, L., & Bernini, G. P. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001072 · Cited by 36 · see citing works
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Gouni‐Berthold, I., & Berthold, H. K. (2020) · Current Vascular Pharmacology · doi:10.2174/1570161118666200317151955 · Cited by 30 · see citing works
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Miao, J., Bachmann, K. N., Huang, S., Su, Y. R., Dusek, J. A., Newton‐Cheh, C., Arora, P. K., & Wang, T. J. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.017727 · Cited by 29 · see citing works
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Nunes, I. F. D. O. C., Cavalcante, A. A. D. C. M., de Alencar, M. V. O. B., de Carvalho, M. D. F., Sarmento, J. L. R., Teixeira, N. D. S. C. C. D. A., Paiva, A. D. A., de Carvalho, L. R., do Nascimento, L. F. M., Cruz, M. S. P., et al. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa076 · Cited by 28 · see citing works
Association between Vitamin D Deficiency and Levels of Renin and Angiotensin in Essential Hypertension
Han, L., Xin-juan, X., Zhang, J., & Liu, H. M. (2022) · International Journal of Clinical Practice · doi:10.1155/2022/8975396 · Cited by 27 · see citing works
Effects of aerobic exercise on adiponectin levels potentially mediated by vitamin D in type 2 diabetic patients
Mudjanarko, S. W., Irawati, A., & Tinduh, D. (2022) · Endocrine Regulations · doi:10.2478/enr-2022-0021 · Cited by 26 · see citing works
Associations between Vitamin D and Cardiovascular Disease Risk Factors in African Americans Are Partly Explained by Circulating Adipokines and C-Reactive Protein: The Jackson Heart Study
Khan, R., Gebreab, S. Y., Riestra, P., Sims, M., Gaye, A., Xu, R., & Davis, S. (2016) · Journal of Nutrition · doi:10.3945/jn.116.239509 · Cited by 25 · see citing works
Association between Vitamin D and Adiponectin and Its Relationship with Body Mass Index: The META-Health Study
Bidulescu, A., Morris, A. A., Stoyanova, N., Meng, Y., Vaccarino, V., Quyyumi, A. A., & Gibbons, G. H. (2014) · Frontiers in Public Health · doi:10.3389/fpubh.2014.00193 · Cited by 25 · see citing works
Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link
Awasthi, R., Manger, P. T., & Khare, R. K. (2023) · Clinical Hypertension · doi:10.1186/s40885-022-00229-y · Cited by 24 · see citing works
Effect of acute and chronic vitamin D administration on systemic renin angiotensin system in essential hypertensives and controls
BERNINI, G. P., Carrara, D., Bacca, A., Carli, V., Virdis, A., Rugani, I., Duranti, E., Ghiadoni, L., Bernini, M., & Taddei, S. (2013) · Journal of Endocrinological Investigation · doi:10.1007/bf03347275 · Cited by 24 · see citing works
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Vaidya, A., Pojoga, L. H., UNDERWOOD, P. C., Forman, J. P., Hopkins, P. N., Williams, G. H., & Williams, J. S. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03922.x · Cited by 23 · see citing works
Self-citation
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Gironés‐Vilaplana, A., Villaño, D., Marhuenda, J., Moreno, D. A., & García‐Viguera, C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805257-0.00006-5 · Cited by 23 · see citing works
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Li, Y. C. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381978-9.10040-x · Cited by 21 · see citing works
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Brown, J. M., Secinaro, K., Williams, J. S., & Vaidya, A. (2013) · BMC Endocrine Disorders · doi:10.1186/1472-6823-13-33 · Cited by 20 · see citing works
Self-citation
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Modica, R., Liccardi, A., Minotta, R., Benevento, E., Cannavale, G., & Colao, A. A. L. (2023) · Journal of Endocrinological Investigation · doi:10.1007/s40618-023-02018-2 · Cited by 18 · see citing works
Bone and mineral metabolism in patients with primary aldosteronism: A systematic review and meta-analysis
Wang, A., Wang, Y., Liu, H., Hu, X., Li, J., Xu, H., Nie, Z., Zhang, L., & Lyu, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1027841 · Cited by 19 · see citing works
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Vaidya, A. (2013) · Metabolism · doi:10.1016/j.metabol.2013.08.009 · Cited by 18 · see citing works
Self-citation
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Karohl, C., Vaccarino, V., Veledar, E., Goldberg, J. H., Tangpricha, V., Bellasi, A., & Raggi, P. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3097 · Cited by 17 · see citing works
Vitamin D Receptor Deficiency Does Not Affect Blood Pressure and Heart Function
Grundmann, S. M., Schutkowski, A., Schreier, B., Rabe, S., König, B., Gekle, M., & Stangl, G. I. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01118 · Cited by 16 · see citing works
Therapeutic Vitamin D Supplementation Following COVID-19 Diagnosis: Where Do We Stand?—A Systematic Review
Bania, A., Pitsikakis, K., Mavrovounis, G., Mermiri, M., Beltsios, E. T., Adamou, A., Konstantaki, V., Makris, D. A., Tsolaki, V., Gourgoulianis, K. I., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12030419 · Cited by 15 · see citing works
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Zaheer, S., Taquechel, K., Brown, J. M., Adler, G. K., Williams, J. S., & Vaidya, A. (2018) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320317754178 · Cited by 14 · see citing works
Self-citation
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Wahba, N. S., Ghareib, S. A., Abdel-Ghany, R. H., Abdel-Aal, M., & Alsemeh, A. E. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02249-6 · Cited by 14 · see citing works
Retracted
Vitamin D status and calcium intake in systemic inflammation, insulin resistance and the metabolic syndrome: An update on current evidence
Soares, M. J., Pannu, P. K., Calton, E. K., Reid, C. M., & Hills, A. P. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.01.009 · Cited by 14 · see citing works
Vitamin D deficiency enhances vascular oxidative stress, inflammation, and angiotensin II levels in the microcirculation of diabetic patients
Wee, C. L., Azemi, A. K., Mokhtar, S. S., Yahaya, S., Yaacob, N. S., & Rasool, A. H. G. (2023) · Microvascular Research · doi:10.1016/j.mvr.2023.104574 · Cited by 13 · see citing works
Is the renin–angiotensin system actually hypertensive?
Bérard, E., Niel, O., & Rubio, A. (2013) · Pediatric Nephrology · doi:10.1007/s00467-013-2481-0 · Cited by 12 · see citing works
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Vaidya, A., UNDERWOOD, P. C., Annes, J. P., Sun, B., Williams, G. H., Forman, J. P., & Williams, J. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.10.001 · Cited by 11 · see citing works
Self-citation
IgA nephropathy with early kidney disease is associated with increased arterial stiffness and renin–angiotensin system activity
Abdi-Ali, A., Mann, M. C., Hemmelgarn, B. R., MacRae, J. M., Turin, T. C., Benediktsson, H., Sola, D., & Ahmed, S. (2014) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320313510586 · Cited by 12 · see citing works
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Rosas-Peralta, M., Holick, M. F., Borrayo–Sánchez, G., Madrid-Miller, A., Ramírez-Árias, E., & Arizmendi-Uribe, E. (2017) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2016.11.009 · Cited by 12 · see citing works
Cardiovascular benefits of vitamin D.
Dong, J., Lau, C. W., Wong, S. L., & Huang, Y. (2014) · PubMed · Cited by 11 · see citing works
Risk of Myocardial Infarction Among New Users of Calcium Supplements Alone or Combined With Vitamin D: A Population‐Based Case‐Control Study
Rodríguez‐Martín, S., González‐Bermejo, D., Rodríguez, A., Barreira, D., García‐Lledó, A., Gil, M., & de Abajo, F. J. (2019) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1636 · Cited by 11 · see citing works
The effect of cholecalciferol supplementation on allograft function in incident kidney transplant recipients: A randomized controlled study
Doi, Y., Tsujita, M., Hamano, T., Obi, Y., Namba‐Hamano, T., Tomosugi, T., Futamura, K., Okada, M., Hiramitsu, T., Goto, N., et al. (2021) · American Journal of Transplantation · doi:10.1111/ajt.16530 · Cited by 11 · see citing works
Top Three Pharmacogenomics and Personalized Medicine Applications at the Nexus of Renal Pathophysiology and Cardiovascular Medicine
Bochud, M., Burnier, M., & Guessous, I. (2011) · Current pharmacogenomics and personalized medicine (Online)/Current pharmacogenomics and personalized medicine · doi:10.2174/187569211798377135 · Cited by 10 · see citing works
Vitamin D receptor activator and dietary sodium restriction to reduce residual urinary albumin excretion in chronic kidney disease (ViRTUE study): rationale and study protocol
Velde‐Keyzer, C. A. T., de Jong, M. A., van Breda, G. F., Vervloet, M. G., Laverman, G. D., Hemmelder, M. H., Janssen, W. M. T., Heerspink, H. J. L., Navis, G. J., & de Borst, M. H. (2015) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv033 · Cited by 10 · see citing works
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Abdi-Ali, A., Nicholl, D. D. M., Hemmelgarn, B. R., MacRae, J. M., Sola, D. Y., & Ahmed, S. B. (2013) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2013.827705 · Cited by 10 · see citing works
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Wu, W., Qiao, A., & Du, T. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177783 · Cited by 8 · see citing works
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Li, Y. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809965-0.00045-8 · Cited by 8 · see citing works
The unique response of renin and aldosterone to dietary sodium intervention in sodium sensitivity
Shin, S. J., Lim, C., Oh, S. W., & Rhee, M. (2014) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320314526437 · Cited by 8 · see citing works
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Ciebiera, M., Włodarczyk, M., Słabuszewska-Jóźwiak, A., Ciebiera, M., Nowicka, G., & Jakiel, G. (2017) · Archives of Medical Science · doi:10.5114/aoms.2017.70887 · Cited by 8 · see citing works
Low Response of Renin–Angiotensin System to Sodium Intake Intervention in Chinese Hypertensive Patients
Feng, W., Cai, Q., Yuan, W., Liu, Y., Bardeesi, A. S. A., Wang, J., Chen, J., & Huang, H. (2016) · Medicine · doi:10.1097/md.0000000000002602 · Cited by 7 · see citing works
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Li, Y. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91386-7.00015-5 · Cited by 7 · see citing works
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Ristić, S. (2017) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2017.40 · Cited by 7 · see citing works
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Loh, H. H., Azizan, E. A., & Sukor, N. (2025) · Journal of Hypertension · doi:10.1097/hjh.0000000000004046 · Cited by 6 · see citing works
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Chiang, W., Hsiao, P.-J., & Chan, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.930176 · Cited by 6 · see citing works
Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable? An evidence based unraveling
Basha, S. L., Suresh, S., Reddy, A., & Teja, S. P. S. (2020) · Clinical Epidemiology and Global Health · doi:10.1016/j.cegh.2020.10.005 · Cited by 4 · see citing works
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Gohil, P. V., & Solanki, P. (2014) · International Journal of Pharmacological Research · doi:10.7439/ijpr.v4i2.84 · Cited by 4 · see citing works
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Katičić, D., Josipović, J., & Pavlović, D. (2014) · Cardiologia Croatica · doi:10.15836/ccar.2014.263 · Cited by 3 · see citing works
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Naik, V. (2019) · Journal of Endocrinology and Thyroid Research · doi:10.19080/jetr.2019.04.555637 · Cited by 3 · see citing works
Effect of calcifediol supplementation on renin-angiotensin-aldosterone system mediators in dogs with chronic kidney disease
Miller, M., Quimby, J. M., Langston, C., Ames, M. K., & Parker, V. J. (2022) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.16499 · Cited by 3 · see citing works
Should We Be Recommending Vitamin D Supplementation for Hypertension and Cardiovascular Disease Prevention?
Cohen, D. L., & Townsend, R. R. (2012) · Journal of Clinical Hypertension · doi:10.1111/jch.12010 · Cited by 2 · see citing works
The role of calcium and vitamin D in arterial hypertension
Tuyzarova, I., Свеклина, Т. С., Козлов, В. А., & Sardinov, R. T. (2020) · Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» · doi:10.25557/0031-2991.2020.02.117-123 · Cited by 2 · see citing works
Vitamins
Benzal, J. D. G., Aiello, P., Moreno, D. A., García‐Viguera, C., & Villaño, D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85052-0.00004-0 · Cited by 2 · see citing works
Prevalence, clinical characteristics and management of low-renin hypertension: a real-world cohort study
Shah, S. S., Ng, C., Chow, M. W., Fuller, P. J., Young, M. J., Libianto, R., & Yang, J. (2026) · Journal of Human Hypertension · doi:10.1038/s41371-026-01148-3 · Cited by 1 · see citing works
The relationship between vitamin D levels and plasma renin activity in patients with arterial hypertension
Yankovskaya, L., Snezhitskiy, V. А., & Novogran, V. I. (2017) · Clinical Medicine (Russian Journal) · doi:10.18821/0023-2149-2017-95-9-803-809 · Cited by 1 · see citing works
The Effect of Vitamin D on Blood Pressure at Rest and in Response to a Peak Graded Exercise Test
Armstrong, B. (2016) · OpenCommons - UConn (University of Connecticut)
Estimation of serum Vitamin D level in hypertension and hypertension related complications
Sundareshwaran, M., Narayanan, S. K., & Rao, M. R. (2022) · International Journal of Advanced Research in Medicine · doi:10.22271/27069567.2022.v4.i1a.312
Vitamin D Deficiency in Critically Ill Children in Karachi
Abro, F., Baloch, F., Hussain, M., Noreen, A., Noor, N., Arshad, U., & Rafique, B. (2022) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs22163567
High-salt diets provoke phosphorus absorption from the small intestine in mice
Yang, M., You, H., Li, N., Mao, J., & Chen, J. (2025) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2025.2472066

Interaction of 1,25-Dihydroxyvitamin D and Plasma Renin Activity in High Renin Essential Hypertension
Burgess, E. D., Hawkins, R. G., & Watanabe, M. (1990) · American Journal of Hypertension · doi:10.1093/ajh/3.12.903 · Cited by 134 · see citing works
The association of plasma resistin with dietary sodium manipulation, the renin-angiotensin-aldosterone system, and 25-Hydroxyvitamin D3 in human hypertension
Vaidya, A., Pojoga, L. H., UNDERWOOD, P. C., Forman, J. P., Hopkins, P. N., Williams, G. H., & Williams, J. S. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03922.x · Cited by 23 · see citing works
Self-citation
Plasma 25-hydroxyvitamin D concentrations are inversely associated with blood pressure of Dahl salt-sensitive rats
Thierry-Palmer, M., Carlyle, K. S., Williams, M. D., Tewolde, T. K., Caines-McKenzie, S., Bayorh, M. A., Emmett, N. L., Harris‐Hooker, S., Sanford, G. L., & Williams, E. F. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00037-5 · Cited by 28 · see citing works
The relationship between vitamin D levels and plasma renin activity in patients with arterial hypertension
Yankovskaya, L., Snezhitskiy, V. А., & Novogran, V. I. (2017) · Clinical Medicine (Russian Journal) · doi:10.18821/0023-2149-2017-95-9-803-809 · Cited by 1 · see citing works
Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin–angiotensin system
Tomaschitz, A., Pilz, S., Ritz, E., Grammer, T., Drechsler, C., Boehm, B. O., & März, W. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.05.037 · Cited by 246 · see citing works

Authors: Vaidya, A., Forman, J. P., Hopkins, P. N., Seely, E. W., & Williams, J. S.
Affiliations: Brigham and Women's Hospital (US)
University of Utah (US)
ORCID: Vaidya, Anand
Hopkins, Paul N
Seely, Ellen W
Williams, Jonathan S
Venue: Journal of the Renin-Angiotensin-Aldosterone System
Publisher: SAGE Publications
Published: 2011-02-17
Volume: 12
Issue: 3
Pages: 311-319
ISSN: 1470-3203 (ISSN-L)
1752-8976
DOI: 10.1177/1470320310391922
PMC: PMC3146958
OpenAlex: W2154657471
Cited by: 93
References: 63
Citations by year: 2026: 1 · 2025: 3 · 2023: 5 · 2022: 9 · 2021: 6 · 2020: 7 · 2019: 5 · 2018: 2 · 2017: 10 · 2016: 7 · 2015: 3 · 2014: 8 · 2013: 11 · 2012: 9
FWCI: 7.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of the Renin-Angiotensin-Aldosterone System (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: University of Utah
National Institutes of Health (1k23hl004236-01)
National Heart, Lung, and Blood Institute (K23HL084236, F32HL104776, K24HL096141, Z01HL004236, K23 HL04236-03, K08HL079929)
National Center for Research Resources (UL1RR025758, M01RR002635)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
Keywords: 25-hydroxyvitamin D, vitamin D, plasma renin activity, salt sensitivity of blood pressure, hypertension, low-renin hypertension, renin-angiotensin system, dietary sodium, effect modification
MeSH terms: Cross-Sectional Studies, Female, Humans, Hypertension, Male, Middle Aged, Renin, Sodium, Dietary, Vitamin D, Multivariate Analysis, White People

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25-Hydroxyvitamin D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians

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